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    Cd55b CD55 molecule, decay accelerating factor for complement B [ Mus musculus (house mouse) ]

    Gene ID: 13137, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cd55bprovided by MGI
    Official Full Name
    CD55 molecule, decay accelerating factor for complement Bprovided by MGI
    Primary source
    MGI:MGI:104849
    See related
    Ensembl:ENSMUSG00000026401 AllianceGenome:MGI:104849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Daf; Daf2; Daf-TM; TM-DAF
    Summary
    This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in testis adult (RPKM 55.5), spleen adult (RPKM 8.2) and 8 other tissues See more
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    Genomic context

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    See Cd55b in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130316263..130350831, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130388526..130423097, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_02191 Neighboring gene STARR-seq mESC enhancer starr_02192 Neighboring gene predicted gene 29428 Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene predicted gene, 41951 Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene CD55 molecule, decay accelerating factor for complement Neighboring gene predicted gene 16083 Neighboring gene zona pellucida 3 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional analysis of mouse decay accelerating factor (CD55). Harris CL, et al. Biochem J, 1999 Aug 1. PMID 10417349, Free PMC Article
    2. Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Sun X, et al. Proc Natl Acad Sci U S A, 1999 Jan 19. PMID 9892684, Free PMC Article
    3. A new repetitive sequence uniquely present in the decay-accelerating factor genes. Nonaka M, et al. Immunogenetics, 1998. PMID 9435343
    4. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. Spicer AP, et al. J Immunol, 1995 Sep 15. PMID 7545711
    5. Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis. Aly M, et al. Genes Immun, 2007 Apr. PMID 17287827

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156369

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement decay-accelerating factor transmembrane isoform
    Names
    complement-transmembrane
    decay accelerating factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317361.1 → NP_001304290.1  complement decay-accelerating factor transmembrane isoform isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC111067, CJ046619, CJ236680, L41365
      Consensus CDS
      CCDS83587.1
      UniProtKB/TrEMBL
      A0JP41, E9Q731
      Related
      ENSMUSP00000113352.2, ENSMUST00000119432.2
      Conserved Domains (3) summary
      cd00033
      Location:34 → 93
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:161 → 218
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      pfam00084
      Location:96 → 156
      Sushi; Sushi repeat (SCR repeat)

    2. NM_001404948.1 → NP_001391877.1  complement decay-accelerating factor transmembrane isoform isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC111067, AC116692

    3. NM_007827.3 → NP_031853.2  complement decay-accelerating factor transmembrane isoform isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC111067, CJ046619, CJ236680, L41365
      Consensus CDS
      CCDS35699.1
      UniProtKB/Swiss-Prot
      E9QLT3, Q61476
      UniProtKB/TrEMBL
      E9QAP4
      Related
      ENSMUSP00000108107.3, ENSMUST00000112488.9
      Conserved Domains (3) summary
      cd00033
      Location:223 → 283
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:161 → 218
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      pfam00084
      Location:96 → 156
      Sushi; Sushi repeat (SCR repeat)

    RNA

    1. NR_175893.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC111067, AC116692

    2. NR_175894.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC111067, AC116692

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130316263..130350831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314396.3 → XP_017169885.1  complement decay-accelerating factor transmembrane isoform isoform X4

      UniProtKB/Swiss-Prot
      E9QLT3, Q61476
      Conserved Domains (2) summary
      cd00033
      Location:52 → 111
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:110 → 297
      PHA02927; secreted complement-binding protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61476.2 GenPept UniProtKB/Swiss-Prot:Q61476

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