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    PLCG2 phospholipase C gamma 2 [ Homo sapiens (human) ]

    Gene ID: 5336, updated on 4-Jan-2025

    Summary

    Official Symbol
    PLCG2provided by HGNC
    Official Full Name
    phospholipase C gamma 2provided by HGNC
    Primary source
    HGNC:HGNC:9066
    See related
    Ensembl:ENSG00000197943 MIM:600220; AllianceGenome:HGNC:9066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCAS3; APLAID; PLC-IV; PLC-gamma-2
    Summary
    The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
    Expression
    Broad expression in lymph node (RPKM 20.0), spleen (RPKM 12.3) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PLCG2 in Genome Data Viewer
    Location:
    16q23.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (81739041..81962685)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (87801375..88026424)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (81772646..81996290)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene c-Maf inducing protein Neighboring gene uncharacterized LOC105371362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81666826-81667665 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81667666-81668506 Neighboring gene Sharpr-MPRA regulatory region 7704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81678346-81679052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81686310-81687034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81687035-81687760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81695233-81696130 Neighboring gene uncharacterized LOC100129617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81716567-81717362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81719349-81720088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81720089-81720826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81724705-81725344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:81738285-81738786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81745144-81745826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81746509-81747190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81747191-81747871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11197 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81750745-81750968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11198 Neighboring gene Sharpr-MPRA regulatory region 4528 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81758203-81758451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:81770025-81770957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81772148-81772930 Neighboring gene uncharacterized LOC105369213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81779157-81779776 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81780739-81780931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81785671-81786279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81786280-81786887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11204 Neighboring gene Sharpr-MPRA regulatory region 4151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7761 Neighboring gene Sharpr-MPRA regulatory region 14941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11220 Neighboring gene uncharacterized LOC124903731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81864849-81865430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81865431-81866012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81933783-81934284 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:81946417-81946916 Neighboring gene NANOG hESC enhancer GRCh37_chr16:82009174-82009740 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:82011207-82011762 Neighboring gene RN7SK pseudogene 176 Neighboring gene uncharacterized LOC112268169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11226 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene HSD17B2 antisense RNA 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (16 hits/1275 screens)

    Associated conditions

    EBI GWAS Catalog

    Description
    Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    Pr55(Gag) gag SPRY2 interactions with PI(4,5)P2 and PLCgamma allow it to influence HIV-1 Gag release through interference with PI(4,5)P2 dynamics PubMed
    gag Phospholipase C-gamma is required for HIV-1 Gag release in the presence or absence of TSG101 binding PubMed
    Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
    tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 65
    Process Evidence Code Pubs
    involved_in B cell activation PubMed 
    involved_in B cell differentiation  
    involved_in B cell receptor signaling pathway PubMed 
    involved_in B cell receptor signaling pathway PubMed 
    involved_in B cell receptor signaling pathway  
    involved_in B cell receptor signaling pathway PubMed 
    involved_in Fc-epsilon receptor signaling pathway  
    involved_in T cell receptor signaling pathway  
    involved_in Wnt signaling pathway PubMed 
    involved_in antifungal innate immune response  
    involved_in calcium-mediated signaling PubMed 
    involved_in calcium-mediated signaling PubMed 
    involved_in cell activation  
    involved_in cellular response to calcium ion PubMed 
    involved_in cellular response to lectin  
    involved_in cellular response to lipid PubMed 
    involved_in follicular B cell differentiation  
    involved_in inositol trisphosphate biosynthetic process  
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction  
    involved_in lipopolysaccharide-mediated signaling pathway PubMed 
    involved_in macrophage activation involved in immune response  
    involved_in negative regulation of programmed cell death  
    involved_in phosphatidylinositol biosynthetic process PubMed 
    involved_in phosphatidylinositol metabolic process  
    involved_in phosphatidylinositol-mediated signaling  
    involved_in phospholipid catabolic process  
    involved_in platelet activation  
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of I-kappaB phosphorylation  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    acts_upstream_of_or_within positive regulation of NLRP3 inflammasome complex assembly PubMed 
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling  
    involved_in positive regulation of cell cycle G1/S phase transition  
    involved_in positive regulation of dendritic cell cytokine production  
    involved_in positive regulation of epithelial cell migration  
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of positive regulation of gene expression  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-2 production  
    involved_in positive regulation of interleukin-23 production  
    involved_in positive regulation of interleukin-6 production  
    acts_upstream_of positive regulation of macrophage cytokine production  
    involved_in positive regulation of neuroinflammatory response PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of phagocytosis, engulfment PubMed 
    acts_upstream_of positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of receptor internalization  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type I interferon production  
    involved_in programmed cell death  
    acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade  
    involved_in regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of regulation of lipid metabolic process PubMed 
    involved_in release of sequestered calcium ion into cytosol  
    involved_in release of sequestered calcium ion into cytosol PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to yeast  
    involved_in stimulatory C-type lectin receptor signaling pathway  
    involved_in stimulatory C-type lectin receptor signaling pathway  
    involved_in toll-like receptor signaling pathway  
    Items 1 - 25 of 65
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in extracellular exosome PubMed 
    located_in intracellular vesicle PubMed 
    located_in membrane raft  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in ruffle membrane  
    is_active_in ruffle membrane PubMed 

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    Names
    phosphoinositide phospholipase C-gamma-2
    phospholipase C, gamma 2 (phosphatidylinositol-specific)
    phospholipase C-IV
    NP_001412678.1
    NP_001412679.1
    NP_001412680.1
    NP_002652.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032019.2 RefSeqGene

      Range
      45162..226198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_376

    mRNA and Protein(s)

    1. NM_001425749.1 → NP_001412678.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

      Status: REVIEWED

      Source sequence(s)
      AC092142, AC098966, AC099524
      UniProtKB/Swiss-Prot
      D3DUL3, P16885, Q3ZTS2, Q59H45, Q969T5
      UniProtKB/TrEMBL
      A0A8V8TMG4
      Related
      ENSP00000520638.1, ENST00000565054.7
    2. NM_001425750.1 → NP_001412679.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

      Status: REVIEWED

      Source sequence(s)
      AC092142, AC098966, AC099524
      UniProtKB/Swiss-Prot
      D3DUL3, P16885, Q3ZTS2, Q59H45, Q969T5
      UniProtKB/TrEMBL
      A0A8V8TMG4
      Related
      ENSP00000520637.1, ENST00000697580.2
    3. NM_001425751.1 → NP_001412680.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

      Status: REVIEWED

      Source sequence(s)
      AC092142, AC098966, AC099524
      UniProtKB/Swiss-Prot
      D3DUL3, P16885, Q3ZTS2, Q59H45, Q969T5
      UniProtKB/TrEMBL
      A0A8V8TMG4
    4. NM_002661.5 → NP_002652.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

      See identical proteins and their annotated locations for NP_002652.2

      Status: REVIEWED

      Source sequence(s)
      AB208914, AC092142, BC007565, BP351485, BX504887, DB456860
      Consensus CDS
      CCDS42204.1
      UniProtKB/Swiss-Prot
      D3DUL3, P16885, Q3ZTS2, Q59H45, Q969T5
      UniProtKB/TrEMBL
      A0A8V8TMG4
      Related
      ENSP00000482457.1, ENST00000564138.6
      Conserved Domains (9) summary
      cd00275
      Location:1061 → 1187
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:311 → 458
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:641 → 744
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:527 → 627
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11969
      Location:773 → 827
      SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
      cd13234
      Location:840 → 910
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd13362
      Location:22 → 140
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      cl14615
      Location:926 → 1031
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:475 → 510
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      81739041..81962685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      87801375..88026424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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