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Conserved domains on  [gi|30679083|ref|NP_850511|]
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response regulator 22 [Arabidopsis thaliana]

Protein Classification

response regulator( domain architecture ID 14436104)

response regulator receives the signal from a sensor partner in two-component systems through its receiver (REC) domain

CATH:  3.40.50.2300
Gene Ontology:  GO:0000160|GO:0000156
PubMed:  31100988|20226724
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 24-136 2.23e-33

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


:

Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 113.33  E-value: 2.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREM---KVTSMIVG 100
Cdd:cd17546   1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLK--EEPFDLVLMDLQMPVMDGLEATRRIRELeggGRRTPIIA 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30679083 101 VTSVAdQEEERKAFMEAGLNHCLEKPLTKAKIFPLI 136
Cdd:cd17546  79 LTANA-LEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
 
Name Accession Description Interval E-value
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 24-136 2.23e-33

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 113.33  E-value: 2.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREM---KVTSMIVG 100
Cdd:cd17546   1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLK--EEPFDLVLMDLQMPVMDGLEATRRIRELeggGRRTPIIA 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30679083 101 VTSVAdQEEERKAFMEAGLNHCLEKPLTKAKIFPLI 136
Cdd:cd17546  79 LTANA-LEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 22-142 3.63e-25

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 92.61  E-value: 3.63e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSM--IV 99
Cdd:COG0784   6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGP--PDLILLDINMPGMDGLELLRRIRALPRLPDipII 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30679083 100 GVTSVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLISHLFDA 142
Cdd:COG0784  84 ALTAYADEEDRERA-LEAGADDYLTKPVDPEELLEALRRLLAR 125
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
22-128 6.36e-19

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 81.56  E-value: 6.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:PRK10841 802 MMILVVDDHPINRRLLADQLGSLGYQCKTANDGVDA--LNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGV 879

                         90       100
                 ....*....|....*....|....*..
gi 30679083  102 TSVAdQEEERKAFMEAGLNHCLEKPLT 128
Cdd:PRK10841 880 TANA-LAEEKQRCLEAGMDSCLSKPVT 905
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 24-132 2.91e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.80  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083    24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLK--EERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100
                  ....*....|....*....|....*....
gi 30679083   104 VADqEEERKAFMEAGLNHCLEKPLTKAKI 132
Cdd:pfam00072  79 HGD-EDDAVEALEAGADDFLSKPFDPDEL 106
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 22-78 4.29e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 49.49  E-value: 4.29e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 30679083     22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMP 78
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLK--EEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 24-136 2.23e-33

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 113.33  E-value: 2.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREM---KVTSMIVG 100
Cdd:cd17546   1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLK--EEPFDLVLMDLQMPVMDGLEATRRIRELeggGRRTPIIA 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30679083 101 VTSVAdQEEERKAFMEAGLNHCLEKPLTKAKIFPLI 136
Cdd:cd17546  79 LTANA-LEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 22-142 3.63e-25

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 92.61  E-value: 3.63e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSM--IV 99
Cdd:COG0784   6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGP--PDLILLDINMPGMDGLELLRRIRALPRLPDipII 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30679083 100 GVTSVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLISHLFDA 142
Cdd:COG0784  84 ALTAYADEEDRERA-LEAGADDYLTKPVDPEELLEALRRLLAR 125
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 20-141 2.00e-21

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 83.48  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  20 KLINVLIVDDDPLNRRLHEMIIKTIGGISQ--TAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSM 97
Cdd:COG4565   2 KMIRVLIVEDDPMVAELLRRYLERLPGFEVvgVASSGEEALALLAEHR--PDLILLDIYLPDGDGLELLRELRARGPDVD 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30679083  98 IVGVTSVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLISHLFD 141
Cdd:COG4565  80 VIVITAARDPETVREA-LRAGVVDYLIKPFTFERLREALERYLE 122
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 24-130 3.53e-21

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 83.80  E-value: 3.53e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAV-ILHRDgeaSFDLILMDKEMPERDGVSTTKKLREMKVTSM--IVG 100
Cdd:COG3706   4 ILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALeLLQEH---RPDLILLDLEMPDMDGLELCRRLRADPRTADipIIF 80

                        90       100       110
                ....*....|....*....|....*....|
gi 30679083 101 VTSVADQEEERKAFmEAGLNHCLEKPLTKA 130
Cdd:COG3706  81 LTALDDEEDRARAL-EAGADDYLTKPFDPE 109
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 23-126 6.65e-20

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 78.66  E-value: 6.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQ--TAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVG 100
Cdd:COG4753   1 KVLIVDDEPLIREGLKRILEWEAGFEVvgEAENGEEALELLE--EHKPDLVITDINMPGMDGLELLEAIRELDPDTKIII 78

                        90       100
                ....*....|....*....|....*.
gi 30679083 101 VTSVADQEEERKAfMEAGLNHCLEKP 126
Cdd:COG4753  79 LSGYSDFEYAQEA-IKLGADDYLLKP 103
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 23-141 4.31e-19

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 79.44  E-value: 4.31e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTS--MIVG 100
Cdd:COG3437   8 TVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLL--EAPPDLILLDVRMPGMDGFELLRLLRADPSTRdiPVIF 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 30679083 101 VTSVADQEEERKAFmEAGLNHCLEKPLTKAKIFPLISHLFD 141
Cdd:COG3437  86 LTALADPEDRERAL-EAGADDYLTKPFDPEELLARVRNALE 125
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
22-128 6.36e-19

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 81.56  E-value: 6.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:PRK10841 802 MMILVVDDHPINRRLLADQLGSLGYQCKTANDGVDA--LNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGV 879

