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Conserved domains on  [gi|32306534|ref|NP_861414|]
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probable G-protein coupled receptor 142 isoform 1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
70-332 4.87e-147

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15129:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 270  Bit Score: 416.49  E-value: 4.87e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLGLPV------ALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANI 143
Cdd:cd15129   1 VIPVIYYSVLLCLGLPVniltavALSRLAVRTKKSSYYYLLALTASDILTQVFIIFVGFILQTAILAREVPHALIHTVSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWA 223
Cdd:cd15129  81 LEFAANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFYWWSDMWRDSHPPTTLDKVLKWT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 224 HCLIVYFIPCNVFLVTNSAIILRLRKR-GQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLA 302
Cdd:cd15129 161 HCFIIYFIPCTIFLVTNSVIIHKLRRRkGRSGPQRRSGKTTAILLAITTVFAVLWAPRTVVIIYHLYVSSVNRDWRVHLA 240
                       250       260       270
                ....*....|....*....|....*....|
gi 32306534 303 LDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15129 241 LDLANMLAMLNTAVNFFLYCFVSKRFRRTV 270
 
Name Accession Description Interval E-value
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
70-332 4.87e-147

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 416.49  E-value: 4.87e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLGLPV------ALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANI 143
Cdd:cd15129   1 VIPVIYYSVLLCLGLPVniltavALSRLAVRTKKSSYYYLLALTASDILTQVFIIFVGFILQTAILAREVPHALIHTVSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWA 223
Cdd:cd15129  81 LEFAANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFYWWSDMWRDSHPPTTLDKVLKWT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 224 HCLIVYFIPCNVFLVTNSAIILRLRKR-GQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLA 302
Cdd:cd15129 161 HCFIIYFIPCTIFLVTNSVIIHKLRRRkGRSGPQRRSGKTTAILLAITTVFAVLWAPRTVVIIYHLYVSSVNRDWRVHLA 240
                       250       260       270
                ....*....|....*....|....*....|
gi 32306534 303 LDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15129 241 LDLANMLAMLNTAVNFFLYCFVSKRFRRTV 270
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
94-321 9.00e-18

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 81.96  E-value: 9.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534    94 RTRKPSYHYLLALTASDIVTQVIIVFVgFLLQGAVLARQV-PQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLR 172
Cdd:pfam00001  14 KLRTPTNIFLLNLAVADLLFSLLTLPF-WLVYYLNHGDWPfGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLR 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534   173 HRATSSPGRTHRAIAAVIGVTLLTGIP---FYWWLDVWR--------DADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNS 241
Cdd:pfam00001  93 YKRRRTPRRAKVLILVIWVLALLLSLPpllFGWTLTVPEgnvtvcfiDFPEDLSKPVSYTLLISVLGFLLPLLVILVCYT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534   242 AIILRLRK---RGQRGLRPLVSKSTAILLG-VTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVN 317
Cdd:pfam00001 173 LIIRTLRKsasKQKSSERTQRRRKALKTLAvVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALSVTLWLAYVNSCLN 252

                  ....
gi 32306534   318 FGLY 321
Cdd:pfam00001 253 PIIY 256
 
Name Accession Description Interval E-value
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
70-332 4.87e-147

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 416.49  E-value: 4.87e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLGLPV------ALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANI 143
Cdd:cd15129   1 VIPVIYYSVLLCLGLPVniltavALSRLAVRTKKSSYYYLLALTASDILTQVFIIFVGFILQTAILAREVPHALIHTVSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWA 223
Cdd:cd15129  81 LEFAANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFYWWSDMWRDSHPPTTLDKVLKWT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 224 HCLIVYFIPCNVFLVTNSAIILRLRKR-GQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLA 302
Cdd:cd15129 161 HCFIIYFIPCTIFLVTNSVIIHKLRRRkGRSGPQRRSGKTTAILLAITTVFAVLWAPRTVVIIYHLYVSSVNRDWRVHLA 240
                       250       260       270
                ....*....|....*....|....*....|
gi 32306534 303 LDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15129 241 LDLANMLAMLNTAVNFFLYCFVSKRFRRTV 270
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
71-329 1.21e-89

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 270.62  E-value: 1.21e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  71 IPVIYYSVLLSLGLP------VALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANIL 144
Cdd:cd15919   2 VPVIYYSLLLCLGLPaniltvIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNKQMPQVLDKIIEVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 145 EFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAH 224
Cdd:cd15919  82 EFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWIEDYTSTSMHHVLIWIH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 225 CLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVS-KSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLAL 303
Cdd:cd15919 162 CFTVYLVPCSIFFVLNSIIVYKLRRKSNFRLRGYSTgKTTAILFTITSIFAILWAPRIIMILYHLYVSPINNSWLVHIVS 241
                       250       260
                ....*....|....*....|....*.
gi 32306534 304 DIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15919 242 DIANMLALLNTAINFFLYCFISKRFR 267
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
70-332 9.83e-45

