Marveld3 MARVEL domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Marveld3provided by RGD
Official Full Name: MARVEL domain containing 3provided by RGD
Primary source: RGD:1562056
See related: EnsemblRapid:ENSRNOG00000016291 AllianceGenome:RGD:1562056
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562056
Summary: Predicted to enable mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in bicellular tight junction assembly. Predicted to act upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and protein localization to cell junction. Predicted to be located in bicellular tight junction and cytoplasmic vesicle. Predicted to be active in cytoplasm. Orthologous to human MARVELD3 (MARVEL domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 73.1), Lung (RPKM 20.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54818180..54832871, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37908727..37923420, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (41710076..41724923)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.
Title: Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell junction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to osmotic stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MARVEL domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.