                         90       100
                 ....*....|....*....|....*..
gi 30679083  102 TSVAdQEEERKAFMEAGLNHCLEKPLT 128
Cdd:PRK10841 880 TANA-LAEEKQRCLEAGMDSCLSKPVT 905
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 25-126 1.32e-18

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 74.96  E-value: 1.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  25 LIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTSV 104
Cdd:cd00156   1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEA--LELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78

                        90       100
                ....*....|....*....|..
gi 30679083 105 ADQEEERKAfMEAGLNHCLEKP 126
Cdd:cd00156  79 ADEEDAVRA-LELGADDYLVKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 24-132 2.91e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.80  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083    24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLK--EERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100
                  ....*....|....*....|....*....
gi 30679083   104 VADqEEERKAFMEAGLNHCLEKPLTKAKI 132
Cdd:pfam00072  79 HGD-EDDAVEALEAGADDFLSKPFDPDEL 106
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 23-127 1.01e-16

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 70.65  E-value: 1.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMI--VG 100
Cdd:cd17548   1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIAR--KEKPDLILMDIQLPGMDGLEATRLLKEDPATRDIpvIA 78

                        90       100
                ....*....|....*....|....*..
gi 30679083 101 VTSVADQEEERKAfMEAGLNHCLEKPL 127
Cdd:cd17548  79 LTAYAMKGDREKI-LEAGCDGYISKPI 104
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 22-131 1.84e-16

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 69.97  E-value: 1.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGISQ--TAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIV 99
Cdd:cd19925   1 INVLIVEDDPMVAEIHRAYVEQVPGFTVigTAGTGEEA--LKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVI 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 30679083 100 GVTSVADQEEERKAfMEAGLNHCLEKPLTKAK 131
Cdd:cd19925  79 VVTAANDVETVREA-LRLGVVDYLIKPFTFER 109
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 22-138 1.93e-16

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 74.50  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRRL-----HEMIIKTIggisqTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKV-- 94
Cdd:PRK11107 668 LTVMAVDDNPANLKLigallEEQVEHVV-----LCDSGHQAVEQAK--QRPFDLILMDIQMPGMDGIRACELIRQLPHnq 740

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 30679083   95 TSMIVGVTSVAdQEEERKAFMEAGLNHCLEKPLTKAKIFPLISH 138
Cdd:PRK11107 741 NTPIIAVTAHA-MAGERERLLSAGMDDYLAKPIDEAMLKQVLLR 783
PRK15347 PRK15347
two component system sensor kinase;
8-130 9.28e-16

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 72.75  E-value: 9.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083    8 GTEKTKSIEVKKKLINVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTK 87
Cdd:PRK15347 677 PNEPVINLPLQPWQLQILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGR--QHRFDLVLMDIRMPGLDGLETTQ 754

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 30679083   88 KLRE----MKVTSMIVGVTSVAdQEEERKAFMEAGLNHCLEKPLTKA 130
Cdd:PRK15347 755 LWRDdpnnLDPDCMIVALTANA-APEEIHRCKKAGMNHYLTKPVTLA 800
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 23-127 1.70e-15

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 67.47  E-value: 1.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGIS-QTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSM--IV 99
Cdd:cd17551   2 RILIVDDNPTNLLLLEALLRSAGYLEvVSFTDPREALAWCRENP--PDLILLDYMMPGMDGLEFIRRLRALPGLEDvpIV 79

                        90       100
                ....*....|....*....|....*...
gi 30679083 100 GVTSVADQEEERKAFmEAGLNHCLEKPL 127
Cdd:cd17551  80 MITADTDREVRLRAL-EAGATDFLTKPF 106
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 23-141 1.81e-14

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 68.84  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVT 102
Cdd:COG2204   4 RILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEP--PDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 30679083 103 SVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLISHLFD 141
Cdd:COG2204  82 GYGDVETAVEA-IKAGAFDYLTKPFDLEELLAAVERALE 119
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
22-128 1.86e-14

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 68.99  E-value: 1.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083    22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:PRK09959  959 LSILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQA--LHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGL 1036

                          90       100
                  ....*....|....*....|....*..
gi 30679083   102 TSVAdQEEERKAFMEAGLNHCLEKPLT 128
Cdd:PRK09959 1037 TANA-QANEREKGLSCGMNLCLFKPLT 1062
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 24-126 2.23e-14

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 64.40  E-value: 2.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTS--MIVGV 101
Cdd:cd17580   1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEA--LEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLAntPAIAL 78

                        90       100
                ....*....|....*....|....*
gi 30679083 102 TSVAdQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17580  79 TGYG-QPEDRERALEAGFDAHLVKP 102
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 24-126 5.14e-14

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 65.75  E-value: 5.14e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:COG0745   4 ILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLE--EERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTA 81

                        90       100
                ....*....|....*....|...
gi 30679083 104 vADQEEERKAFMEAGLNHCLEKP 126
Cdd:COG0745  82 -RDDEEDRVRGLEAGADDYLTKP 103
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 24-126 1.63e-13

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 62.13  E-value: 1.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMI--VGV 101
Cdd:cd17538   2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAE--EELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIpvIMI 79

                        90       100
                ....*....|....*....|....*
gi 30679083 102 TSVADQEEERKAfMEAGLNHCLEKP 126
Cdd:cd17538  80 TALDDREDRIRG-LEAGADDFLSKP 103
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 22-126 3.58e-13

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 61.64  E-value: 3.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGIS--QTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLreMKVTSM-I 98
Cdd:cd17541   1 IRVLIVDDSAVMRKLLSRILESDPDIEvvGTARDGEEALEKIK--ELKPDVITLDIEMPVMDGLEALRRI--MAERPTpV 76

