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    Alg1 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 208211, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Alg1provided by MGI
    Official Full Name
    ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2384774
    See related
    Ensembl:ENSMUSG00000039427 AllianceGenome:MGI:2384774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HMT1; HMAT1
    Summary
    Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 34.2), ovary adult (RPKM 29.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg1 in Genome Data Viewer
    Location:
    16 A1; 16 2.51 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (5051410..5062773)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5233621..5244909)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Neighboring gene expressed sequence AU021092 Neighboring gene STARR-positive B cell enhancer mm9_chr16:5233472-5233773 Neighboring gene microRNA 6364 Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase Neighboring gene predicted gene 15983 Neighboring gene predicted gene, 57635 Neighboring gene predicted gene, 41414

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18946

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chitobiosyldiphosphodolichol beta-mannosyltransferase
    Names
    GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
    GDP-mannose-dolichol diphosphochitobiose mannosyltransferase
    asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)
    asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
    asparagine-linked glycosylation protein 1 homolog
    beta-1,4 mannosyltransferase
    NP_663337.2
    XP_011244162.1
    XP_036015739.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145362.2 → NP_663337.2  chitobiosyldiphosphodolichol beta-mannosyltransferase

      Status: VALIDATED

      Source sequence(s)
      AK145871, BE948597
      Consensus CDS
      CCDS49753.1
      UniProtKB/Swiss-Prot
      Q3UKT8, Q921Q3
      Related
      ENSMUSP00000097770.3, ENSMUST00000100196.9
      Conserved Domains (2) summary
      cd03816
      Location:33 → 461
      GT1_ALG1_like; This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and ...
      PLN02275
      Location:29 → 424
      PLN02275; transferase, transferring glycosyl groups

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      5051410..5062773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159846.1 → XP_036015739.1  chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1

      Conserved Domains (1) summary
      cd03816
      Location:33 → 515
      GT33_ALG1-like; chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins

    2. XM_011245860.3 → XP_011244162.1  chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X2

      Conserved Domains (1) summary
      cl10013
      Location:24 → 306
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    RNA

    1. XR_004939176.1 RNA Sequence

    2. XR_004939175.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921Q3.3 GenPept UniProtKB/Swiss-Prot:Q921Q3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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