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    ZHX3 zinc fingers and homeoboxes 3 [ Homo sapiens (human) ]

    Gene ID: 23051, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZHX3provided by HGNC
    Official Full Name
    zinc fingers and homeoboxes 3provided by HGNC
    Primary source
    HGNC:HGNC:15935
    See related
    Ensembl:ENSG00000174306 MIM:609598; AllianceGenome:HGNC:15935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIX1
    Summary
    This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 8.0), brain (RPKM 7.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZHX3 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (41178455..41317731, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (42910141..43049531, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (39807095..39946371, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PLCG1 antisense RNA 1 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39764698-39765482 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:39766267-39767051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39774494-39774994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39774995-39775495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39786713-39787233 Neighboring gene phospholipase C gamma 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17891 Neighboring gene microRNA 6871 Neighboring gene ribosomal protein L23a pseudogene 81 Neighboring gene RNA, 7SL, cytoplasmic 615, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17893 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:39962705-39962931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:39975675-39976198 Neighboring gene acireductone dioxygenase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39986695-39987302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:39987303-39987910 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation. Igata T, et al. PLoS One, 2022. PMID 35085309, Free PMC Article
    2. Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation. Suehiro F, et al. Stem Cells Dev, 2011 Sep. PMID 21174497
    3. ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21. Deng M, et al. Cancer Sci, 2021 May. PMID 33440047, Free PMC Article
    4. Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma. Kwon RJ, et al. PLoS One, 2017. PMID 28152006, Free PMC Article
    5. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. Kawata H, et al. Gene, 2003 Dec 24. PMID 14659886

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation.
      Title: Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation.
    2. ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21.
      Title: ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21.
    3. ZHX3 expression in renal cell carcinoma
      Title: Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.
    4. ZHX3 is involved in the switch from the undifferentiated state of mesenchymal stem cells to an osteogenic program
      Title: Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation.
    5. ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease
      Title: ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
    6. dimerizes with both ZHX1 and ZHX3, also interacts with the activation domain of the NF-YA
      Title: Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0395

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc fingers and homeoboxes protein 3
    Names
    triple homeobox 1
    triple homeobox protein 1
    zinc finger and homeodomain protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046923.1 RefSeqGene

      Range
      4888..144164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384315.1 → NP_001371244.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    2. NM_001384316.1 → NP_001371245.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Related
      ENSP00000452965.1, ENST00000559234.5
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    3. NM_001384317.1 → NP_001371246.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Related
      ENSP00000506788.1, ENST00000683867.1
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    4. NM_001384318.1 → NP_001371247.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    5. NM_001384319.1 → NP_001371248.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    6. NM_001384320.1 → NP_001371249.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    7. NM_001384321.1 → NP_001371250.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    8. NM_001384322.1 → NP_001371251.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    9. NM_001384323.1 → NP_001371252.1  zinc fingers and homeoboxes protein 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Related
      ENSP00000454006.1, ENST00000560361.5
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    10. NM_001384324.1 → NP_001371253.1  zinc fingers and homeoboxes protein 3 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL022394, AL031257
      Consensus CDS
      CCDS93040.1
      UniProtKB/TrEMBL
      A8K8Q0
      Related
      ENSP00000443783.2, ENST00000544979.6
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 891
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    11. NM_001384325.1 → NP_001371254.1  zinc fingers and homeoboxes protein 3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL022394, AL031257
      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    12. NM_015035.4 → NP_055850.1  zinc fingers and homeoboxes protein 3 isoform a

      See identical proteins and their annotated locations for NP_055850.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AB081948, AL022394, AL031257, BI458686
      Consensus CDS
      CCDS13315.1
      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0
      Related
      ENSP00000415498.3, ENST00000432768.6
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      41178455..41317731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440045.1 → XP_047296001.1  zinc fingers and homeoboxes protein 3 isoform X3

      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0

    2. XM_005260341.5 → XP_005260398.1  zinc fingers and homeoboxes protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 891
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    3. XM_047440044.1 → XP_047296000.1  zinc fingers and homeoboxes protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K8Q0

    4. XM_047440046.1 → XP_047296002.1  zinc fingers and homeoboxes protein 3 isoform X3

      UniProtKB/Swiss-Prot
      E1P5W5, F5H820, O43145, Q6NUJ7, Q9H4I2
      UniProtKB/TrEMBL
      A8K8Q0

    5. XM_047440036.1 → XP_047295992.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    6. XM_047440037.1 → XP_047295993.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    7. XM_047440039.1 → XP_047295995.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    8. XM_011528704.4 → XP_011527006.1  zinc fingers and homeoboxes protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011527006.1

      UniProtKB/TrEMBL
      A8K8Q0
      Conserved Domains (4) summary
      smart00389
      Location:621 → 666
      HOX; Homeodomain
      cd00086
      Location:500 → 553
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:850 → 892
      Homez; Homeodomain leucine-zipper encoding, Homez
      pfam18387
      Location:105 → 157
      zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

    9. XM_047440040.1 → XP_047295996.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    10. XM_047440038.1 → XP_047295994.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    11. XM_047440041.1 → XP_047295997.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    12. XM_047440042.1 → XP_047295998.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    13. XM_047440043.1 → XP_047295999.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      42910141..43049531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323243.1 → XP_054179218.1  zinc fingers and homeoboxes protein 3 isoform X3

      UniProtKB/TrEMBL
      A8K8Q0

    2. XM_054323241.1 → XP_054179216.1  zinc fingers and homeoboxes protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K8Q0

    3. XM_054323242.1 → XP_054179217.1  zinc fingers and homeoboxes protein 3 isoform X2

      UniProtKB/TrEMBL
      A8K8Q0

    4. XM_054323244.1 → XP_054179219.1  zinc fingers and homeoboxes protein 3 isoform X3

      UniProtKB/TrEMBL
      A8K8Q0

    5. XM_054323233.1 → XP_054179208.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    6. XM_054323234.1 → XP_054179209.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    7. XM_054323236.1 → XP_054179211.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    8. XM_054323232.1 → XP_054179207.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    9. XM_054323237.1 → XP_054179212.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    10. XM_054323235.1 → XP_054179210.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    11. XM_054323238.1 → XP_054179213.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    12. XM_054323239.1 → XP_054179214.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0

    13. XM_054323240.1 → XP_054179215.1  zinc fingers and homeoboxes protein 3 isoform X1

      UniProtKB/TrEMBL
      A8K8Q0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4I2.3 GenPept UniProtKB/Swiss-Prot:Q9H4I2

    Gene LinkOut

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