                        90       100       110
                ....*....|....*....|....*....|
gi 30679083  99 VGVTSVADQEEErKAF--MEAGLNHCLEKP 126
Cdd:cd17541  77 VMVSSLTEEGAE-ITLeaLELGAVDFIAKP 105
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 22-103 6.57e-12

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 60.60  E-value: 6.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGIS--QTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIV 99
Cdd:COG3279   2 MKILIVDDEPLARERLERLLEKYPDLEvvGEASNGEEALELLE--EHKPDLVFLDIQMPGLDGFELARQLRELDPPPPII 79


                ....
gi 30679083 100 GVTS 103
Cdd:COG3279  80 FTTA 83
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 24-126 1.11e-11

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 57.17  E-value: 1.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIvgVTS 103
Cdd:cd17620   1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAA--TRKPDLIILDLGLPDMDGLEVIRRLREWSAVPVI--VLS 76

                        90       100
                ....*....|....*....|...
gi 30679083 104 VADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17620  77 ARDEESDKIAALDAGADDYLTKP 99
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 23-126 1.19e-11

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 57.50  E-value: 1.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAV-ILHrdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:COG5803   4 KILIVDDQAGIRMLLKEVLKKEGYEVFQAANGKEALeKVK---ELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVIMM 80

                        90       100
                ....*....|....*....|....*
gi 30679083 102 TSVADQEEERKAfMEAGLNHCLEKP 126
Cdd:COG5803  81 TAYGELDMVEEA-KELGAKGYFTKP 104
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 24-132 2.93e-11

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 56.64  E-value: 2.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTS---MIVG 100
Cdd:cd19933   3 VLLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLNLLASAEHSFQLVLLDLCMPEMDGFEVALRIRKLFGRRerpLIVA 82

                        90       100       110
                ....*....|....*....|....*....|..
gi 30679083 101 VTSVADqEEERKAFMEAGLNHCLEKPLTKAKI 132
Cdd:cd19933  83 LTANTD-DSTREKCLSLGMNGVITKPVSLHAL 113
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 22-99 3.85e-11

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 56.82  E-value: 3.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGISQ--TAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKL---REMKVTS 96
Cdd:COG2197   2 IRVLIVDDHPLVREGLRALLEAEPDIEVvgEAADGEEALELLE--ELRPDVVLLDIRMPGMDGLEALRRLltpREREVLR 79


                ...
gi 30679083  97 MIV 99
Cdd:COG2197  80 LLA 82
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 24-118 5.93e-11

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 57.73  E-value: 5.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGIS--QTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgV 101
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITvvGEASNGEQGIELAE--SLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIV-V 85

                         90
                 ....*....|....*..
gi 30679083  102 TSVADQEEERKAFMEAG 118
Cdd:PRK10651  86 FSVSNHEEDVVTALKRG 102
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 22-132 6.22e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 55.81  E-value: 6.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIG-GISQTAKNGEEAVILHRDGeaSFDLILMDKEMPERDGVSTTKKLR---EMKVTSM 97
Cdd:cd19923   1 MKVLVVDDFSTMRRIIKNLLKELGfNNVEEAEDGVDALEKLKAG--GFDFVITDWNMPNMDGLELLKTIRadgALSHLPV 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 30679083  98 IVgVTSVADQEEERKAfMEAGLNHCLEKPLT----KAKI 132
Cdd:cd19923  79 LM-VTAEAKKENVIAA-AQAGVNNYIVKPFTaatlKEKL 115
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 25-126 6.83e-11

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 55.11  E-value: 6.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  25 LIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTSV 104
Cdd:cd17574   1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQ--PDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78

                        90       100
                ....*....|....*....|..
gi 30679083 105 aDQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17574  79 -DEEEDKVLGLELGADDYITKP 99
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 24-136 7.54e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 55.50  E-value: 7.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRR-LHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgVT 102
Cdd:cd19932   3 VLIAEDEALIRMdLREMLEEAGYEVVGEASDGEEAVELAK--KHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVL-LT 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 30679083 103 SVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLI 136
Cdd:cd19932  80 AYSQQDLVERA-KEAGAMAYLVKPFSESDLIPAI 112
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 24-118 1.76e-10

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 54.44  E-value: 1.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQ--TAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREmKVTSMIVGV 101
Cdd:cd17535   1 VLIVDDHPLVREGLRRLLESEPDIEVvgEAADGEEALALLR--ELRPDVVLMDLSMPGMDGIEALRRLRR-RYPDLKVIV 77

                        90
                ....*....|....*..
gi 30679083 102 TSVADQEEERKAFMEAG 118
Cdd:cd17535  78 LTAHDDPEYVLRALKAG 94
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 24-118 2.93e-10

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 53.67  E-value: 2.93e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMI--VGV 101
Cdd:cd19920   1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQA--LQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATRHIpvIFL 78

                        90
                ....*....|....*..
gi 30679083 102 TSVADQEEERKAFmEAG 118
Cdd:cd19920  79 TALTDTEDKVKGF-ELG 94
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 22-140 3.15e-10

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 53.82  E-value: 3.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRrlheMIIKTI---GG--ISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTS 96
Cdd:cd17542   1 KKVLIVDDAAFMR----MMLKDIltkAGyeVVGEAANGEEAVEKYK--ELKPDLVTMDITMPEMDGIEALKEIKKIDPNA 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30679083  97 MIVGVTSVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLISHLF 140
Cdd:cd17542  75 KVIMCSAMGQEEMVKEA-IKAGAKDFIVKPFQPERVLEAVEKVL 117
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
24-136 3.33e-10

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 56.78  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDgeASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFAD--IHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTA 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 30679083  104 VADQEEERKAFMEAGLNHCLeKPLTKAKIFPLI 136
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVI-KPFDLDELNLIV 116
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 24-126 1.05e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 52.39  E-value: 1.05e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKvTSMIVGVTS 103
Cdd:cd17627   1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEA--LRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAG-NDLPILVLT 77

