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    Hspa8 heat shock protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 15481, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hspa8provided by MGI
    Official Full Name
    heat shock protein 8provided by MGI
    Primary source
    MGI:MGI:105384
    See related
    Ensembl:ENSMUSG00000015656 AllianceGenome:MGI:105384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; 2410008N15Rik
    Summary
    Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including clathrin coat disassembly; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within chaperone cofactor-dependent protein refolding; positive regulation of mRNA splicing, via spliceosome; and regulation of cell cycle. Located in several cellular components, including extracellular exosome; late endosome; and perinuclear region of cytoplasm. Is active in several cellular components, including glycinergic synapse; photoreceptor ribbon synapse; and postsynaptic specialization membrane. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 956.1), CNS E11.5 (RPKM 802.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hspa8 in Genome Data Viewer
    Location:
    9 A5.1; 9 21.55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40712572..40716498)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40801276..40805202)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CXADR-like membrane protein Neighboring gene predicted gene, 48293 Neighboring gene STARR-seq mESC enhancer starr_23871 Neighboring gene STARR-seq mESC enhancer starr_23872 Neighboring gene predicted gene 16096 Neighboring gene STARR-positive B cell enhancer ABC_E8284 Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene STARR-seq mESC enhancer starr_23873 Neighboring gene brain specific homeobox Neighboring gene junctional cadherin complex regulator Neighboring gene ubiquitin specific peptidase 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC102007, MGC106514, MGC118485

    Gene Ontology Provided by MGI

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables A1 adenosine receptor binding  
    enables A1 adenosine receptor binding  
    enables ADP binding  
    enables ADP binding  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity PubMed 
    enables ATP hydrolysis activity  
    enables ATP-dependent protein disaggregase activity  
    enables ATP-dependent protein folding chaperone  
    enables C3HC4-type RING finger domain binding  
    enables G protein-coupled receptor binding  
    enables RNA binding  
    enables RNA binding  
    enables clathrin-uncoating ATPase activity  
    enables clathrin-uncoating ATPase activity  
    enables enzyme binding  
    enables enzyme binding  
    enables heat shock protein binding  
    enables heat shock protein binding  
    enables peptide binding  
    enables peptide binding  
    enables phosphatidylserine binding PubMed 
    enables prostaglandin binding  
    enables prostaglandin binding  
    enables protein binding PubMed 
    enables protein folding chaperone  
    enables protein-folding chaperone binding  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables signaling receptor binding  
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding PubMed 
    enables unfolded protein binding  
    Items 1 - 25 of 35
    Items 1 - 25 of 61
    Process Evidence Code Pubs
    involved_in ATP metabolic process  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in cellular response to cadmium ion  
    involved_in cellular response to heat  
    involved_in cellular response to hydrogen peroxide  
    involved_in cerebellum development  
    involved_in chaperone cofactor-dependent protein refolding  
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding PubMed 
    acts_upstream_of_or_within chaperone-mediated autophagy  
    involved_in chaperone-mediated autophagy  
    involved_in chaperone-mediated autophagy translocation complex disassembly  
    involved_in chaperone-mediated protein folding PubMed 
    involved_in chaperone-mediated protein folding PubMed 
    involved_in chaperone-mediated protein folding PubMed 
    involved_in clathrin coat disassembly  
    involved_in clathrin coat disassembly PubMed 
    acts_upstream_of_or_within clathrin coat disassembly PubMed 
    involved_in clathrin coat disassembly  
    involved_in estrous cycle  
    involved_in forebrain development  
    involved_in kidney development  
    involved_in late endosomal microautophagy PubMed 
    involved_in mRNA splicing, via spliceosome PubMed 
    involved_in maintenance of postsynaptic specialization structure  
    involved_in modulation by host of viral process PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of NLRP3 inflammasome complex assembly  
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of supramolecular fiber organization  
    involved_in positive regulation by host of viral genome replication PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity  
    involved_in positive regulation of lysosomal membrane permeability  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome PubMed 
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of protein refolding  
    involved_in positive regulation of proteolysis  
    acts_upstream_of_or_within protein folding PubMed 
    involved_in protein import into nucleus  
    involved_in protein refolding  
    involved_in protein refolding  
    involved_in protein refolding  
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy  
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy  
    involved_in protein transmembrane import into intracellular organelle  
    acts_upstream_of_or_within protein-containing complex disassembly  
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    involved_in regulation of postsynapse organization PubMed 
    involved_in regulation of postsynapse organization PubMed 
    involved_in regulation of protein complex stability  
    involved_in regulation of protein stability  
    involved_in response to activity  
    involved_in response to estradiol  
    involved_in response to ethanol  
    involved_in response to nickel cation  
    involved_in response to odorant  
    involved_in response to progesterone  
    involved_in response to starvation  
    involved_in response to xenobiotic stimulus  
    involved_in skeletal muscle tissue development  
    involved_in slow axonal transport  
    Items 1 - 25 of 61
    Items 1 - 20 of 74
    Component Evidence Code Pubs
    part_of Prp19 complex  
    part_of Prp19 complex  
    located_in asymmetric synapse  
    located_in autophagosome  
    located_in autophagosome  
    located_in axon  
    located_in cell surface  
    located_in cell surface  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    located_in dendritic shaft  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in dendritic spine  
    located_in extracellular exosome PubMed 
    located_in extracellular exosome  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in glycinergic synapse PubMed 
    is_active_in glycinergic synapse  
    located_in intermediate filament  
    located_in intermediate filament  
    located_in intracellular anatomical structure PubMed 
    located_in late endosome PubMed 
    located_in late endosome lumen  
    located_in lysosomal matrix  
    is_active_in lysosomal membrane  
    located_in lysosomal membrane  
    is_active_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in melanosome  
    located_in microtubule  
    located_in microtubule  
    located_in myelin sheath PubMed 
    located_in neuron spine  
    located_in neuronal cell body  
    located_in nucleolus  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    located_in photoreceptor inner segment  
    located_in photoreceptor inner segment  
    is_active_in photoreceptor ribbon synapse PubMed 
    is_active_in plasma membrane  
    is_active_in postsynapse  
    located_in postsynaptic cytosol  
    located_in postsynaptic density  
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic specialization membrane PubMed 
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    is_active_in presynapse  
    located_in presynaptic cytosol  
    part_of protein folding chaperone complex  
    part_of protein-containing complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    part_of spliceosomal complex  
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    located_in terminal bouton  
    located_in terminal bouton  
    Items 1 - 20 of 74