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 155.87  E-value: 9.83e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLGLP------VALARLaaRTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLA----RQVPQAVVR 139
Cdd:cd14978   1 VLYGYVLPVICIFGIIgnilnlVVLTRK--SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSssflSYFYAYFLP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 140 TANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTM--- 216
Cdd:cd14978  79 YIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSyyy 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 217 -------------DKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKS------------TAILLGVTS 271
Cdd:cd14978 159 viptllrqnetylLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRllsrsqrrerrtTIMLIAVVI 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32306534 272 LFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd14978 239 VFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
72-325 1.21e-40

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 144.11  E-value: 1.21e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  72 PVIYYSVLLSLGLPVALARLAA-----RTRKPSYHYLLALTASDIVTqVIIVFVGFLLQGAVLARQVPQAVVRTANILEF 146
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSlvrlrKRPRSTRLLLASLAACDLLA-SLVVLVLFFLLGLTEASSRPQALCYLIYLLWY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 147 AANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKL------L 220
Cdd:cd14964  80 GANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLicttiyL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 221 KWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQR------GLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPvh 294
Cdd:cd14964 160 TWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAirsaasLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALVAA-- 237
                       250       260       270
                ....*....|....*....|....*....|.
gi 32306534 295 rDWRVHLALDIANMLAMLNTEVNFGLYCFIS 325
Cdd:cd14964 238 -GQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
94-325 9.06e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 87.73  E-value: 9.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTQVIIV--FVGFLLQGAVLArqvPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPL 171
Cdd:cd00637  28 RLRTVTNYFILNLAVADLLVGLLVIpfSLVSLLLGRWWF---GDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPL 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 172 RHRATSSPGRTHRAIAAV-IGVTLLTGIPFYWW-------LDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAI 243
Cdd:cd00637 105 RYRRRFTRRRAKLLIALIwLLSLLLALPPLLGWgvydyggYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRI 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 244 ILRLRKRGQRGLRPLVS-----------KSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRdwRVHLALDIANMLAML 312
Cdd:cd00637 185 FRKLRRHRRRIRSSSSNssrrrrrrrerKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSP--LPRILYFLALLLAYL 262
                       250
                ....*....|...
gi 32306534 313 NTEVNFGLYCFIS 325
Cdd:cd00637 263 NSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
94-321 9.00e-18

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 81.96  E-value: 9.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534    94 RTRKPSYHYLLALTASDIVTQVIIVFVgFLLQGAVLARQV-PQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLR 172
Cdd:pfam00001  14 KLRTPTNIFLLNLAVADLLFSLLTLPF-WLVYYLNHGDWPfGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLR 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534   173 HRATSSPGRTHRAIAAVIGVTLLTGIP---FYWWLDVWR--------DADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNS 241
Cdd:pfam00001  93 YKRRRTPRRAKVLILVIWVLALLLSLPpllFGWTLTVPEgnvtvcfiDFPEDLSKPVSYTLLISVLGFLLPLLVILVCYT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534   242 AIILRLRK---RGQRGLRPLVSKSTAILLG-VTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVN 317
Cdd:pfam00001 173 LIIRTLRKsasKQKSSERTQRRRKALKTLAvVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALSVTLWLAYVNSCLN 252

                  ....
gi 32306534   318 FGLY 321
Cdd:pfam00001 253 PIIY 256
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
94-329 1.29e-14

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 72.98  E-value: 1.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTqVIIVFVGFLLQGaVLARQVPQAVVRTA-NILEFAANHASVWIAVLFTVDRYNALCRPLR 172
Cdd:cd14967  29 RLRTVTNYFIVSLAVADLLV-ALLVMPFSAVYT-LLGYWPFGPVLCRFwIALDVLCCTASILNLCAISLDRYLAITRPLR 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 173 HRATSSPGRTHRAIAAV-IGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAH----CLIVYFIPCNVFLVTNsAIILRL 247
Cdd:cd14967 107 YRQLMTKKRALIMIAAVwVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYvlvsSVISFFIPLLIMIVLY-ARIFRV 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 248 RKRGQRglrplVSKSTAILLGVtslFALLWAPRIIVMLYHLYvapvHRDWRVHLAL-DIANMLAMLNTEVNFGLYCFISK 326
Cdd:cd14967 186 ARRELK-----AAKTLAIIVGA---FLLCWLPFFIIYLVSAF----CPPDCVPPILyAVFFWLGYLNSALNPIIYALFNR 253

                ...
gi 32306534 327 TFR 329
Cdd:cd14967 254 DFR 256
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
94-329 9.97e-12

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 64.93  E-value: 9.97e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDI--------VTQVIIVFVGFLLqGAVLARQVP--QAVVRTANILEFAAnhasvwIAVlftvDR 163
Cdd:cd14993  30 HMRTVTNYFLVNLAVADLlvslfcmpLTLLENVYRPWVF-GEVLCKAVPylQGVSVSASVLTLVA------ISI----DR 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 164 YNALCRPLRHRATSSPGRTHRAIAAV-------------------IGVTLLTGIPFYWWLDVWrdadPPSTMDKLLKWAH 224
Cdd:cd14993  99 YLAICYPLKARRVSTKRRARIIIVAIwviaiiimlpllvvyeleeIISSEPGTITIYICTEDW----PSPELRKAYNVAL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 225 CLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTA------------ILLGVTSLFALLWAPRIIVMLYHLYVAP 292
Cdd:cd14993 175 FVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSrrilrskkkvarMLIVVVVLFALSWLPYYVLSILLDFGPL 254
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32306534 293 VHRDWRVHLA--LDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd14993 255 SSEESDENFLliLPFAQLLGYSNSAINPIIYCFMSKKFR 293
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
83-332 5.86e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 62.31  E-value: 5.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  83 GLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANIleFAANHASVWIAVLFTVD 162
Cdd:cd14972  17 SLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL--VLSLLASAYSLLAIAVD 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 163 RYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTG-IPFYWWLDVWRDADPPSTMDKLLKWAH---CLIVYFIPCNVFLV 238
Cdd:cd14972  95 RYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAlLPVLGWNCVLCDQESCSPLGPGLPKSYlvlILVFFFIALVIIVF 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 239 TNSAIILRLRKR---------GQRGLRPLVSKSTAI-LLGVTSLFALLWAPRIIVMLYHLYVAPVHRDwrvHLALDIANM 308
Cdd:cd14972 175 LYVRIFWCLWRHanaiaarqeAAVPAQPSTSRKLAKtVVIVLGVFLVCWLPLLILLVLDVLCPSVCDI---QAVFYYFLV 251
                       250       260
                ....*....|....*....|....
gi 32306534 309 LAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd14972 252 LALLNSAINPIIYAFRLKEMRRAV 275
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
96-332 6.69e-10

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 59.29  E-value: 6.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  96 RKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRA 175
Cdd:cd14979  32 RTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 176 TSSPGRTHRAIAAVIGVTLLTGIPFYWWLD-VWRDADPPSTMDkllKWAHCLIV-----------------YFIPCNVFL 237
Cdd:cd14979 112 LVTKRRVKRFILAIWLVSILCAIPILFLMGiQYLNGPLPGPVP---DSAVCTLVvdrstfkyvfqvstfifFVLPMFVIS 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 238 VTNSAIILRLRKR-------------------GQRGLRPLVskstAILLGVTSLFALLWAP----RIIVMLYHLYVAPVH 294
Cdd:cd14979 189 ILYFRIGVKLRSMrnikkgtraqgtrnvelslSQQARRQVV----KMLGAVVIAFFVCWLPfhaqRLMFSYASKEDTFLF 264
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306534 295 rdWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd14979 265 --DFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
145-329 8.36e-10

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 59.27  E-value: 8.36e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 145 EFAANhASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAH 224
Cdd:cd15134  82 EMSSY-ASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLEYPPTSGEALEESAF 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 225 CLIVYFIP---------CNVFLVT-----------------NSAIILRLRKRGQRGLRPLVSKSTAI--LLGVTSLFALL 276
Cdd:cd15134 161 CAMLNEIPpitpvfqlsTFLFFIIpmiaiivlyvliglqlrRSTLLRRGQRSVSGGRRSSQSRRTVLrmLVAVVVAFFIC 240
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32306534 277 WAPRIIVMLYHLY-VAPVHRDWRVHLALD-IANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15134 241 WAPFHAQRLLTVYaKNMTPPYLFINRILFyISGVLYYVSSTVNPILYNVMSAKYR 295
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
94-329 2.72e-09

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 57.40  E-value: 2.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTQVI---IVFVGFLLQGAVLArqvpQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRP 170
Cdd:cd15206  30 RMRTVTNVFLLNLAVSDLLLAVFcmpFTLVGQLLRNFIFG----EVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHP 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 171 LRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVwRDADPPSTMDKLLKWAHC-----------LIVYFIPCNVFLVT 239
Cdd:cd15206 106 LKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNL-IPMSRPGGHKCREVWPNEiaeqawyvfldLMLLVIPGLVMSVA 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 240 NSAIILRLRKRGQRGLRplvskstaILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFG 319
Cdd:cd15206 185 YGLISWTLLEAKKRVIR--------MLFVIVVEFFICWTPLYVINTWKAFDPPSAARYVSSTTISLIQLLAYISSCVNPI 256
                       250
                ....*....|
gi 32306534 320 LYCFISKTFR 329
Cdd:cd15206 257 TYCFMNKRFR 266
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
151-329 1.00e-08

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 55.76  E-value: 1.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRD-----------ADPPSTMDKL 219
Cdd:cd14970  85 TSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEeggtiscnlqwPDPPDYWGRV 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 220 LKwAHCLIVYF-IPCNVFLVTNSAIILRLRKRGQRGLRPLVSKS------TAILLGVTSLFALLWAPRIIVMLYHLYVAP 292
Cdd:cd14970 165 FT-IYTFVLGFaVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRrarrkvTRLVLVVVAVFVVCWLPFHVFQIVRLLIDP 243
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 32306534 293 VHRDWRVHLALdIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd14970 244 PETLTVVGVFL-FCIALSYANSCLNPILYAFLDENFR 279
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
150-329 1.21e-08

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 55.38  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPS-----TMDKLLKWA- 223
Cdd:cd15096  85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEaysycTFLTEVGTAa 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 224 ------HCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVS------KSTAILLGVTSLFALLWAPRIIVMLYHLYVA 291
Cdd:cd15096 165 qtfftsFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAEsqrgkrRVTRLVVVVVVVFAICWLPIHIILLLKYYGV 244
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 32306534 292 PVHRDWRVHLALdIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15096 245 LPETVLYVVIQI-LSNCLAYGNSCVNPILYAFLSQNFR 281
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
150-332 2.37e-08

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 54.58  E-value: 2.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWL-DVWRDADPPSTMDKL---LKWAHC 225
Cdd:cd14982  85 YGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRsTIAKENNSTTCFEFLsewLASAAP 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 226 LIV------YFIPCNVFLVTNSAIILRLRKRG-QRGLRPLVSKSTAILLGVTSLFALLWAP----RIIVMLYHLYV-APV 293
Cdd:cd14982 165 IVLialvvgFLIPLLIILVCYSLIIRALRRRSkQSQKSVRKRKALRMILIVLAVFLVCFLPyhvtRILYLLVRLSFiADC 244
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 32306534 294 HRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd14982 245 SARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
151-329 8.99e-08

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 53.07  E-value: 8.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSspgRTHRAIAAVIG-VTLLTGIPFYWWLDV-----------------WRDaDP 212
Cdd:cd15390  86 ASVFTLMAISIDRYIAIVHPLRPRLSR---RTTKIAIAVIWlASFLLALPQLLYSTTetyyyytgsertvcfiaWPD-GP 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 213 PSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRG------QRGLRPLVSKSTAI--LLGVTSLFALLWAPriivm 284
Cdd:cd15390 162 NSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKtigentPRQLESVRAKRKVVkmMIVVVVIFAICWLP----- 236
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306534 285 lYHLYVAPVHRDWRVHLALDIANM------LAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15390 237 -YHLYFILTYLYPDINSWKYIQQIylaiywLAMSNSMYNPIIYCWMNKRFR 286
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
71-332 1.66e-07

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 52.00  E-value: 1.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  71 IPVIYYSV----LLSLGLPVALARLAARTRKPSYHYLLALTASDIvtqviIVFVGFLLQGAVLARQ----VPQAVVRTAN 142
Cdd:cd14985   3 IPALYIAIflvgLLGNLFVVWVFLFPRGPKRVADIFIANLAAADL-----VFVLTLPLWATYTANQydwpFGAFLCKVSS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 143 ILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVW---RDADPPSTMDK- 218
Cdd:cd14985  78 YVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQaieNLNKTACIMLYp 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 219 LLKWAHCLIV------YFIPCNVFLVTNSAIILRLRKRGQRGL--RPLVSKSTAILLGVTSLFALLWAP-RIIVMLYHLY 289
Cdd:cd14985 158 HEAWHFGLSLelnilgFVLPLLIILTCYFHIARSLRKRYERTGknGRKRRKSLKIIFALVVAFLVCWLPfHFFKFLDFLA 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32306534 290 VAPVHRDWRVHLALD----IANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd14985 238 QLGAIRPCFWELFLDlglpIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
136-329 2.09e-07