                        90       100
                ....*....|....*....|...
gi 30679083 104 VADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17627  78 ARDSVSDRVAGLDAGADDYLVKP 100
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
22-103 1.29e-09

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 54.89  E-value: 1.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRR-LHEMI-----IKTIGgisqTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLreMKVT 95
Cdd:PRK12555   1 MRIGIVNDSPLAVEaLRRALardpdHEVVW----VATDGAQAVERCA--AQPPDVILMDLEMPRMDGVEATRRI--MAER 72


                 ....*....
gi 30679083   96 SM-IVGVTS 103
Cdd:PRK12555  73 PCpILIVTS 81
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 23-93 2.24e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 51.45  E-value: 2.24e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMK 93
Cdd:cd17554   2 KILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESED--PDLVILDIKMPGMDGLETLRKIREKK 70
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 23-127 2.44e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 51.65  E-value: 2.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQ--TAKNGEEAV-ILHRDGEASF----DLILMDKEMPERDGVSTTKKLREMKVT 95
Cdd:cd17557   1 TILLVEDNPGDAELIQEAFKEAGVPNElhVVRDGEEALdFLRGEGEYADaprpDLILLDLNMPRMDGFEVLREIKADPDL 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 30679083  96 SMI-VGVTSVADQEEERKAFMEAGLNHCLEKPL 127
Cdd:cd17557  81 RRIpVVVLTTSDAEEDIERAYELGANSYIVKPV 113
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 22-139 3.22e-09

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 51.38  E-value: 3.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLhemIIKTIGG-----ISQtAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTS 96
Cdd:cd17593   1 MKVLICDDSSMARKQ---LARALPAdwdveITF-AENGEEA--LEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLET 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30679083  97 MIVgVTSvAD-QEEERKAFMEAGLNHCLEKPLTKAKIFPLISHL 139
Cdd:cd17593  75 KVI-VVS-GDvQPEAKERVLELGALAFLKKPFDPEKLAQLLEEL 116
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 22-78 4.29e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 49.49  E-value: 4.29e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 30679083     22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMP 78
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLK--EEKPDLILLDIMMP 55
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 24-102 6.95e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 50.23  E-value: 6.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGIS--QTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:cd17532   1 ALIVDDEPLAREELRYLLEEHPDIEivGEAENGEEALEAIE--ELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFV 78


                .
gi 30679083 102 T 102
Cdd:cd17532  79 T 79
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 22-136 1.11e-08

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 51.11  E-value: 1.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIG-GISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVg 100
Cdd:COG3707   4 LRVLVVDDEPLRRADLREGLREAGyEVVAEAADGEDAVELVR--ELKPDLVIVDIDMPDRDGLEAARQISEERPAPVIL- 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30679083 101 VTSVADQEEERKAfMEAGLNHCLEKPLTKAKIFPLI 136
Cdd:COG3707  81 LTAYSDPELIERA-LEAGVSAYLVKPLDPEDLLPAL 115
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 23-142 1.44e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 51.87  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLRE----MKVTSmI 98
Cdd:PRK11091 527 NILLVEDIELNVIVARSVLEKLGNSVDVAMTGKEALEMFDPDE--YDLVLLDIQLPDMTGLDIARELREryprEDLPP-L 603

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 30679083   99 VGVTsvADQEEERKAFMEAGLNHCLEKPLTKAKIFPLISHLFDA 142
Cdd:PRK11091 604 VALT--ANVLKDKKEYLDAGMDDVLSKPLSVPALTAMIKKFWDT 645
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 24-129 1.67e-08

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 49.33  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEasFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:cd17616   1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYD--YDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSG 78

                        90       100
                ....*....|....*....|....*.
gi 30679083 104 VADQEEERKAFmEAGLNHCLEKPLTK 129
Cdd:cd17616  79 LADIEDKVKGL-GFGADDYMTKPFHK 103
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 24-128 2.17e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 49.22  E-value: 2.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREM---KVTSMIVG 100
Cdd:cd17562   3 ILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDA--LSKAQSKKFDLIITDQNMPNMDGIELIKELRKLpayKFTPILML 80

                        90       100
                ....*....|....*....|....*....
gi 30679083 101 VTSVADQ-EEERKAfmeAGLNHCLEKPLT 128
Cdd:cd17562  81 TTESSDEkKQEGKA---AGATGWLVKPFD 106
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 25-126 3.93e-08

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 48.37  E-value: 3.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  25 LIVDDDplnRRLHEMIIKTI---GGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:cd17625   1 LVVEDE---KDLSEAITKHLkkeGYTVDVCFDGEEG--LEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLL 75

                        90       100
                ....*....|....*....|....*
gi 30679083 102 TSVaDQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17625  76 TAL-DAVEDRVKGLDLGADDYLPKP 99
ompR PRK09468
osmolarity response regulator; Provisional
 24-126 5.59e-08

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 49.59  E-value: 5.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEA-VILHRDgeaSFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVT 102
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMdRLLTRE---SFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLT 84

                         90       100
                 ....*....|....*....|....
gi 30679083  103 SVADqEEERKAFMEAGLNHCLEKP 126
Cdd:PRK09468  85 AKGE-EVDRIVGLEIGADDYLPKP 107
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 26-127 7.99e-08

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 47.27  E-value: 7.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  26 IVDDDPLNRRLHEMIIKT--IGGISQTAKNGEEAvilhrDGEASF---DLILMDKEMPERDGVSTTKKLREMKVTSMIVG 100
Cdd:cd17565   3 IVDDDKNIIKILSDIIEDddLGEVVGEADNGAQA-----YDEILFlqpDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIM 77

