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    Med1 mediator complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 19014, updated on 4-Jan-2025

    Summary

    Official Symbol
    Med1provided by MGI
    Official Full Name
    mediator complex subunit 1provided by MGI
    Primary source
    MGI:MGI:1100846
    See related
    Ensembl:ENSMUSG00000018160 AllianceGenome:MGI:1100846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; l11Jus15
    Summary
    Enables several functions, including nuclear receptor binding activity; promoter-specific chromatin binding activity; and transcription coregulator activity. Involved in several processes, including camera-type eye development; circulatory system development; and myeloid cell development. Acts upstream of or within several processes, including hemopoiesis; mammary gland development; and regulation of signal transduction. Located in nucleus. Part of mediator complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and lung. Used to study congestive heart failure and dilated cardiomyopathy. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.6), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Med1 in Genome Data Viewer
    Location:
    11 D; 11 61.75 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98042980..98084121, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98152154..98193313, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene STARR-positive B cell enhancer ABC_E10712 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:98063825-98064126 Neighboring gene predicted gene, 38963 Neighboring gene cyclin dependent kinase 12 Neighboring gene microRNA 5119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC90617

    Gene Ontology Provided by MGI

    Items 1 - 25 of 47
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor binding  
    enables LBD domain binding  
    enables LBD domain binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables general transcription initiation factor binding  
    enables general transcription initiation factor binding  
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables nuclear estrogen receptor binding  
    enables nuclear estrogen receptor binding  
    enables nuclear receptor binding PubMed 
    enables nuclear receptor binding  
    enables nuclear receptor coactivator activity  
    enables nuclear receptor coactivator activity  
    enables nuclear retinoic acid receptor binding  
    enables nuclear retinoic acid receptor binding  
    enables nuclear retinoic acid receptor binding  
    enables nuclear thyroid hormone receptor binding  
    enables nuclear thyroid hormone receptor binding  
    enables nuclear thyroid hormone receptor binding  
    enables nuclear vitamin D receptor binding  
    enables nuclear vitamin D receptor binding  
    enables nuclear vitamin D receptor binding  
    enables peroxisome proliferator activated receptor binding  
    enables peroxisome proliferator activated receptor binding  
    enables promoter-specific chromatin binding PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables protein-containing complex binding  
    enables transcription coactivator activity PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity PubMed 
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    enables transcription coregulator activity  
    enables transcription coregulator activity  
    enables transcription coregulator activity  
    enables transcription corepressor activity PubMed 
    enables ubiquitin protein ligase activity  
    contributes_to ubiquitin protein ligase activity  
    Items 1 - 25 of 47
    Items 1 - 25 of 88
    Process Evidence Code Pubs
    acts_upstream_of G0 to G1 transition PubMed 
    involved_in RNA polymerase II preinitiation complex assembly PubMed 
    involved_in androgen biosynthetic process  
    involved_in androgen biosynthetic process  
    involved_in angiogenesis PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within animal organ regeneration PubMed 
    acts_upstream_of_or_within brain development PubMed 
    acts_upstream_of_or_within camera-type eye development PubMed 
    involved_in cell morphogenesis  
    involved_in cell morphogenesis  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus PubMed 
    involved_in cellular response to steroid hormone stimulus  
    involved_in cellular response to thyroid hormone stimulus  
    involved_in cellular response to thyroid hormone stimulus  
    involved_in cellular response to thyroid hormone stimulus  
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    acts_upstream_of_or_within embryonic hemopoiesis PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis PubMed 
    acts_upstream_of_or_within embryonic placenta development PubMed 
    acts_upstream_of_or_within enucleate erythrocyte development PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation PubMed 
    acts_upstream_of_or_within erythrocyte development PubMed 
    involved_in erythrocyte development PubMed 
    acts_upstream_of_or_within fat cell differentiation PubMed 
    acts_upstream_of_or_within fat cell differentiation  
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in keratinocyte differentiation  
    involved_in keratinocyte differentiation  
    acts_upstream_of_or_within lactation PubMed 
    involved_in lens development in camera-type eye PubMed 
    acts_upstream_of_or_within liver development PubMed 
    involved_in mRNA transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within mammary gland branching involved in pregnancy PubMed 
    acts_upstream_of_or_within mammary gland branching involved in thelarche PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation PubMed 
    involved_in megakaryocyte development PubMed 
    acts_upstream_of_or_within monocyte differentiation PubMed 
    acts_upstream_of_or_within multicellular organism development PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of keratinocyte proliferation  
    involved_in negative regulation of keratinocyte proliferation  
    involved_in negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in nuclear receptor-mediated steroid hormone signaling pathway  
    involved_in nuclear receptor-mediated steroid hormone signaling pathway  
    acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway PubMed 
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of G0 to G1 transition PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of hepatocyte proliferation PubMed 
    acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway PubMed 
    involved_in positive regulation of keratinocyte differentiation  
    involved_in positive regulation of keratinocyte differentiation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription elongation by RNA polymerase II PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon-mediated signaling pathway PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of RNA biosynthetic process  
    involved_in regulation of RNA biosynthetic process  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of vitamin D receptor signaling pathway PubMed 
    involved_in retinal pigment epithelium development PubMed 
    acts_upstream_of_or_within thyroid hormone generation PubMed 
    involved_in thyroid hormone receptor signaling pathway  
    involved_in thyroid hormone receptor signaling pathway  
    acts_upstream_of_or_within transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II PubMed 
    involved_in ventricular trabecula myocardium morphogenesis PubMed 
    Items 1 - 25 of 88
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    part_of core mediator complex  
    part_of mediator complex  
    part_of mediator complex PubMed 
    part_of mediator complex PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-DNA complex  
    part_of protein-DNA complex  
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 1
    Names
    PPAR-binding protein
    Ppar binding protein
    TR-interacting protein 2
    peroxisome proliferator-activated receptor-binding protein
    thyroid hormone receptor-associated protein complex 220 kDa component
    thyroid receptor-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080118.2NP_001073587.1  mediator of RNA polymerase II transcription subunit 1 isoform 3

