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DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [ Homo sapiens (human) ]

Gene ID: 27071, updated on 27-Nov-2024

Summary

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Official Symbol
DAPP1provided by HGNC
Official Full Name
dual adaptor of phosphotyrosine and 3-phosphoinositides 1provided by HGNC
Primary source
HGNC:HGNC:16500
See related
Ensembl:ENSG00000070190 MIM:605768; AllianceGenome:HGNC:16500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAM32
Summary
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lymph node (RPKM 16.8), appendix (RPKM 14.4) and 15 other tissues See more
Orthologs
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Genomic context

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See DAPP1 in Genome Data Viewer
Location:
4q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (99816827..99872333)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (103132302..103187798)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100737984..100791347)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:100484300-100485499 Neighboring gene microsomal triglyceride transfer protein Neighboring gene chromosome 4 open reading frame 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15583 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival. Niiro H, et al. J Exp Med, 2002 Jan 7. PMID 11781373, Free PMC Article
  2. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Ferguson KM, et al. Mol Cell, 2000 Aug. PMID 10983984
  3. The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. Niiro H, et al. J Immunol, 2004 Nov 1. PMID 15494510
  4. The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation. Ortner D, et al. J Immunol, 2011 Oct 15. PMID 21930970
  5. DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Dowler S, et al. Biochem J, 1999 Aug 15. PMID 10432293, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we propose a role for Bam32 in the signaling of MHC class I molecules in professional Ag-presenting DC for the regulation of CD8(+) T cell activation.
    Title: The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.
  2. BAM32 works downstream of Src family protein tyrosine kinases and functions to link B cell antigen receptor signals with antigen-processing pathways in B cells.
    Title: The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.
  3. novel phosphorylation-dependent function of Bam32 in regulating Rac1 activation and actin remodeling.
    Title: The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp667E0716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Names
B-cell adapter molecule of 32 kDa
b lymphocyte adapter protein Bam32
hDAPP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306151.2 → NP_001293080.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 2

    See identical proteins and their annotated locations for NP_001293080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate exon that causes a frameshift in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter and has a novel C-terminus compared to isoform 1.
    Source sequence(s)
    AF186022, AP001962, BC012924, CA428013
    Consensus CDS
    CCDS77945.1
    UniProtKB/TrEMBL
    J3KNB3
    Related
    ENSP00000296414.7, ENST00000296414.11
    Conserved Domains (2) summary
    cd10355
    Location:28 → 119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    cd10573
    Location:163 → 258
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain

  2. NM_014395.3 → NP_055210.2  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1

    See identical proteins and their annotated locations for NP_055210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF163254, BC012924, BM968883, CA428013, DN995752
    Consensus CDS
    CCDS47112.1
    UniProtKB/Swiss-Prot
    Q8TCK5, Q9UHF2, Q9UN19
    Related
    ENSP00000423602.1, ENST00000512369.2
    Conserved Domains (2) summary
    cd10355
    Location:28 → 119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    cd10573
    Location:163 → 258
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    99816827..99872333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008024.2 → XP_016863513.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

    Conserved Domains (3) summary
    cd10355
    Location:28 → 119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    pfam00169
    Location:166 → 231
    PH; PH domain
    cl17171
    Location:163 → 230
    PH-like; Pleckstrin homology-like domain

  2. XM_011531840.3 → XP_011530142.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1

    See identical proteins and their annotated locations for XP_011530142.1

    Conserved Domains (2) summary
    cd10355
    Location:28 → 119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    cd10573
    Location:163 → 258
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain

  3. XM_017008023.2 → XP_016863512.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

    Conserved Domains (3) summary
    cd10355
    Location:28 → 119
    SH2_DAPP1_BAM32_like; Src homology 2 domain found in dual adaptor for phosphotyrosine and 3-phosphoinositides ( DAPP1)/B lymphocyte adaptor molecule of 32 kDa (Bam32)-like proteins
    pfam00169
    Location:166 → 231
    PH; PH domain
    cl17171
    Location:163 → 230
    PH-like; Pleckstrin homology-like domain

  4. XM_011531843.4 → XP_011530145.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X3

    Conserved Domains (2) summary
    cd10573
    Location:41 → 136
    PH_DAPP1; Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides Pleckstrin homology (PH) domain
    pfam00169
    Location:44 → 133
    PH; PH domain

RNA

  1. XR_007096391.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    103132302..103187798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349680.1 → XP_054205655.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1

  2. XM_054349681.1 → XP_054205656.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

  3. XM_054349682.1 → XP_054205657.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2

  4. XM_054349683.1 → XP_054205658.1  dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X3

RNA

  1. XR_008486964.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UN19.1 GenPept UniProtKB/Swiss-Prot:Q9UN19

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