Gpr142 G protein-coupled receptor 142 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr142provided by MGI
Official Full Name: G protein-coupled receptor 142provided by MGI
Primary source: MGI:MGI:2668437
See related: Ensembl:ENSMUSG00000034677 AllianceGenome:MGI:2668437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGR2
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cell junction and cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gonad; hemolymphoid system; sensory organ; and trigeminal ganglion. Orthologous to human GPR142 (G protein-coupled receptor 142). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114689750..114697571)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114798924..114806745)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The importance of Gpr142 in the maintenance of pancreatic beta-cell function.
Title: The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent.
GPR142 functions as a sensor of aromatic amino acids, controlling GIP but also CCK and GLP-1 as well as insulin and glucagon in the pancreas.
Title: The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
these findings demonstrate GPR142 is a Tryptophan receptor critically required for insulin and incretin hormone regulation and suggest GPR142 agonists may be effective therapies that leverage amino acid sensing pathways for the treatment of type 2 diabetes.
Title: GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism.
GPR142 mRNA showed a ubiquitous expression both in the brain and in various peripheral glands and organs in pre- and postnatal development.
Title: Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable G-protein coupled receptor 142

Names: G protein-coupled receptor PGR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346772.1 → NP_001333701.1 probable G-protein coupled receptor 142 isoform 2

Status: VALIDATED

Source sequence(s)

AL663079, AL669969

Consensus CDS

CCDS83922.1

UniProtKB/TrEMBL

Q1XA02

Related

ENSMUSP00000102194.2, ENSMUST00000106584.2
NM_001379097.1 → NP_001366026.1 probable G-protein coupled receptor 142 isoform 3

Status: VALIDATED

Source sequence(s)

AL669969

UniProtKB/TrEMBL

A0A1C9J7L2

Conserved Domains (2) summary

cd14964
Location:48 → 74

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:47 → 315

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_181749.1 → NP_861414.1 probable G-protein coupled receptor 142 isoform 1

See identical proteins and their annotated locations for NP_861414.1

Status: VALIDATED

Source sequence(s)

AY288428

Consensus CDS

CCDS25611.1

UniProtKB/Swiss-Prot

Q7TQN9

UniProtKB/TrEMBL

A2AD24

Related

ENSMUSP00000045029.3, ENSMUST00000045319.9

Conserved Domains (1) summary

pfam00001
Location:94 → 321

7tm_1; 7 transmembrane receptor (rhodopsin family)