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KRT15 keratin 15 [ Homo sapiens (human) ]

Gene ID: 3866, updated on 27-Nov-2024

Summary

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Official Symbol
KRT15provided by HGNC
Official Full Name
keratin 15provided by HGNC
Primary source
HGNC:HGNC:6421
See related
Ensembl:ENSG00000171346 MIM:148030; AllianceGenome:HGNC:6421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K15; CK15; K1CO
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 317.3), esophagus (RPKM 283.6) and 1 other tissue See more
Orthologs
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Genomic context

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See KRT15 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41513745..41518890, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42369289..42379059, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39669997..39675142, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39642150-39643103 Neighboring gene keratin 36 Neighboring gene keratin 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39672893-39673777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39675482-39676481 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:39677595-39678794 Neighboring gene microRNA 6510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39683757-39684456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39684457-39685154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39685155-39685852 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2493 Neighboring gene keratin 19 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39695425-39696045 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39705412-39706025 Neighboring gene long intergenic non-protein coding RNA 974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39708567-39709067

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization. Barletta C, et al. Cytogenet Cell Genet, 1990. PMID 1702379
  2. Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain. Tommasi C, et al. Virol J, 2024 Oct 9. PMID 39385182, Free PMC Article
  3. Cytokeratin 15 is an Effective Indicator for Progression and Malignancy of Esophageal Squamous Cell Carcinomas. Shen YH, et al. Asian Pac J Cancer Prev, 2016. PMID 27797221
  4. Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles. Sperling LC, et al. J Cutan Pathol, 2011 May. PMID 21251039
  5. Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro. Tiede S, et al. Eur J Cell Biol, 2010 Oct. PMID 20656376

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain.
    Title: Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain.
  2. Tumor keratin 15 expression links with less extent of invasion and better prognosis in papillary thyroid cancer patients receiving tumor resection.
    Title: Tumor keratin 15 expression links with less extent of invasion and better prognosis in papillary thyroid cancer patients receiving tumor resection.
  3. Upregulated keratin 15 links to the occurrence of lymphovascular invasion, stromal cervical invasion as well as unfavorable survival profile in endometrial cancer patients.
    Title: Upregulated keratin 15 links to the occurrence of lymphovascular invasion, stromal cervical invasion as well as unfavorable survival profile in endometrial cancer patients.
  4. KRT15 promotes colorectal cancer cell migration and invasion through beta-catenin/MMP-7 signaling pathway.
    Title: KRT15 promotes colorectal cancer cell migration and invasion through β-catenin/MMP-7 signaling pathway.
  5. KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma.
    Title: KRT 15 as a prognostic biomarker is highly expressed in esophageal carcinoma.
  6. Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk.
    Title: Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk.
  7. KRT15 overexpression predicts poor prognosis in colorectal cancer.
    Title: KRT15 overexpression predicts poor prognosis in colorectal cancer.
  8. BerEP4 differentiates between microcystic adnexal carcinoma and morpheaform basal cell carcinoma.
    Title: The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.
  9. The protein CK15 can be used for the differential diagnosis between high-grade dysplasia and oral epithelial malignancy at the stage of carcinoma in situ and squamous cell carcinoma.
    Title: Immunohistochemical study of Ki-67, PHH3, and CK15 protein expression in oral epithelial malignancy.
  10. Underexpression of CK15 is associated with Esophageal Squamous Cell Carcinomas.
    Title: Cytokeratin 15 is an Effective Indicator for Progression and Malignancy of Esophageal Squamous Cell Carcinomas.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in epidermis development TAS
Traceable Author Statement
more info
 PubMed 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
keratin, type I cytoskeletal 15
Names
CK-15
cytokeratin 15
keratin 15, type I
keratin-15, basic
keratin-15, beta
type I cytoskeletal 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012284.2 RefSeqGene

    Range
    5000..10145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002275.4 → NP_002266.3  keratin, type I cytoskeletal 15

    Status: REVIEWED

    Source sequence(s)
    AC019349
    Consensus CDS
    CCDS11398.1
    UniProtKB/Swiss-Prot
    B3KQY1, B3KRA2, E0CX14, P19012, Q53XV8, Q9BUG4
    UniProtKB/TrEMBL
    B3KVF5
    Related
    ENSP00000254043.3, ENST00000254043.8
    Conserved Domains (1) summary
    pfam00038
    Location:104 → 416
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41513745..41518890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524784.4 → XP_011523086.1  keratin, type I cytoskeletal 15 isoform X1

    UniProtKB/TrEMBL
    B3KVF5
    Conserved Domains (1) summary
    pfam00038
    Location:104 → 423
    Filament; Intermediate filament protein

  2. XM_017024614.3 → XP_016880103.1  keratin, type I cytoskeletal 15 isoform X2

    UniProtKB/TrEMBL
    B3KVF5
    Conserved Domains (1) summary
    pfam00038
    Location:104 → 423
    Filament; Intermediate filament protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42369289..42379059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316023.1 → XP_054171998.1  keratin, type I cytoskeletal 15 isoform X3

  2. XM_054316022.1 → XP_054171997.1  keratin, type I cytoskeletal 15 isoform X1

  3. XM_054316024.1 → XP_054171999.1  keratin, type I cytoskeletal 15 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19012.3 GenPept UniProtKB/Swiss-Prot:P19012

Gene LinkOut

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