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Conserved domains on  [gi|768016605|ref|XP_011527006|]
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zinc fingers and homeoboxes protein 3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 105-155 2.95e-22

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


:

Pssm-ID: 465737  Cd Length: 53  Bit Score: 90.47  E-value: 2.95e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768016605  105 KDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSI 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 500-553 6.60e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.49  E-value: 6.60e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768016605 500 KKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLK 553
Cdd:cd00086    6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 621-666 5.25e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.80  E-value: 5.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 768016605   621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 313-363 2.72e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.09  E-value: 2.72e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768016605 313 MDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISW 363
Cdd:cd00086    9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 769-823 7.69e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 7.69e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768016605 769 CKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 823
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homez super family cl13082
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 850-886 4.20e-07

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


The actual alignment was detected with superfamily member pfam11569:

Pssm-ID: 463297  Cd Length: 57  Bit Score: 47.68  E-value: 4.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768016605  850 LQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEK 886
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 105-155 2.95e-22

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 90.47  E-value: 2.95e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768016605  105 KDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSI 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 500-553 6.60e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.49  E-value: 6.60e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768016605 500 KKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLK 553
Cdd:cd00086    6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 497-550 1.24e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 1.24e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 768016605   497 YKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCR 550
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 621-666 5.25e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.80  E-value: 5.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 768016605   621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 621-666 1.30e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 1.30e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 768016605 621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:cd00086    9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 313-363 2.72e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.09  E-value: 2.72e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768016605 313 MDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISW 363
Cdd:cd00086    9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 317-359 3.38e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 3.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 768016605   317 SFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 769-823 7.69e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 7.69e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768016605 769 CKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 823
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 769-820 3.81e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.63  E-value: 3.81e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 768016605   769 CKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALK 820
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 850-886 4.20e-07

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 47.68  E-value: 4.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768016605  850 LQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEK 886
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
Homeodomain pfam00046
Homeodomain;
502-546 5.04e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 5.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 768016605  502 SHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRR 546
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
Homeodomain pfam00046
Homeodomain;
621-666 1.72e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 45.95  E-value: 1.72e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 768016605  621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:pfam00046   9 PEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
Homeodomain pfam00046
Homeodomain;
319-359 5.99e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 5.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768016605  319 LKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 105-155 2.95e-22

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 90.47  E-value: 2.95e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768016605  105 KDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSI 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 500-553 6.60e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.49  E-value: 6.60e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768016605 500 KKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLK 553
Cdd:cd00086    6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 497-550 1.24e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 1.24e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 768016605   497 YKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCR 550
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 621-666 5.25e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.80  E-value: 5.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 768016605   621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 621-666 1.30e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 1.30e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 768016605 621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:cd00086    9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 313-363 2.72e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.09  E-value: 2.72e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768016605 313 MDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISW 363
Cdd:cd00086    9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 317-359 3.38e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 3.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 768016605   317 SFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 769-823 7.69e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 7.69e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768016605 769 CKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 823
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 769-820 3.81e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.63  E-value: 3.81e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 768016605   769 CKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALK 820
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 850-886 4.20e-07

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 47.68  E-value: 4.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768016605  850 LQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEK 886
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
Homeodomain pfam00046
Homeodomain;
502-546 5.04e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 5.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 768016605  502 SHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRR 546
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
Homeodomain pfam00046
Homeodomain;
621-666 1.72e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 45.95  E-value: 1.72e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 768016605  621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:pfam00046   9 PEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
Homeodomain pfam00046
Homeodomain;
319-359 5.99e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 5.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768016605  319 LKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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