                        90       100
                ....*....|....*....|....*..
gi 30679083 101 VTSVADQEEERKAFmEAGLNHCLEKPL 127
Cdd:cd17565  78 ISQVSDKEMIGKAY-QAGIEFFINKPI 103
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 24-126 8.11e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 47.37  E-value: 8.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVIL-------HRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTS 96
Cdd:cd19924   1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKlenlakeGNDLSKELDLIITDIEMPKMDGYELTFELRDDPRLA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 30679083  97 MI--VGVTSVADQEEERKAfMEAGLNHCLEKP 126
Cdd:cd19924  81 NIpvILNSSLSGEFSRARG-KKVGADAYLAKF 111
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 23-127 8.12e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 47.38  E-value: 8.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgVT 102
Cdd:cd17619   2 HILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEM--RQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIIL-VT 78

                        90       100
                ....*....|....*....|....*
gi 30679083 103 SvADQEEERKAFMEAGLNHCLEKPL 127
Cdd:cd17619  79 G-RDDEVDRIVGLEIGADDYVTKPF 102
PRK10430 PRK10430
two-component system response regulator DcuR;
21-126 1.01e-07

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 48.95  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   21 LINVLIVDDDPLNRRLHEMIIKTIGGIS--QTAKNGEEAVILHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMI 98
Cdd:PRK10430   1 MINVLIVDDDAMVAELNRRYVAQIPGFQccGTASTLEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSDV 80

                         90       100
                 ....*....|....*....|....*...
gi 30679083   99 VGVTSVADQEEERKAfMEAGLNHCLEKP 126
Cdd:PRK10430  81 IVISSAADAATIKDS-LHYGVVDYLIKP 107
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 24-140 1.06e-07

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 47.24  E-value: 1.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIvgVTS 103
Cdd:cd17584   1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKDEFDLVITDVHMPDMDGFEFLELIRLEMDLPVI--MMS 78

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 30679083 104 VADQEEERKAFMEAGLNHCLEKPLTKAKIFPLISHLF 140
Cdd:cd17584  79 ADGSTSTVMKGLAHGACDYLLKPVSIEDLKNIWQHVV 115
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 24-141 1.10e-07

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 47.11  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:cd17550   1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEA--LKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISG 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 30679083 104 VADQEEERKAfMEAGLNHCLEKPLTKAKIFPLISHLFD 141
Cdd:cd17550  79 HGTIETAVKA-TKLGAYDFIEKPLSLDRLLLTIERALE 115
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
22-99 1.42e-07

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 48.99  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRR-LHEMI-----IKTIGgisqTAKNGEEAV--ILhrdgEASFDLILMDKEMPERDGVSTTKKLreMK 93
Cdd:PRK00742   4 IRVLVVDDSAFMRRlISEILnsdpdIEVVG----TAPDGLEARekIK----KLNPDVITLDVEMPVMDGLDALEKI--MR 73


                 ....*.
gi 30679083   94 VTSMIV 99
Cdd:PRK00742  74 LRPTPV 79
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
24-125 1.76e-07

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 48.31  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgVTS 103
Cdd:PRK10403   9 VLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQII-ILT 87

                         90       100
                 ....*....|....*....|..
gi 30679083  104 VADQEEERKAFMEAGLNHCLEK 125
Cdd:PRK10403  88 VSDASSDVFALIDAGADGYLLK 109
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 23-137 2.04e-07

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 46.67  E-value: 2.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGIS-QTAKNGEEAVILHRDGeaSFDLILMDKEMPERDGVSTTKKLREMK---VTSMI 98
Cdd:cd17530   2 RVLVLDDDPFQCMMAATILEDLGPGNvDEADDGREALVILLCN--APDIIICDLKMPDMDGIEFLRHLAESHsnaAVILM 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 30679083  99 VGVTSVADQEEERKAfMEAGLN--HCLEKPLTKAKIFPLIS 137
Cdd:cd17530  80 SGLDGGILESAETLA-GANGLNllGTLSKPFSPEELTELLT 119
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 24-126 2.14e-07

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 46.34  E-value: 2.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEAsFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:cd18160   2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKD-IDIVVTDIVMPEMDGIELAREARKIDPDVKILFISG 80

                        90       100
                ....*....|....*....|...
gi 30679083 104 VADQEEERKAFMEAGlNHCLEKP 126
Cdd:cd18160  81 GAAAAPELLSDAVGD-NATLKKP 102
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 24-132 2.37e-07

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 46.56  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRR-LHEMI------IKTIGgisqTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTS 96
Cdd:cd17536   1 VLIVDDEPLIREgLKKLIdweelgFEVVG----EAENGEEA--LELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDI 74

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30679083  97 MIVGVTSVADQEEERKAfMEAGLNHCLEKPLTKAKI 132
Cdd:cd17536  75 KIIILSGYDDFEYAQKA-IRLGVVDYLLKPVDEEEL 109
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 24-118 2.41e-07

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 46.19  E-value: 2.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGIS--QTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgV 101
Cdd:cd19931   1 VLLIDDHPLLRKGIKQLIELDPDFTvvGEASSGEEGIELAE--RLDPDLILLDLNMKGMSGLDTLKALREEGVSARIV-I 77

                        90
                ....*....|....*..
gi 30679083 102 TSVADQEEERKAFMEAG 118
Cdd:cd19931  78 LTVSDAEDDVVTALRAG 94
pleD PRK09581
response regulator PleD; Reviewed
 24-126 3.24e-07

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 47.97  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEAsfDLILMDKEMPERDGVSTTKKLREMKVTSMI--VGV 101
Cdd:PRK09581   5 ILVVDDIPANVKLLEAKLLAEYYTVLTASSGAEAIAICEREQP--DIILLDVMMPGMDGFEVCRRLKSDPATTHIpvVMV 82

