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Conserved domains on  [gi|755553342|ref|XP_011244162|]
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chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X2 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 24-306 4.56e-146

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03816:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 411  Bit Score: 417.44  E-value: 4.56e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  24 RMYEKFFGRLSHLNLCVTNAMREDLA--ENWCVRAVTLYDKPASFFKETPLDLQHELFMKLshtyspfqscsdpshpdte 101
Cdd:cd03816  150 KWYEKTFGRMADAHLCVTKAMQRDLQqfENWNIRATVLYDRPPSHFRPIPLEEKHELFLEL------------------- 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 102 rsaFTERDCQSGVVRRLHGRPALLVSSTSWTEDEDFSILLRALEKFEQQALTGDS-LPSLVCVITGKGPLREHYRHLISQ 180
Cdd:cd03816  211 ---ALFRELAEGAVSYKEGRPALLVSSTSWTPDEDFSILLDALKAYESSAATEPAlLPSLLCIITGKGPLKEMYLELIKE 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 181 KHLQHVRFCTPWLEAEDYPLLLGSADLGVCLHMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFKDAEE 260
Cdd:cd03816  288 LKLKKVTIRTPWLSAEDYPRLLASADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLVFGDSEE 367

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755553342 261 LAAQLQMLFSkfPDPAGKLSQFRKKLQESGQQRWDESWQHTVLPLL 306
Cdd:cd03816  368 LAEQLIDLLS--DFDRGKLNVLKKGAQEESENRWDENWDRVAGPLF 411
 
Name Accession Description Interval E-value
GT33_ALG1-like cd03816
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ...
 24-306 4.56e-146

chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.


Pssm-ID: 340843 [Multi-domain]  Cd Length: 411  Bit Score: 417.44  E-value: 4.56e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  24 RMYEKFFGRLSHLNLCVTNAMREDLA--ENWCVRAVTLYDKPASFFKETPLDLQHELFMKLshtyspfqscsdpshpdte 101
Cdd:cd03816  150 KWYEKTFGRMADAHLCVTKAMQRDLQqfENWNIRATVLYDRPPSHFRPIPLEEKHELFLEL------------------- 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 102 rsaFTERDCQSGVVRRLHGRPALLVSSTSWTEDEDFSILLRALEKFEQQALTGDS-LPSLVCVITGKGPLREHYRHLISQ 180
Cdd:cd03816  211 ---ALFRELAEGAVSYKEGRPALLVSSTSWTPDEDFSILLDALKAYESSAATEPAlLPSLLCIITGKGPLKEMYLELIKE 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 181 KHLQHVRFCTPWLEAEDYPLLLGSADLGVCLHMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFKDAEE 260
Cdd:cd03816  288 LKLKKVTIRTPWLSAEDYPRLLASADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLVFGDSEE 367

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755553342 261 LAAQLQMLFSkfPDPAGKLSQFRKKLQESGQQRWDESWQHTVLPLL 306
Cdd:cd03816  368 LAEQLIDLLS--DFDRGKLNVLKKGAQEESENRWDENWDRVAGPLF 411
PLN02275 PLN02275
transferase, transferring glycosyl groups
 24-269 1.41e-96

transferase, transferring glycosyl groups


Pssm-ID: 215155 [Multi-domain]  Cd Length: 371  Bit Score: 290.42  E-value: 1.41e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  24 RMYEKFFGRLSHLNLCVTNAMREDLAENWCVRAVTLYDKPASFFKETPLdlqhELFMKlshtyspfqscsdpshpdters 103
Cdd:PLN02275 156 RWYERHYGKMADGHLCVTKAMQHELDQNWGIRATVLYDQPPEFFRPASL----EIRLR---------------------- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 104 afterdcqsgvvrrlHGRPALLVSSTSWTEDEDFSILLRALEKFEQ-----------QALTGDSLPSLVCVITGKGPLRE 172
Cdd:PLN02275 210 ---------------PNRPALVVSSTSWTPDEDFGILLEAAVMYDRrvaarlnesdsASGKQSLYPRLLFIITGKGPQKA 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 173 HYRHLISQKHLQHVRFCTPWLEAEDYPLLLGSADLGVCLHMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENG 252
Cdd:PLN02275 275 MYEEKISRLNLRHVAFRTMWLEAEDYPLLLGSADLGVSLHTSSSGLDLPMKVVDMFGCGLPVCAVSYSCIGELVKDGKNG 354