    General protein information

    Preferred Names
    heat shock cognate 71 kDa protein
    Names
    heat shock 70 kDa protein 8
    heat shock cognate hsc73
    heat shock protein cognate 70
    NP_001351409.1
    NP_112442.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364480.1NP_001351409.1  heat shock cognate 71 kDa protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158355
      Consensus CDS
      CCDS90540.1
      UniProtKB/TrEMBL
      Q3TEK2, Q3TF16, Q3TH56, Q3TQ13, Q3UBA6, Q504P4
      Related
      ENSMUSP00000113722.2, ENSMUST00000117557.8
      Conserved Domains (1) summary
      cl26953
      Location:1594
      HSP70; Hsp70 protein
    2. NM_031165.5NP_112442.2  heat shock cognate 71 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_112442.2

      Status: VALIDATED

      Source sequence(s)
      AK151775, CD774246
      Consensus CDS
      CCDS23083.1
      UniProtKB/Swiss-Prot
      P08109, P12225, P63017, Q3U6R0, Q3U764, Q3U7D7, Q3U7E2, Q3U9B4, Q3U9G0, Q3UGM0, Q5FWJ6, Q62373, Q62374, Q62375, Q6NZD0
      UniProtKB/TrEMBL
      Q3TF16, Q3TH56, Q3TQ13, Q3UBA6
      Related
      ENSMUSP00000015800.10, ENSMUST00000015800.16
      Conserved Domains (1) summary
      PTZ00009
      Location:1613
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      40712572..40716498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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