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    Top1 topoisomerase (DNA) I [ Mus musculus (house mouse) ]

    Gene ID: 21969, updated on 13-Jan-2025

    Summary

    Official Symbol
    Top1provided by MGI
    Official Full Name
    topoisomerase (DNA) Iprovided by MGI
    Primary source
    MGI:MGI:98788
    See related
    Ensembl:ENSMUSG00000070544 AllianceGenome:MGI:98788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top-1; D130064I21Rik
    Summary
    Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within DNA replication; DNA topological change; and embryonic cleavage. Located in cytoplasm; male germ cell nucleus; and perikaryon. Is expressed in brain; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA topoisomerase I). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 28.9), adrenal adult (RPKM 26.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Top1 in Genome Data Viewer
    Location:
    2 H2; 2 80.96 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (160487901..160564684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (160645897..160722764)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14221 Neighboring gene STARR-positive B cell enhancer ABC_E6011 Neighboring gene predicted gene, 57688 Neighboring gene STARR-positive B cell enhancer ABC_E646 Neighboring gene STARR-seq mESC enhancer starr_06260 Neighboring gene STARR-seq mESC enhancer starr_06261 Neighboring gene predicted gene, 54128 Neighboring gene STARR-seq mESC enhancer starr_06265 Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene STARR-positive B cell enhancer ABC_E6012 Neighboring gene predicted gene, 35129

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables DNA binding  
    enables DNA binding, bending  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables chromatin DNA binding  
    enables chromatin binding  
    enables chromatin binding  
    enables double-stranded DNA binding  
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    enables single-stranded DNA binding  
    enables single-stranded DNA binding  
    enables supercoiled DNA binding  
    enables supercoiled DNA binding  
    Process Evidence Code Pubs
    involved_in DNA replication  
    acts_upstream_of_or_within DNA replication PubMed 
    involved_in DNA topological change  
    acts_upstream_of_or_within DNA topological change PubMed 
    involved_in DNA topological change  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in chromosome segregation  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    acts_upstream_of_or_within embryonic cleavage PubMed 
    involved_in peptidyl-serine phosphorylation  
    involved_in rRNA transcription  
    involved_in response to xenobiotic stimulus  
    Component Evidence Code Pubs
    located_in P-body  
    located_in P-body  
    located_in cytoplasm PubMed 
    located_in dense fibrillar component  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in male germ cell nucleus PubMed 
    located_in nuclear chromosome  
    colocalizes_with nuclear chromosome  
    is_active_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in perikaryon PubMed 
    part_of protein-DNA complex  
    part_of protein-DNA complex  

    General protein information

    Preferred Names
    DNA topoisomerase 1
    Names
    DNA topoisomerase I
    NP_001400077.1
    NP_001400078.1
    NP_001400079.1
    NP_033434.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413148.1NP_001400077.1  DNA topoisomerase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL590414, AL591673
    2. NM_001413149.1NP_001400078.1  DNA topoisomerase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL590414, AL591673
    3. NM_001413150.1NP_001400079.1  DNA topoisomerase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL590414, AL591673
    4. NM_009408.3NP_033434.2  DNA topoisomerase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL590414, AL591673
      Consensus CDS
      CCDS16995.1
      UniProtKB/Swiss-Prot
      A2A4B7, Q04750
      Related
      ENSMUSP00000105094.3, ENSMUST00000109468.3
      Conserved Domains (4) summary
      smart00435
      Location:362739
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:434637
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:217431
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:697765
      Topo_C_assoc; C-terminal topoisomerase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      160487901..160564684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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