                         90       100
                 ....*....|....*....|....*
gi 30679083  102 TSVaDQEEERKAFMEAGLNHCLEKP 126
Cdd:PRK09581  83 TAL-DDPEDRVRGLEAGADDFLTKP 106
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 24-126 3.30e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 46.01  E-value: 3.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGG-ISQTAKNGEEAV-ILHRDGEasfDLILMDKEMPERDGVSTTKKLREMKVTSMI--V 99
Cdd:cd17552   4 ILVIDDEEDIREVVQACLEKLAGwEVLTASSGQEGLeKAATEQP---DAILLDVMMPDMDGLATLKKLQANPETQSIpvI 80

                        90       100
                ....*....|....*....|....*..
gi 30679083 100 GVTSVAdQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17552  81 LLTAKA-QPSDRQRFASLGVAGVIAKP 106
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 22-126 3.54e-07

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 45.97  E-value: 3.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRR-LHEMI----IKTIggisqTAKNGEEAV-ILHRDGEasFDLILMDKEMPERDGVSTTKKLRE-MKV 94
Cdd:cd17544   1 IKVLVVDDSATSRNhLRALLrrhnFQVL-----EAANGQEALeVLEQHPD--IKLVITDYNMPEMDGFELVREIRKkYSR 73

                        90       100       110
                ....*....|....*....|....*....|...
gi 30679083  95 TSM-IVGVTSVADQEEERKaFMEAGLNHCLEKP 126
Cdd:cd17544  74 DQLaIIGISASGDNALSAR-FIKAGANDFLTKP 105
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 22-108 4.40e-07

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 45.48  E-value: 4.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGG-ISQTAKNGEEAVILHRdgEASFDLILMDKEMP-ERDGVSTTKKLREMKVTSmIV 99
Cdd:cd17534   1 KKILIVEDEAIIALDLKEILESLGYeVVGIADSGEEAIELAE--ENKPDLILMDINLKgDMDGIEAAREIREKFDIP-VI 77


                ....*....
gi 30679083 100 GVTSVADQE 108
Cdd:cd17534  78 FLTAYSDEE 86
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
24-129 8.52e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 46.33  E-value: 8.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDgeaSFDLILMDKEMPERDGVSTTKKLREMKVTSMIvgVTS 103
Cdd:PRK10955   4 ILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDD---SIDLLLLDVMMPKKNGIDTLKELRQTHQTPVI--MLT 78

                         90       100
                 ....*....|....*....|....*.
gi 30679083  104 VADQEEERKAFMEAGLNHCLEKPLTK 129
Cdd:PRK10955  79 ARGSELDRVLGLELGADDYLPKPFND 104
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 24-126 1.17e-06

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 43.97  E-value: 1.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDP-----LNRRLHEMiiktiGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMI 98
Cdd:cd19935   1 ILVVEDEKklaeyLKKGLTEE-----GYAVDVAYDGEDG--LHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPV 73

                        90       100
                ....*....|....*....|....*...
gi 30679083  99 VGVTSvADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd19935  74 LMLTA-RDSVEDRVKGLDLGADDYLVKP 100
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
22-127 1.30e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 46.18  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:PRK10365   6 IDILVVDDDISHCTILQALLRGWGYNVALANSGRQA--LEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIM 83

                         90       100
                 ....*....|....*....|....*.
gi 30679083  102 TSVADQEEERKAFMEAGLNHcLEKPL 127
Cdd:PRK10365  84 TAYSSVETAVEALKTGALDY-LIKPL 108
PRK09483 PRK09483
response regulator; Provisional
 21-89 1.36e-06

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 45.87  E-value: 1.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30679083   21 LINVLIVDDDPLNRRLHEMIIKTIGGISQT--AKNGEEAVILHRDGEAsfDLILMDKEMPERDGVSTTKKL 89
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIKGIKVVgeACCGEDAVKWCRTNAV--DVVLMDMNMPGIGGLEATRKI 69
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 24-138 1.44e-06

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 46.44  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEAsFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:PRK11466 684 LLLIEDNPLTQRITAEMLNTSGAQVVAVGNAAQALETLQNSEP-FAAALVDFDLPDYDGITLARQLAQQYPSLVLIGFSA 762

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 30679083  104 --VADQEEERKAFMEAGLnhcLEKPLTKAKIFPLISH 138
Cdd:PRK11466 763 hvIDETLRQRTSSLFRGI---IPKPVPREVLGQLLAH 796
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 24-136 2.49e-06

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 43.59  E-value: 2.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgVTS 103
Cdd:cd17594   2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLML--HRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIII-ISG 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 30679083 104 VADQEEERKAFMEAGLNHCLEKPLTKAKIFPLI 136
Cdd:cd17594  79 DRRDEIDRVVGLELGADDYLAKPFGLRELLARV 111
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 24-126 2.54e-06

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 43.50  E-value: 2.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEAsfDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTS 103
Cdd:cd17615   2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRP--DAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTA 79

                        90       100
                ....*....|....*....|...
gi 30679083 104 vADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17615  80 -KDSVEDRIAGLTAGGDDYVTKP 101
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 25-98 3.76e-06

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 43.03  E-value: 3.76e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30679083  25 LIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDgeASFDLILMDKEMPERDGVSTTKKLREMKVTSMI 98
Cdd:cd19937   1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKD--EKPDLIILDLMLPGIDGLEVCRILRSDPKTSSI 72
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 22-126 5.44e-06

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 42.60  E-value: 5.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  22 INVLIVDDdplNRRLHEMIIKTIGG-----ISQTAKNGEEAVILHRDGEAsfDLILMDKEMPERDGVSTTKKLREMKVTS 96
Cdd:cd17561   2 IKVLIADD---NREFVQLLEEYLNSqpdmeVVGVAHNGQEALELIEEKEP--DVLLLDIIMPHLDGIGVLEKLRRMRLEK 76

