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    KRT82 keratin 82 [ Homo sapiens (human) ]

    Gene ID: 3888, updated on 10-Dec-2024

    Summary

    Official Symbol
    KRT82provided by HGNC
    Official Full Name
    keratin 82provided by HGNC
    Primary source
    HGNC:HGNC:6459
    See related
    Ensembl:ENSG00000161850 MIM:601078; AllianceGenome:HGNC:6459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HB2; Hb-2; KRTHB2
    Summary
    The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See KRT82 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52393931..52406335, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52357844..52370247, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52787715..52800119, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52763817-52764316 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28991 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28997 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28998 Neighboring gene keratin 84 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52789485-52789986 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29013 Neighboring gene keratin 90, pseudogene Neighboring gene keratin 75

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in intermediate filament organization  
    involved_in keratinization  
    Component Evidence Code Pubs
    located_in cytosol  
    is_active_in keratin filament  
    located_in keratin filament PubMed 
    located_in keratin filament PubMed 

    General protein information

    Preferred Names
    keratin, type II cuticular Hb2
    Names
    K82
    hard keratin, type II, 2
    keratin 82, type II
    keratin, hair, basic, 2
    type II hair keratin Hb2
    type-II keratin Kb22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012298.1 RefSeqGene

      Range
      5058..17462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_033033.4 → NP_149022.3  keratin, type II cuticular Hb2

      See identical proteins and their annotated locations for NP_149022.3

      Status: REVIEWED

      Source sequence(s)
      AC078865
      Consensus CDS
      CCDS8826.1
      UniProtKB/Swiss-Prot
      Q9NSB4
      UniProtKB/TrEMBL
      Q701L7
      Related
      ENSP00000257974.3, ENST00000257974.3
      Conserved Domains (3) summary
      pfam00038
      Location:120 → 430
      Filament; Intermediate filament protein
      pfam16208
      Location:61 → 116
      Keratin_2_head; Keratin type II head
      cl12057
      Location:327 → 396
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52393931..52406335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52357844..52370247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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