      See identical proteins and their annotated locations for NP_001073587.1

      Status: VALIDATED

      Source sequence(s)
      AL591205
      Consensus CDS
      CCDS36300.1
      UniProtKB/Swiss-Prot
      A2A526, A2A528, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925J9, Q925K0
      Related
      ENSMUSP00000103169.3, ENSMUST00000107545.9
      Conserved Domains (1) summary
      pfam10744
      Location:60426
      Med1; Mediator of RNA polymerase II transcription subunit 1
    2. NM_001361950.2NP_001348879.1  mediator of RNA polymerase II transcription subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591205
      Consensus CDS
      CCDS88244.1
      UniProtKB/TrEMBL
      B1AQH6
      Related
      ENSMUSP00000090411.6, ENSMUST00000092735.12
      Conserved Domains (1) summary
      pfam10744
      Location:60426
      Med1; Mediator of RNA polymerase II transcription subunit 1
    3. NM_001361951.2NP_001348880.1  mediator of RNA polymerase II transcription subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591205
      Conserved Domains (1) summary
      pfam10744
      Location:60426
      Med1; Mediator of RNA polymerase II transcription subunit 1
    4. NM_013634.3NP_038662.2  mediator of RNA polymerase II transcription subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_038662.2

      Status: VALIDATED

      Source sequence(s)
      AL591205
      Consensus CDS
      CCDS25341.1
      UniProtKB/Swiss-Prot
      Q925J9
      Related
      ENSMUSP00000018304.6, ENSMUST00000018304.7
      Conserved Domains (1) summary
      pfam10744
      Location:45411
      Med1; Mediator of RNA polymerase II transcription subunit 1
    5. NM_134027.3NP_598788.2  mediator of RNA polymerase II transcription subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_598788.2

      Status: VALIDATED

      Source sequence(s)
      AL591205
      UniProtKB/Swiss-Prot
      Q925J9
      Conserved Domains (1) summary
      pfam10744
      Location:60426
      Med1; Mediator of RNA polymerase II transcription subunit 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98042980..98084121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532504.3XP_006532567.1  mediator of RNA polymerase II transcription subunit 1 isoform X1

      Conserved Domains (1) summary
      pfam10744
      Location:60426
      Med1; Mediator of RNA polymerase II transcription subunit 1
    2. XM_006532505.3XP_006532568.1  mediator of RNA polymerase II transcription subunit 1 isoform X2

      Conserved Domains (1) summary
      pfam10744
      Location:60426
      Med1; Mediator of RNA polymerase II transcription subunit 1

    RNA

    1. XR_004936845.1 RNA Sequence

    2. XR_388366.5 RNA Sequence

    3. XR_001779920.3 RNA Sequence

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