                        90       100       110
                ....*....|....*....|....*....|..
gi 30679083  97 M--IVGVTSVAdQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17561  77 RpkIIMLTAFG-QEDITQRAVELGASYYILKP 107
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 24-126 1.20e-05

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 41.91  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDplnRRLHEMIIKTIG--GIS-QTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLRemKVTSMIVG 100
Cdd:cd17623   1 ILLIDDD---RELTELLTEYLEmeGFNvRAAHDGEQG--LAALLEGSPDLVVLDVMLPKMNGLDVLKELR--KTSQVPVL 73

                        90       100
                ....*....|....*....|....*.
gi 30679083 101 VTSVADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17623  74 MLTARGDDIDRILGLELGADDYLPKP 99
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 24-127 1.26e-05

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 41.92  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDdplNRRLHEMIIKTIGGISQ--TAKNGEEAVIlhRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMiVGV 101
Cdd:cd17539   1 VLLVDD---RPSSAERIAAMLSSEHEvvVEADPDEALF--RAAEGPFDLVIVSLALEDFDGLRLCSQLRSLERTRQ-LPI 74

                        90       100
                ....*....|....*....|....*...
gi 30679083 102 TSVADQEEERKAF--MEAGLNHCLEKPL 127
Cdd:cd17539  75 LAVADPGDRGRLIraLEIGVNDYLVRPI 102
orf27 CHL00148
Ycf27; Reviewed
 24-107 1.51e-05

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 42.78  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLR-EMKV-TSMIVGV 101
Cdd:CHL00148   9 ILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFR--KEQPDLVILDVMMPKLDGYGVCQEIRkESDVpIIMLTAL 86


                 ....*.
gi 30679083  102 TSVADQ 107
Cdd:CHL00148  87 GDVSDR 92
PRK10610 PRK10610
chemotaxis protein CheY;
20-141 1.61e-05

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 41.88  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   20 KLINVLIVDDDPLNRRLHEMIIKTIG-GISQTAKNGEEAVILHRDGeaSFDLILMDKEMPERDGVSTTKKLRE-MKVTSM 97
Cdd:PRK10610   4 KELKFLVVDDFSTMRRIVRNLLKELGfNNVEEAEDGVDALNKLQAG--GFGFVISDWNMPNMDGLELLKTIRAdGAMSAL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 30679083   98 IVGVTSVADQEEERKAFMEAGLNHCLEKPLTKAKIFPLISHLFD 141
Cdd:PRK10610  82 PVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFE 125
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 50-119 1.63e-05

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 41.49  E-value: 1.63e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  50 TAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVTSVADQEEERKAfMEAGL 119
Cdd:cd19930  29 QASNGQEALRLVL--KHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRA-LAAGV 95
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 23-126 2.02e-05

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 41.08  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDgeASFDLILMDKEMPERDGVSTTKKLREMKVTSMI--VG 100
Cdd:cd17618   2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVE--PRPDLILLDWMLPGGSGIQFIRRLKRDEMTRDIpiIM 79

                        90       100
                ....*....|....*....|....*.
gi 30679083 101 VTSVADqEEERKAFMEAGLNHCLEKP 126
Cdd:cd17618  80 LTARGE-EEDKVRGLEAGADDYITKP 104
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 24-126 3.88e-05

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 40.34  E-value: 3.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDD-PLNRRLHEMIIKTiGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVT 102
Cdd:cd19934   1 LLLVEDDaLLAAQLKEQLSDA-GYVVDVAEDGEEA--LFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77

                        90       100
                ....*....|....*....|....
gi 30679083 103 SvADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd19934  78 A-RDSWQDKVEGLDAGADDYLTKP 100
PRK15115 PRK15115
response regulator GlrR; Provisional
 18-84 5.53e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 41.75  E-value: 5.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30679083   18 KKKLINVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAV-ILHRDgeaSFDLILMDKEMPERDGVS 84
Cdd:PRK15115   2 SRKPAHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALrVLNRE---KVDLVISDLRMDEMDGMQ 66
dpiA PRK10046
two-component response regulator DpiA; Provisional
 22-132 1.12e-04

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 40.39  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   22 INVLIVDDDPLNRRLHEMIIKTIGGISQT--AKNGEEAVILHRDGEASfdLILMDKEMPERDGVSTTKKLREMKVTSMIV 99
Cdd:PRK10046   5 LTLLIVEDETPLAEMHAEYIRHIPGFSQIllAGNLAQARMMIERFKPG--LILLDNYLPDGRGINLLHELVQAHYPGDVV 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 30679083  100 GVTSVADQEEERKAFMEAGLNHcLEKPLTKAKI 132
Cdd:PRK10046  83 FTTAASDMETVSEAVRCGVFDY-LIKPIAYERL 114
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 24-141 1.14e-04

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 39.63  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDP-----LNRRLHEMIIKTIGGISqtAKNGEEAVI----LHRDGEASfDLILMDKEMPERDGVSTTKKLREMKV 94
Cdd:cd17595   3 ILTVDDDPqvlraVARDLRRQYGKDYRVLR--ADSGAEALDalkeLKLRGEAV-ALFLVDQRMPEMDGVEFLEKAMELFP 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30679083  95 TSMIVGVTSVADQEEERKAFMEAGLNHCLEKPL--TKAKIFPLISHLFD 141
Cdd:cd17595  80 EAKRVLLTAYADTDAAIRAINDVQLDYYLLKPWdpPEEKLYPVLDDLLD 128
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 23-126 1.63e-04