                        250
                 ....*....|....*..
gi 755553342 253 LVFKDAEELAAQLQMLF 269
Cdd:PLN02275 355 LLFSSSSELADQLLELL 371
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 140-265 4.34e-10

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 57.67  E-value: 4.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  140 LLRALEKFEQQaltgdsLPSLVCVITGKGPLREHYRHLISQKHLQ-HVRFcTPWLEAEDYPLLLGSADLGVCLHMSSSgl 218
Cdd:pfam00534  20 LIKAFALLKEK------NPNLKLVIAGDGEEEKRLKKLAEKLGLGdNVIF-LGFVSDEDLPELLKIADVFVLPSRYEG-- 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755553342  219 dLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQL 265
Cdd:pfam00534  91 -FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKpnNAEALAEAI 138
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 201-302 1.65e-09

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 55.00  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 201 LLGSADLGVclhMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQLQMLFSkfpDPAgk 278
Cdd:COG0438   17 LLAAADVFV---LPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAEAILRLLE---DPE-- 88

                         90       100
                 ....*....|....*....|....*.
gi 755553342 279 lsqFRKKLQESGQQRWDE--SWQHTV 302
Cdd:COG0438   89 ---LRRRLGEAARERAEErfSWEAIA 111
 
Name Accession Description Interval E-value
GT33_ALG1-like cd03816
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ...
 24-306 4.56e-146

chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.


Pssm-ID: 340843 [Multi-domain]  Cd Length: 411  Bit Score: 417.44  E-value: 4.56e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  24 RMYEKFFGRLSHLNLCVTNAMREDLA--ENWCVRAVTLYDKPASFFKETPLDLQHELFMKLshtyspfqscsdpshpdte 101
Cdd:cd03816  150 KWYEKTFGRMADAHLCVTKAMQRDLQqfENWNIRATVLYDRPPSHFRPIPLEEKHELFLEL------------------- 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 102 rsaFTERDCQSGVVRRLHGRPALLVSSTSWTEDEDFSILLRALEKFEQQALTGDS-LPSLVCVITGKGPLREHYRHLISQ 180
Cdd:cd03816  211 ---ALFRELAEGAVSYKEGRPALLVSSTSWTPDEDFSILLDALKAYESSAATEPAlLPSLLCIITGKGPLKEMYLELIKE 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 181 KHLQHVRFCTPWLEAEDYPLLLGSADLGVCLHMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFKDAEE 260
Cdd:cd03816  288 LKLKKVTIRTPWLSAEDYPRLLASADLGVCLHTSSSGLDLPMKVVDMFGCGLPVCAMDFKCIGELVKHGVNGLVFGDSEE 367

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755553342 261 LAAQLQMLFSkfPDPAGKLSQFRKKLQESGQQRWDESWQHTVLPLL 306
Cdd:cd03816  368 LAEQLIDLLS--DFDRGKLNVLKKGAQEESENRWDENWDRVAGPLF 411
PLN02275 PLN02275
transferase, transferring glycosyl groups
 24-269 1.41e-96

transferase, transferring glycosyl groups


Pssm-ID: 215155 [Multi-domain]  Cd Length: 371  Bit Score: 290.42  E-value: 1.41e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  24 RMYEKFFGRLSHLNLCVTNAMREDLAENWCVRAVTLYDKPASFFKETPLdlqhELFMKlshtyspfqscsdpshpdters 103
Cdd:PLN02275 156 RWYERHYGKMADGHLCVTKAMQHELDQNWGIRATVLYDQPPEFFRPASL----EIRLR---------------------- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 104 afterdcqsgvvrrlHGRPALLVSSTSWTEDEDFSILLRALEKFEQ-----------QALTGDSLPSLVCVITGKGPLRE 172
Cdd:PLN02275 210 ---------------PNRPALVVSSTSWTPDEDFGILLEAAVMYDRrvaarlnesdsASGKQSLYPRLLFIITGKGPQKA 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 173 HYRHLISQKHLQHVRFCTPWLEAEDYPLLLGSADLGVCLHMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENG 252
Cdd:PLN02275 275 MYEEKISRLNLRHVAFRTMWLEAEDYPLLLGSADLGVSLHTSSSGLDLPMKVVDMFGCGLPVCAVSYSCIGELVKDGKNG 354

                        250
                 ....*....|....*..
gi 755553342 253 LVFKDAEELAAQLQMLF 269
Cdd:PLN02275 355 LLFSSSSELADQLLELL 371
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 115-307 1.80e-12

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 67.18  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 115 VRRLHGRPA---LLVSSTSWTEDEDFSILLRALekfeqqALTGDSLPSLVCVITGK-GPLREHYRHLISqKHLQHVRFcT 190
Cdd:cd03801  182 LRRKLGIPPdrpVLLFVGRLSPRKGVDLLLEAL------AKLLRRGPDVRLVIVGGdGPLRAELEELEL-GLGDRVRF-L 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 191 PWLEAEDYPLLLGSADLGVclhMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVF--KDAEELAAQLQML 268
Cdd:cd03801  254 GFVPDEELPALYAAADVFV---LPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVppDDVEALADALLRL 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755553342 269 FSkfpDPAgklsqFRKKLQESGQQRWDE--SWQHTVLPLLA 307
Cdd:cd03801  331 LA---DPE-----LRARLGRAARERVAErfSWERVAERLLD 363
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 140-265 4.34e-10

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 57.67  E-value: 4.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  140 LLRALEKFEQQaltgdsLPSLVCVITGKGPLREHYRHLISQKHLQ-HVRFcTPWLEAEDYPLLLGSADLGVCLHMSSSgl 218
Cdd:pfam00534  20 LIKAFALLKEK------NPNLKLVIAGDGEEEKRLKKLAEKLGLGdNVIF-LGFVSDEDLPELLKIADVFVLPSRYEG-- 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755553342  219 dLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQL 265
Cdd:pfam00534  91 -FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKpnNAEALAEAI 138
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 98-255 8.25e-10

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 58.18  E-value: 8.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  98 PDTERSAFTERDCQSGVVRRLHGRPALLVSStsWTEDEDFSILLRALEKFEQQaltgdsLPSLVCVITGKGPLREHYRHL 177
Cdd:cd01635   88 PDSLESTRSELLALARLLVSLPLADKVSVGR--LVPEKGIDLLLEALALLKAR------LPDLVLVLVGGGGEREEEEAL 159

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755553342 178 ISQ-KHLQHVRFCTPWLEAEDYPLLLGSADLGVclhMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVF 255
Cdd:cd01635  160 AAAlGLLERVVIIGGLVDDEVLELLLAAADVFV---LPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 201-302 1.65e-09

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 55.00  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 201 LLGSADLGVclhMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQLQMLFSkfpDPAgk 278
Cdd:COG0438   17 LLAAADVFV---LPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAEAILRLLE---DPE-- 88

                         90       100
                 ....*....|....*....|....*.
gi 755553342 279 lsqFRKKLQESGQQRWDE--SWQHTV 302
Cdd:COG0438   89 ---LRRRLGEAARERAEErfSWEAIA 111
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 136-292 2.28e-09

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 57.75  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 136 DFSILLRALEKFEqqaltgDSLPSLVCVITGKGPLREHYRHLISQKHLQ-HVRFCT------PWLEAedyplllgsADLG 208
Cdd:cd03811  202 GHDLLIEAFAKLR------KKYPDVKLVILGDGPLREELEKLAKELGLAeRVIFLGfqsnpyPYLKK---------ADLF 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 209 VclhMSSS--GLdlPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQLQMLFSKFPDPAgKLSQFRK 284
Cdd:cd03811  267 V---LSSRyeGF--PNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPdgDAAALAGILAALLQKKLDAA-LRERLAK 340


                 ....*...
gi 755553342 285 KLQESGQQ 292
Cdd:cd03811  341 AQEAVFRE 348
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 137-270 1.12e-07

