U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    PCID2 PCI domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 55795, updated on 10-Dec-2024

    Summary

    Official Symbol
    PCID2provided by HGNC
    Official Full Name
    PCI domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25653
    See related
    Ensembl:ENSG00000126226 MIM:613713; AllianceGenome:HGNC:25653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F10
    Summary
    This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in testis (RPKM 6.6), ovary (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PCID2 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113165002..113208669, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112427103..112461015, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113831850..113862983, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5538 Neighboring gene uncharacterized LOC124903216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113812445-113813022 Neighboring gene F10 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113813599-113814176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113825981-113826504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113827099-113827599 Neighboring gene protein Z, vitamin K dependent plasma glycoprotein Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113841395-113842594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113862038-113862688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113862689-113863338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113874723-113875286 Neighboring gene cullin 4A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113876707-113877556 Neighboring gene microRNA 8075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113928297-113928796 Neighboring gene Sharpr-MPRA regulatory region 2925 Neighboring gene lactate dehydrogenase B pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ11305, FLJ39706, FLJ99362, MGC16774, DKFZp686C20226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding  
    enables double-stranded DNA binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin organization  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
    involved_in negative regulation of lymphoid progenitor cell differentiation  
    involved_in negative regulation of transcription initiation by RNA polymerase II  
    involved_in poly(A)+ mRNA export from nucleus  
    involved_in positive regulation of B cell differentiation  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery  
    involved_in protein transport  
    involved_in regulation of mRNA stability PubMed 
    involved_in spleen development  
    involved_in transcription elongation by RNA polymerase II  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    part_of nuclear pore nuclear basket PubMed 
    located_in nucleus PubMed 
    part_of transcription export complex 2  
    part_of transcription export complex 2 PubMed 

    General protein information

    Preferred Names
    PCI domain-containing protein 2
    Names
    CSN12-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127202.4 → NP_001120674.1  PCI domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001120674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AA779868, AI272719, AK001185, AL137002
      Consensus CDS
      CCDS9532.2
      UniProtKB/Swiss-Prot
      A6NK09, Q3ZCX1, Q5JVF3, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6, Q9NVY1, Q9NW44, Q9NWH3
      UniProtKB/TrEMBL
      A8K097
      Related
      ENSP00000337405.4, ENST00000337344.9
      Conserved Domains (1) summary
      cl02111
      Location:80 → 393
      PCI; PCI domain
    2. NM_001127203.4 → NP_001120675.1  PCI domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001120675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 3' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AA779868, AI272719, AL137002, BC016614, HY174088
      Consensus CDS
      CCDS9532.2
      UniProtKB/Swiss-Prot
      A6NK09, Q3ZCX1, Q5JVF3, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6, Q9NVY1, Q9NW44, Q9NWH3
      UniProtKB/TrEMBL
      A8K097
      Related
      ENSP00000364626.1, ENST00000375477.5
      Conserved Domains (1) summary
      cl02111
      Location:80 → 393
      PCI; PCI domain
    3. NM_001258213.3 → NP_001245142.1  PCI domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001245142.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (3) has a shorter, distinct N-terminus compared to isoform 1. Variants 5 and 6 encode the same isoform (3).
      Source sequence(s)
      AA779868, AI272719, AL136221, AL137002, BC031246, BM932149, DA058550
      Consensus CDS
      CCDS58301.1
      UniProtKB/TrEMBL
      A8K097
      Related
      ENSP00000364606.2, ENST00000375457.2
      Conserved Domains (1) summary
      cl02111
      Location:78 → 391
      PCI; PCI domain
    4. NM_001320655.2 → NP_001307584.1  PCI domain-containing protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (3) has a shorter, distinct N-terminus compared to isoform 1. Variants 5 and 6 encode the same isoform (3).
      Source sequence(s)
      AA779868, AI272719, AK098706, AL136221, AL137002, BC031246, BM932149, DA058550
      Consensus CDS
      CCDS58301.1
      UniProtKB/TrEMBL
      A8K097
      Related
      ENSP00000364608.1, ENST00000375459.5
      Conserved Domains (1) summary
      cl02111
      Location:78 → 391
      PCI; PCI domain
    5. NM_001320656.2 → NP_001307585.1  PCI domain-containing protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses two alternate splice sites, but maintains the reading frame, and lacks a segment in the 3' UTR, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AA779868, AI272719, AK002167, AL137002, BC016614, BC031246
      Consensus CDS
      CCDS58302.1
      UniProtKB/TrEMBL
      A8K097
      Related
      ENSP00000246505.5, ENST00000246505.9
      Conserved Domains (1) summary
      cl02111
      Location:190 → 447
      PCI; PCI domain
    6. NM_001320657.2 → NP_001307586.1  PCI domain-containing protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a longer, distinct C-terminus than isoform 1.
      Source sequence(s)
      AA779868, AI272719, AK001185, AK002167, AL137002, AL546858, BI763234
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:80 → 368
      PCI; PCI domain
    7. NM_001320659.2 → NP_001307588.1  PCI domain-containing protein 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site and lacks a segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (5) has a longer, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL136221, AL137002
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:80 → 368
      PCI; PCI domain
    8. NM_001320660.2 → NP_001307589.1  PCI domain-containing protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (6) has distinct N- and C-termini and is longer than isoform 1.
      Source sequence(s)
      AA779868, AI272719, AK001185, AL136221, AL137002, BC031246, BI763234, BM932149, DA058550
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:78 → 366
      PCI; PCI domain
    9. NM_001353091.2 → NP_001340020.1  PCI domain-containing protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL136221, AL137002
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:38 → 351
      PCI; PCI domain
    10. NM_001353092.2 → NP_001340021.1  PCI domain-containing protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL136221, AL137002
      Consensus CDS
      CCDS58301.1
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:78 → 391
      PCI; PCI domain
    11. NM_001353093.2 → NP_001340022.1  PCI domain-containing protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL136221, AL137002
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:38 → 351
      PCI; PCI domain
    12. NM_001353094.2 → NP_001340023.1  PCI domain-containing protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL136221, AL137002
      UniProtKB/TrEMBL
      A8K097
      Conserved Domains (1) summary
      cl02111
      Location:38 → 351
      PCI; PCI domain
    13. NM_001353095.2 → NP_001340024.1  PCI domain-containing protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL136221, AL137002
      Conserved Domains (1) summary
      cl02111
      Location:2 → 226
      PCI; PCI domain
    14. NM_018386.5 → NP_060856.2  PCI domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_060856.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 3' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AA779868, AI272719, AK023313, AL137002, HY174088
      Consensus CDS
      CCDS9532.2
      UniProtKB/Swiss-Prot
      A6NK09, Q3ZCX1, Q5JVF3, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6, Q9NVY1, Q9NW44, Q9NWH3
      UniProtKB/TrEMBL
      A8K097
      Related
      ENSP00000364628.2, ENST00000375479.6
      Conserved Domains (1) summary
      cl02111
      Location:80 → 393
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      113165002..113208669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430477.1 → XP_047286433.1  PCI domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K097
    2. XM_047430478.1 → XP_047286434.1  PCI domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K097
    3. XM_047430479.1 → XP_047286435.1  PCI domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A8K097
    4. XM_047430480.1 → XP_047286436.1  PCI domain-containing protein 2 isoform X4

    5. XM_005268325.5 → XP_005268382.1  PCI domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      cl02111
      Location:80 → 228
      PCI; PCI domain
    6. XM_047430481.1 → XP_047286437.1  PCI domain-containing protein 2 isoform X6

    RNA

    1. XR_001749631.2 RNA Sequence

    2. XR_007063692.1 RNA Sequence

    3. XR_007063691.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      112427103..112461015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374745.1 → XP_054230720.1  PCI domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A8K097
    2. XM_054374744.1 → XP_054230719.1  PCI domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K097
    3. XM_054374746.1 → XP_054230721.1  PCI domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K097
    4. XM_054374747.1 → XP_054230722.1  PCI domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A8K097
    5. XM_054374748.1 → XP_054230723.1  PCI domain-containing protein 2 isoform X5

    6. XM_054374749.1 → XP_054230724.1  PCI domain-containing protein 2 isoform X6

    External link. Please review our privacy policy.