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Conserved domains on  [gi|564395765|ref|XP_006255660|]
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MARVEL domain-containing protein 3 isoform X1 [Rattus norvegicus]

Protein Classification

MARVEL domain-containing protein( domain architecture ID 10472694)

MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing protein may be involved in membrane apposition and vesicle-trafficking events

Gene Ontology:  GO:0016020
PubMed:  12468223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SF-CC1 super family cl36939
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 32-147 1.97e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


The actual alignment was detected with superfamily member TIGR01622:

Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 49.53  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395765   32 ERPRDPGGDRHRERNGDVRGNGDRRAGREHRTDREPRQDRHRDaGHRAAEQRAREKSRQSRARPEPWGPSWDtagtpgpa 111
Cdd:TIGR01622   8 ERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRD-RDYYRGRERRSRSRRPNRRYRPREKRRR-------- 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 564395765  112 pwRGPEPPLKHGLGRRGLESELASERYISTYSEPAR 147
Cdd:TIGR01622  79 --RGDSYRRRRDDRRSRREKPRARDGTPEPLTEDER 112
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 230-355 2.07e-05

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


:

Pssm-ID: 366555  Cd Length: 136  Bit Score: 43.86  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395765  230 AQQLDVQFYQLKLPTVTAAMAYSGALmtfsCLLLLGGALRVPWHCPLWLVIEGLMDALIAGAYVPALYFFfqhlsAAYSS 309
Cdd:pfam01284  28 IAYAGSYPSAVNFAVFVAVFSFLIAL----FFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIAL-----AAALR 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 564395765  310 DVCkerealyqSKGYSGFNCGLHGGDIGTGVFAAMAIGVFAVGAIL 355
Cdd:pfam01284  99 GHS--------ENQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
 
Name Accession Description Interval E-value
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 32-147 1.97e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 49.53  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395765   32 ERPRDPGGDRHRERNGDVRGNGDRRAGREHRTDREPRQDRHRDaGHRAAEQRAREKSRQSRARPEPWGPSWDtagtpgpa 111
Cdd:TIGR01622   8 ERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRD-RDYYRGRERRSRSRRPNRRYRPREKRRR-------- 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 564395765  112 pwRGPEPPLKHGLGRRGLESELASERYISTYSEPAR 147
Cdd:TIGR01622  79 --RGDSYRRRRDDRRSRREKPRARDGTPEPLTEDER 112
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 230-355 2.07e-05

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 43.86  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395765  230 AQQLDVQFYQLKLPTVTAAMAYSGALmtfsCLLLLGGALRVPWHCPLWLVIEGLMDALIAGAYVPALYFFfqhlsAAYSS 309
Cdd:pfam01284  28 IAYAGSYPSAVNFAVFVAVFSFLIAL----FFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIAL-----AAALR 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 564395765  310 DVCkerealyqSKGYSGFNCGLHGGDIGTGVFAAMAIGVFAVGAIL 355
Cdd:pfam01284  99 GHS--------ENQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 32-94 1.38e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 40.66  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395765  32 ERPRDPGGDRHRERNGDVRGNGDRRAGREHRTDREPRQDRHRDAGHRAAEQRAREKSRQSRAR 94
Cdd:PRK12678 172 RRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRD 234
 
Name Accession Description Interval E-value
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 32-147 1.97e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 49.53  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395765   32 ERPRDPGGDRHRERNGDVRGNGDRRAGREHRTDREPRQDRHRDaGHRAAEQRAREKSRQSRARPEPWGPSWDtagtpgpa 111
Cdd:TIGR01622   8 ERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRHRD-RDYYRGRERRSRSRRPNRRYRPREKRRR-------- 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 564395765  112 pwRGPEPPLKHGLGRRGLESELASERYISTYSEPAR 147
Cdd:TIGR01622  79 --RGDSYRRRRDDRRSRREKPRARDGTPEPLTEDER 112
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 230-355 2.07e-05

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 43.86  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564395765  230 AQQLDVQFYQLKLPTVTAAMAYSGALmtfsCLLLLGGALRVPWHCPLWLVIEGLMDALIAGAYVPALYFFfqhlsAAYSS 309
Cdd:pfam01284  28 IAYAGSYPSAVNFAVFVAVFSFLIAL----FFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIAL-----AAALR 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 564395765  310 DVCkerealyqSKGYSGFNCGLHGGDIGTGVFAAMAIGVFAVGAIL 355
Cdd:pfam01284  99 GHS--------ENQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 32-94 1.38e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 40.66  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564395765  32 ERPRDPGGDRHRERNGDVRGNGDRRAGREHRTDREPRQDRHRDAGHRAAEQRAREKSRQSRAR 94
Cdd:PRK12678 172 RRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRD 234
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 32-93 2.79e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 39.89  E-value: 2.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564395765  32 ERPRDPGGDRHRERNGDVRGNGDRRAGREHRTDREPRQDRHRDAGHRAAEQRAREKSRQSRA 93
Cdd:PRK12678 160 AAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRR 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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