NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6981140|ref|NP_036726|]
View 

alpha-lactalbumin precursor [Rattus norvegicus]

Protein Classification

lysozyme family protein; bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 11081454)

lysozyme family protein| bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-137 6.21e-70

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


:

Pssm-ID: 395016  Cd Length: 123  Bit Score: 206.89  E-value: 6.21e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140     20 TEFTKCEVSHAIE--DMDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCD 97
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6981140     98 KFLDDELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQW 137
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQW 120
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-137 6.21e-70

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 206.89  E-value: 6.21e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140     20 TEFTKCEVSHAIE--DMDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCD 97
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6981140     98 KFLDDELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQW 137
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQW 120
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 20-139 8.74e-69

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 203.82  E-value: 8.74e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140   20 TEFTKCEVSHAIED--MDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCD 97
Cdd:cd16898   1 IIFTKCELSQILKEhgLDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6981140   98 KFLDDELADDIVCAKKIVAI-KGIDYWKAHKPMCSEKLEQWRC 139
Cdd:cd16898  81 KLLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-140 5.80e-66

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 197.13  E-value: 5.80e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140      20 TEFTKCEVSHAIED--MDGYQGISLLEWTCVLFHTSGYDSQAIVKNNG-STEYGLFQISNRNWCKSSEFPESENICDISC 96
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 6981140      97 DKFLDDELADDIVCAKKIVAIKGIDYWKAHKPMC-SEKLEQWR--CE 140
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-137 6.21e-70

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 206.89  E-value: 6.21e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140     20 TEFTKCEVSHAIE--DMDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCD 97
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6981140     98 KFLDDELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQW 137
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQW 120
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 20-139 8.74e-69

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 203.82  E-value: 8.74e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140   20 TEFTKCEVSHAIED--MDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCD 97
Cdd:cd16898   1 IIFTKCELSQILKEhgLDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6981140   98 KFLDDELADDIVCAKKIVAI-KGIDYWKAHKPMCSEKLEQWRC 139
Cdd:cd16898  81 KLLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-140 5.80e-66

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 197.13  E-value: 5.80e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140      20 TEFTKCEVSHAIED--MDGYQGISLLEWTCVLFHTSGYDSQAIVKNNG-STEYGLFQISNRNWCKSSEFPESENICDISC 96
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 6981140      97 DKFLDDELADDIVCAKKIVAIKGIDYWKAHKPMC-SEKLEQWR--CE 140
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 22-137 5.79e-55

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 168.90  E-value: 5.79e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140   22 FTKCEVSHAIEDMDGYQGISLLEWTCVLFHTSGYDSQAIVKN-NGSTEYGLFQISNRNWCKSSEFPESENICDISCDKFL 100
Cdd:cd00119   3 FTRCELARLLKDIGGYGGISLPNWVCLMKHESGYDTQATNENnNGSTDYGLFQINSRYWCKDGQTPGARNICDISCSKLL 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6981140  101 DDELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQW 137
Cdd:cd00119  83 TDDITDAIMCAKKIVDDKGIDAWVAWKNHCQNKLRQY 119
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 22-137 1.43e-36

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 122.37  E-value: 1.43e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140   22 FTKCEVSHAIED--MDGYQGISLLEWTCVLFHTSGYDSQAIVKNN-GSTEYGLFQISNRNWCKSSEFPeSENICDISCDK 98
Cdd:cd16897   3 FSRCELARILKRggLDGYRGYSLANWVCLAYYESGFNTRATNENPdGSTDYGIFQINSRYWCNDGKTP-SKNLCHISCSD 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6981140   99 FLDDELADDIVCAKKIVA-IKGIDYWKAHKPMCSEK-LEQW 137
Cdd:cd16897  82 LLNDDITDDIKCAKKIVKdPQGMGAWVAWRLHCEGRdLSRW 122
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 22-133 5.28e-28

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 100.38  E-value: 5.28e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981140   22 FTKCEVSHAIEDmdgyQGIS---LLEWTCVLFHTSGYDSQAI--VKNNGSTEYGLFQISNRNWCKSSEfpESENICDISC 96
Cdd:cd16899   3 FTRCELARELRK----LGVPrsqLANWVCLAEHESSFNTTAVggPNSDGSGDYGLFQINDKYWCSPGG--GSGNGCNVKC 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6981140   97 DKFLDDELADDIVCAKKIVAIKGIDYWKAHKPMCSEK 133
Cdd:cd16899  77 EDLLDDDISDDVKCAKKIYKEQGFNAWVGWKNKCKGK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH