CETN1 centrin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CETN1provided by HGNC
Official Full Name: centrin 1provided by HGNC
Primary source: HGNC:HGNC:1866
See related: Ensembl:ENSG00000177143 MIM:603187; AllianceGenome:HGNC:1866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CEN1; CETN
Summary: The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
Orthologs: mouse all
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Genomic context

Location:: 18p11.32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (580380..582114)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (734775..736509)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (580380..582114)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.
Title: Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.
Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.
Title: Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.
Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1.
Title: Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1.
important spectral and hydrodynamic characteristics of human Centrin-1, accounting that HsCentrin-1 has moderate affinity for Ca(2+). Centrin-1 does not gain structure as seen by far- and near-UV circular dichroism, rather there is a loss of ellipticity, though inconsiderable upon binding Ca(2+).
Title: Optimization of purification method and characterization of recombinant human Centrin-1.
A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.
Title: A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.
CETN1 is overexpressed in breast cancer tissue and promotes cells'proliferation, tumor growth and metastasis.
Title: Knockdown of CETN1 inhibits breast cancer cells proliferation.
These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis.
Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH35650 (e-PCR)
- UniSTS:90192

CETN1_4560 (e-PCR)
- UniSTS:462810

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor connecting cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: centrin-1

Names: EF-hand protein; calcium binding protein; caltractin; centrin, EF-hand protein, 1; testicular tissue protein Li 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.