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    RR22 response regulator 22 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819583, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RR22
    Official Full Name
    response regulator 22
    Primary source
    TAIR:AT3G04280
    Locus tag
    AT3G04280
    See related
    Araport:AT3G04280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARR22; response regulator 22; T6K12.10; T6K12_10
    Summary
    Encodes an atypical subtype of the ARR (Arabidopsis response regulator) protein family. ARR22 is more similar to the receiver domains of hybrid kinases than other response regulators. It acts as a phosphohistidine phosphatase when tested with phospho-AHP5 in vitro suggesting that it might be involved in a two-component phosphorelay. Expression of ARR22 transcripts appears to be localized to the chalaza and to be induced by wounding. Ectopic expression of ARR in other parts of the plant leads to reduced cytokinin-related responses and impaired root, shoot, and flower development. Overexpression of wild-type ARR22 in an arr22 mutant background causes variable defects in plant growth and fertility. But, in the same ar22 background, over-expression of versions of ARR22 that should act as dominant-negative or constitutively active proteins, based on mutations to the conserved Asp residue, do not show any phenotypic abnormalities, raising the possibility that these may not act as canonical response regulators.
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    Genomic context

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    See RR22 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (1129862..1131099, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plastid transcriptionally active 3 Neighboring gene two-component response regulator ARR22-like protein Neighboring gene Li-tolerant lipase 1 Neighboring gene RmlC-like cupins superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ARR22 overexpression can suppress plant Two-Component Regulatory Systems. Wallmeroth N, et al. PLoS One, 2019. PMID 30742656, Free PMC Article
    2. Arabidopsis response regulator 22 inhibits cytokinin-regulated gene transcription in vivo. Wallmeroth N, et al. Protoplasma, 2017 Jan. PMID 26769709
    3. Inducible expression of Arabidopsis response regulator 22 (ARR22), a type-C ARR, in transgenic Arabidopsis enhances drought and freezing tolerance. Kang NY, et al. PLoS One, 2013. PMID 24244460, Free PMC Article
    4. Arabidopsis response regulator, ARR22, ectopic expression of which results in phenotypes similar to the wol cytokinin-receptor mutant. Kiba T, et al. Plant Cell Physiol, 2004 Aug. PMID 15356332
    5. Spatial and temporal expression of the response regulators ARR22 and ARR24 in Arabidopsis thaliana. Gattolin S, et al. J Exp Bot, 2006. PMID 17099079

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARR2 overexpression can inhibit the cytokinins Two component system in transgenic plants.
      Title: ARR22 overexpression can suppress plant Two-Component Regulatory Systems.
    2. ARR22 inhibits gene transcription of an A-type response regulators upon cytokinin treatment in vivo.
      Title: Arabidopsis response regulator 22 inhibits cytokinin-regulated gene transcription in vivo.
    3. ARR22 plays a positive role in the stress tolerance response in part via enhancing cell membrane integrity and that phospho-histidine phosphatase activity of ARR22 may be required for this function.
      Title: Inducible expression of Arabidopsis response regulator 22 (ARR22), a type-C ARR, in transgenic Arabidopsis enhances drought and freezing tolerance.
    4. Results favor the model that ARR22 acts as a phospho-histidine phosphatase on specific AHPs in the cytoplasm of Arabidopsis chalaza cells.
      Title: The Arabidopsis thaliana response regulator ARR22 is a putative AHP phospho-histidine phosphatase expressed in the chalaza of developing seeds.
    5. Spatial and temporal expression of ARR22 is discussed.
      Title: Spatial and temporal expression of the response regulators ARR22 and ARR24 in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084633.1
    NM_111299.3
    NM_180180.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein histidine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    response regulator 22
    NP_001078102.1
    • response regulator 22 (RR22); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789); BEST Arabidopsis thaliana protein match is: response regulator 24 (TAIR:AT5G26594.1); Has 38453 Blast hits to 37735 proteins in 2650 species: Archae - 260; Bacteria - 34151; Metazoa - 17; Fungi - 1133; Plants - 527; Viruses - 9; Other Eukaryotes - 2356 (source: NCBI BLink).
    NP_187078.1
    • response regulator 22 (RR22); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789); BEST Arabidopsis thaliana protein match is: response regulator 24 (TAIR:AT5G26594.1); Has 38320 Blast hits to 37605 proteins in 2640 species: Archae - 260; Bacteria - 34018; Metazoa - 17; Fungi - 1133; Plants - 527; Viruses - 9; Other Eukaryotes - 2356 (source: NCBI BLink).
    NP_850511.1
    • response regulator 22 (RR22); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789); BEST Arabidopsis thaliana protein match is: response regulator 24 (TAIR:AT5G26594.1); Has 38320 Blast hits to 37605 proteins in 2640 species: Archae - 260; Bacteria - 34018; Metazoa - 17; Fungi - 1133; Plants - 527; Viruses - 9; Other Eukaryotes - 2356 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1129862..1131099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111299.3 → NP_187078.1  response regulator 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M8Y4
      UniProtKB/TrEMBL
      A0A178VDZ9, A0A5S9X9C1, A0A654F987
      Conserved Domains (1) summary
      cd17546
      Location:24 → 136
      REC_hyHK_CKI1_RcsC-like; phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC

    2. NM_180180.3 → NP_850511.1  response regulator 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850511.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M8Y4
      UniProtKB/TrEMBL
      A0A178VDZ9, A0A5S9X9C1, A0A654F987
      Conserved Domains (1) summary
      cd17546
      Location:24 → 136
      REC_hyHK_CKI1_RcsC-like; phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC

    3. NM_001084633.1 → NP_001078102.1  response regulator 22 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M8Y4
      UniProtKB/TrEMBL
      A0A178VDZ9, A0A5S9X9C1, A0A654F987
      Conserved Domains (1) summary
      cd17546
      Location:24 → 136
      REC_hyHK_CKI1_RcsC-like; phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8Y4.1

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