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    Ppp6r3 protein phosphatase 6, regulatory subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309144, updated on 9-Dec-2024

    Summary

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    Symbol
    Ppp6r3provided by RGD
    Full Name
    protein phosphatase 6, regulatory subunit 3provided by RGD
    Primary source
    RGD:1307145
    See related
    EnsemblRapid:ENSRNOG00000015540 AllianceGenome:RGD:1307145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Saps3; Saps3-ps1; Ppp6r3-ps1; RGD1307145
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 259.3), Thymus (RPKM 231.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp6r3 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210122394..210236839, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200693128..200807578, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218695738..218810139, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483953 Neighboring gene testis expressed metallothionein like protein Neighboring gene galanin and GMAP prepropeptide Neighboring gene RNA, U6 small nuclear 993 Neighboring gene transfer RNA asparagine (anticodon GUU) 1 Neighboring gene UTP3, small subunit processome component, pseudogene 1 Neighboring gene apolipoprotein A-II like 1 Neighboring gene LDL receptor related protein 5 Neighboring gene 40S ribosomal protein S9 pseudogene Neighboring gene uncharacterized LOC134483954

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of the Rho GTPase-activating protein RICS in neurite outgrowth. Nasu-Nishimura Y, et al. Genes Cells, 2006 Jun. PMID 16716191
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 3
    Names
    SAPS domain family, member 3, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395099.1 → NP_001382028.1  serine/threonine-protein phosphatase 6 regulatory subunit 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYL2
      Related
      ENSRNOP00000020886.8, ENSRNOT00000020886.9
      Conserved Domains (2) summary
      PRK13108
      Location:734 → 866
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210122394..210236839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264253.1 → XP_063120323.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    2. XM_039079308.2 → XP_038935236.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      UniProtKB/TrEMBL
      F1MAH5
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    3. XM_017589247.3 → XP_017444736.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      A6HYL0
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    4. XM_017589246.3 → XP_017444735.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

    5. XM_039079344.2 → XP_038935272.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

      UniProtKB/TrEMBL
      A6HYL1, D3ZBT9
      Conserved Domains (2) summary
      PRK13108
      Location:705 → 837
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    6. XM_039079339.2 → XP_038935267.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

      Related
      ENSRNOP00000062399.4, ENSRNOT00000065950.6
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    7. XM_039079331.2 → XP_038935259.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

      Conserved Domains (2) summary
      PRK13108
      Location:717 → 849
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    8. XM_017589243.3 → XP_017444732.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    9. XM_039079325.2 → XP_038935253.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

      Conserved Domains (2) summary
      PRK13108
      Location:728 → 860
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    10. XM_039079321.2 → XP_038935249.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    11. XM_008760128.3 → XP_008758350.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_008758350.1

      UniProtKB/TrEMBL
      F1MAH5
      Related
      ENSRNOP00000107832.1, ENSRNOT00000129761.1
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    12. XM_008760131.3 → XP_008758353.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

      See identical proteins and their annotated locations for XP_008758353.1

      UniProtKB/TrEMBL
      A6HYL2
      Conserved Domains (2) summary
      PRK13108
      Location:734 → 866
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    13. XM_063264249.1 → XP_063120319.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    14. XM_008760129.3 → XP_008758351.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_008758351.1

      UniProtKB/TrEMBL
      F1MAH5
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    15. XM_063264225.1 → XP_063120295.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      UniProtKB/TrEMBL
      F1MAH5

    16. XM_063264241.1 → XP_063120311.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

      UniProtKB/TrEMBL
      A6HYL2

    17. XM_039079349.2 → XP_038935277.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001287134.1: Suppressed sequence

      Description
      NM_001287134.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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