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 52.62  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 137 FSILLRALEKFEQQaltgdsLPSLVCVITGKGPLREHYRHLISQKHLQH-VRFCTPWLEAEDYpllLGSADLGVclhMSS 215
Cdd:cd03820  196 FDLLIEAWALIAKK------HPDWKLRIYGDGPEREELEKLIDKLGLEDrVKLLGPTKNIAEE---YANSSIFV---LSS 263

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755553342 216 S--GLdlPMKVVDMFGCHLPVcaVNFKCLH---ELVRHGENGLVFK--DAEELAAQLQMLFS 270
Cdd:cd03820  264 RyeGF--PMVLLEAMAYGLPI--ISFDCPTgpsEIIEDGENGLLVPngDVDALAEALLRLME 321
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 137-263 8.16e-07

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 49.97  E-value: 8.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 137 FSILLRALEKFeqqaltgDSLPSLVCVITGKGPLREHYRHLISQKHL-QHVRFcTPWLEAEDYPLLLGSADLGVclhmSS 215
Cdd:cd03817  216 IDFLLRAFAEL-------KKEPNIKLVIVGDGPEREELKELARELGLaDKVIF-TGFVPREELPEYYKAADLFV----FA 283

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755553342 216 SgldlpmkVVDMFG--------CHLPVCAVNFKCLHELVRHGENGLVFKDAEELAA 263
Cdd:cd03817  284 S-------TTETQGlvyleamaAGLPVVAAKDPAASELVEDGENGFLFEPNDETLA 332
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 135-268 8.50e-07

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 50.03  E-value: 8.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 135 EDFSILLRALEKFEQQaltgdslPSLVCVITGKGPLREHYRHLISQKHLQHVRFcTPWLEAEDYPLLLGSADLG-VCLHM 213
Cdd:cd03794  230 QGLETLLEAAERLKRR-------PDIRFLFVGDGDEKERLKELAKARGLDNVTF-LGRVPKEEVPELLSAADVGlVPLKD 301

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755553342 214 S-SSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQLQML 268
Cdd:cd03794  302 NpANRGSSPSKLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEpgDPEALADAILEL 359
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 113-293 3.24e-06

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 48.08  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 113 GVVRRLHgrpallvsstswtEDEDFSILLRALekfeqqALTGDSLPSLVCVITGKGPLREHYRHLISQKHLQ-HVRFCTp 191
Cdd:cd03807  194 GIVGRLH-------------PVKDHSDLLRAA------ALLVETHPDLRLLLVGRGPERPNLERLLLELGLEdRVHLLG- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 192 wlEAEDYPLLLGSADLGVclhMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLV-FKDAEELAAQLQMLFS 270
Cdd:cd03807  254 --ERSDVPALLPAMDIFV---LSSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDGTGFLVpAGDPQALADAIRALLE 328

                        170       180
                 ....*....|....*....|...
gi 755553342 271 kfpDPAGklsqfRKKLQESGQQR 293
Cdd:cd03807  329 ---DPEK-----RARLGRAARER 343
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 140-263 2.30e-04

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 42.34  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342 140 LLRALEKFeqqaltgDSLPSLVCVITGKGPLREHYRHLISQKHLQH-VRFCTPwleAEDYPLLLGSADLGVclhMSSSGL 218
Cdd:cd03819  200 LVDAAAEL-------KDEPDFRLLVAGDGPERDEIRRLVERLGLRDrVTFTGF---REDVPAALAASDVVV---LPSLHE 266

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755553342 219 DLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAA 263
Cdd:cd03819  267 EFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPpgDAEALAD 313
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 221-268 4.77e-04

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 41.55  E-value: 4.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 755553342 221 PMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFK--DAEELAAQLQML 268
Cdd:cd03823  275 GLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFApgDAEDLAAAMRRL 324
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
209-307 6.97e-03

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 35.27  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553342  209 VCLHMSSSGLDLPMKVVDMFGCHLPVCAVNFKCLHELVRHGENGLVFKDAEELAAQLQMLFSkfpDPAgklsqFRKKLQE 288
Cdd:pfam13524   1 IVLNPSRRPDSPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLE---HPE-----ERRAIAA 72

                          90       100
                  ....*....|....*....|.
gi 755553342  289 SGQQR-WDE-SWQHTVLPLLA 307
Cdd:pfam13524  73 AGRERvLAEhTYAHRAEQLLD 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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