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 39.79  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   23 NVLIVDDDPLNRRLHEMIIKTIGGI---SQTAKNGeeaviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIv 99
Cdd:PRK10529   3 NVLIVEDEQAIRRFLRTALEGDGMRvfeAETLQRG-----LLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVI- 76

                         90       100
                 ....*....|....*....|....*..
gi 30679083  100 gVTSVADQEEERKAFMEAGLNHCLEKP 126
Cdd:PRK10529  77 -VLSARSEESDKIAALDAGADDYLSKP 102
PRK13557 PRK13557
histidine kinase; Provisional
 24-111 2.02e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 40.04  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAV-ILhrDGEASFDLILMDKEMP-ERDGVSTTKKLREMKVTSMIVGV 101
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDFGYRTLVASNGREALeIL--DSHPEVDLLFTDLIMPgGMNGVMLAREARRRQPKIKVLLT 495

                         90
                 ....*....|
gi 30679083  102 TSVADQEEER 111
Cdd:PRK13557 496 TGYAEASIER 505
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 24-78 2.21e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 38.10  E-value: 2.21e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAV-ILHRDgeASFDLILMDKEMP 78
Cdd:cd18161   1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALdLLESG--PDIDLLVTDVIMP 54
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 24-126 2.22e-04

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 38.46  E-value: 2.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDGEASfdLILMDKEMPERDGVSTTKKLRE---MKVTSMIVg 100
Cdd:cd17598   1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPT--LVISDIVMPEMDGYELCRKIKSdpdLKDIPVIL- 77

                        90       100
                ....*....|....*....|....*.
gi 30679083 101 VTSVADQEEERKAfMEAGLNHCLEKP 126
Cdd:cd17598  78 LTTLSDPRDVIRG-LECGADNFITKP 102
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 24-126 4.73e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 37.73  E-value: 4.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGIsQTAKNGEEAVILHRDGEAsfDLILMDKEMPERDGVSTTKKLREM--KVTSMIvgV 101
Cdd:cd17596   3 ILVVDDEVRSLEALRRTLEEDFDV-LTAASAEEALAILEEEWV--QVILCDQRMPGTTGVEFLKEVRERwpEVVRII--I 77

                        90       100
                ....*....|....*....|....*
gi 30679083 102 TSVADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17596  78 SGYTDSEDIIAGINEAGIYQYLTKP 102
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 22-91 5.17e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 37.38  E-value: 5.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30679083  22 INVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAV-ILHRDgeaSFDLILMDKEMPERDGVSTTKKLRE 91
Cdd:cd17569   1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALeILKQE---PVDVVISDQRMPGMDGAELLKRVRE 68
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 24-91 5.61e-04

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 36.97  E-value: 5.61e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLRE 91
Cdd:cd19927   1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLN--QYIPDLIISDIIMPGVDGYSLLGKLRK 66
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 23-126 5.83e-04

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 37.97  E-value: 5.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRDgeASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGVT 102
Cdd:COG4567   6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQ--APPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83

                        90       100
                ....*....|....*....|....*..
gi 30679083 103 ---SVADQEEERKafmeAGLNHCLEKP 126
Cdd:COG4567  84 gyaSIATAVEAIK----LGADDYLAKP 106
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 24-91 1.17e-03

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 36.41  E-value: 1.17e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLRE 91
Cdd:cd17555   3 ILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFR--SEQPDLVLCDLRMPEMDGLEVLKQITK 68
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 24-126 2.25e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 35.48  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLRemKVTSMIVGVTS 103
Cdd:cd17614   1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREA--LEKVEEEQPDLILLDLMLPEKDGLEVCREVR--KTSNVPIIMLT 76

                        90       100
                ....*....|....*....|...
gi 30679083 104 VADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17614  77 AKDSEVDKVLGLELGADDYVTKP 99
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
23-106 2.73e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 36.41  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   23 NVLIVDDDPLNR-RLHEMIIKTigGISQTAKNGEEAVILHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVGV 101
Cdd:PRK09958   2 NAIIIDDHPLAIaAIRNLLIKN--DIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIV 79


                 ....*
gi 30679083  102 TSVAD 106
Cdd:PRK09958  80 SAKND 84
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 23-105 2.81e-03

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 35.11  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  23 NVLIVDDDP---------LNRRlhemiiktiGGISQTAKNGEEAVILHRdgEASFDLILMDKEMPERDGVSTTKKLREMK 93
Cdd:cd17563   2 SLLLVDDDEvfaerlaraLERR---------GFEVETAHSVEEALALAR--EEKPDYAVLDLRLGGDSGLDLIPPLRALQ 70

                        90
                ....*....|....*
gi 30679083  94 VTSMIVGVT---SVA 105
Cdd:cd17563  71 PDARIVVLTgyaSIA 85
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 24-126 4.31e-03

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 34.77  E-value: 4.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083  24 VLIVDDDPLNRRLHEMIIKTIGGISQTAKNGEEAviLHRDGEASFDLILMDKEMPERDGVSTTKKLREMKVTSMIVgVTS 103
Cdd:cd17624   1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEA--EAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVL-ILT 77

                        90       100
                ....*....|....*....|...
gi 30679083 104 VADQEEERKAFMEAGLNHCLEKP 126
Cdd:cd17624  78 ARDGVDDRVAGLDAGADDYLVKP 100
PRK10766 PRK10766
two-component system response regulator TorR;
23-91 4.72e-03

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 35.78  E-value: 4.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30679083   23 NVLIVDDDPLNR-RLHEMIIKTIGGISQTAKNGEEAVILHRdgeASFDLILMDKEMPERDGVSTTKKLRE 91
Cdd:PRK10766   4 HILVVEDEPVTRaRLQGYFEQEGYTVSEAASGAGMREIMQN---QHVDLILLDINLPGEDGLMLTRELRS 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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