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    ZIF1 zinc induced facilitator 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831219, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZIF1
    Official Full Name
    zinc induced facilitator 1
    Primary source
    TAIR:AT5G13740
    Locus tag
    AT5G13740
    See related
    Araport:AT5G13740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MSH12.21; MSH12_21; zinc induced facilitator 1
    Summary
    Encodes ZIF1 (ZINC-INDUCED FACILITATOR1), a member of the Major Facilitator Superfamily (MFS) of membrane proteins which are found in all organisms and transport a wide range of small, organic molecules. Involved in a mechanism of Zn sequestration, possibly by transport of a Zn ligand or Zn-ligand complex into vacuoles.
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    Genomic context

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    See ZIF1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (4432297..4437148)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene sterol methyltransferase 1 Neighboring gene Uncharacterized protein family (UPF0114) Neighboring gene sigma factor 4 Neighboring gene zinc induced facilitator-like 1 Neighboring gene Plasma-membrane choline transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vacuolar nicotianamine has critical and distinct roles under iron deficiency and for zinc sequestration in Arabidopsis. Haydon MJ, et al. Plant Cell, 2012 Feb. PMID 22374397, Free PMC Article
    2. A novel major facilitator superfamily protein at the tonoplast influences zinc tolerance and accumulation in Arabidopsis. Haydon MJ, et al. Plant Physiol, 2007 Apr. PMID 17277087, Free PMC Article
    3. Functional overlap of two major facilitator superfamily transporter, ZIF1, and ZIFL1 in zinc and iron homeostasis. Lee S, et al. Biochem Biophys Res Commun, 2021 Jun 30. PMID 33964505
    4. Nematode-induced changes of transporter gene expression in Arabidopsis roots. Hammes UZ, et al. Mol Plant Microbe Interact, 2005 Dec. PMID 16478044
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_121377.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    acts_upstream_of_or_within response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc induced facilitator 1
    NP_196878.2
    • zinc induced facilitator 1 (ZIF1); FUNCTIONS IN: carbohydrate transmembrane transporter activity, tetracycline:hydrogen antiporter activity, sugar:hydrogen symporter activity; INVOLVED IN: response to zinc ion, zinc ion homeostasis, response to nematode; LOCATED IN: plant-type vacuole membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Major facilitator superfamily (InterPro:IPR020846), Tetracycline resistance protein, TetA (InterPro:IPR001958), Major facilitator superfamily MFS-1 (InterPro:IPR011701), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: zinc induced facilitator-like 1 (TAIR:AT5G13750.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4432297..4437148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343291.1 → NP_001331803.1  zinc induced facilitator 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UIX9, A0A1P8BEY5, A0A5S9Y3V4

    2. NM_121377.5 → NP_196878.2  zinc induced facilitator 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196878.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RWN2, Q9FKI8
      UniProtKB/TrEMBL
      A0A178UIX9, A0A5S9Y3V4, A0A654G0R7
      Conserved Domains (1) summary
      cd17330
      Location:42 → 444
      MFS_SLC46_TetA_like; Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWN2.2

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