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 51.64  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 136 AVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRaTSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDAD---- 211
Cdd:cd15002  72 FVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQV-TIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGvylc 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 212 ------PPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVS----KSTAILLGVTSLFALLWAPRI 281
Cdd:cd15002 151 ilcippLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQirsrKLTHMLLSVVLAFTILWLPEW 230
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 32306534 282 IVMLYhlYVAPVHRDWRVHLALDI-ANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15002 231 VAWLW--LIHIKSSGSSPPQLFNVlAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
94-336 2.66e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 51.49  E-value: 2.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTQVIIVFVGFllqgavlarqvpqaVVRTANILEFAANHASVWIA--VLF-----------T 160
Cdd:cd15307  30 RLQNVTNYFLMSLAITDLMVAVLVMPLGI--------------LTLVKGHFPLSSEHCLTWICldVLFctasimhlctiS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 161 VDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPfywwLDVWRDADPPSTM--------DKLLKWAHCLIVYFIP 232
Cdd:cd15307  96 VDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLP----LSLMYSKDHASVLvngtcqipDPVYKLVGSIVCFYIP 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 233 CNVFLVT---NSAIILRLRKRGQRGLRpLVSKSTAILLGVTSLFALLWAPRIIVMLYhLYVAPVHRDWRVHLALDIANML 309
Cdd:cd15307 172 LGVMLLTyclTVRLLARQRSRHGRIIR-LEQKATKVLGVVFFTFVILWSPFFVLNLL-PTVCAECEERISHWVFDVVTWL 249
                       250       260
                ....*....|....*....|....*..
gi 32306534 310 AMLNTEVNFGLYCFISKTFRATVRQVI 336
Cdd:cd15307 250 GYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
160-329 2.94e-07

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 51.51  E-value: 2.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 160 TVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVW-----------RDADPPSTMDKLLKWAHCLIV 228
Cdd:cd15095  95 SVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEegywygpqtycREVWPSKAFQKAYMIYTVLLT 174
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 229 YFIPCNVFLVTNSAIILRLRKRGQRG--LRPLVS--------KSTAILLGVTSLFALLWAP-RIIVMLYHLYVAPvHRDW 297
Cdd:cd15095 175 YVIPLAIIAVCYGLILRRLWRRSVDGnnQSEQLSeralrqkrKVTRMVIVVVVLFAICWLPnHVLNLWQRFDPNF-PETY 253
                       170       180       190
                ....*....|....*....|....*....|..
gi 32306534 298 RVHLALDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15095 254 ATYALKIAALCLSYANSAVNPFVYAFMGENFR 285
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
152-329 2.94e-07

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 51.46  E-value: 2.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 152 SVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTM-----------DKLL 220
Cdd:cd15123  87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTtfeacapypvsEKIL 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 221 KWAHCLIV----YFIPCNVFLVTNSAIILRLRK-------------RGQRGLRPLVSKSTAILLGvtsLFALLWAPRIIV 283
Cdd:cd15123 167 QEIHSLLCflvfYIIPLSIISVYYFLIARTLYKstfnmpaeehshaRKQIESRKRVAKTVLVLVA---LFAFCWLPNHIL 243
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 32306534 284 MLYHLYVAPVHRDWRV-HLALDI-ANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15123 244 YLYRSFTYHTSVDSSAfHLIATIfSRVLAFSNSCVNPFALYWLSKSFR 291
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
142-329 1.66e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 49.00  E-value: 1.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 142 NILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIP--FYWWLDVWRDADPPSTMDKL 219
Cdd:cd14971  77 HYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPvlALHRLRNYTPGNRTVCSEAW 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 220 LKWAH--------CLIVYFIPCNVFLVTNSAIILRL-----RKRGQRGLRPLVSKSTAILLGVTSLFALLWAP-RIIVML 285
Cdd:cd14971 157 PSRAHrrafalctFLFGYLLPLLLICVCYAAMLRHLwrvavRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPiHAILLL 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 32306534 286 YHLYVAPVHrdwRVHLALDI-ANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd14971 237 VALGPFPLT---YATYALRIwAHCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
152-330 2.65e-06

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 48.51  E-value: 2.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 152 SVWIAVLFTVDRYNALCRPLRHRATSSpgRTHRAIAAVIGVTLLTGIPF----------------YWWLDVWrdadPPST 215
Cdd:cd15392  88 SAFTLVAISIDRYVAIMWPLRPRMTKR--QALLLIAVIWIFALATALPIaitsrlfedsnascgqYICTESW----PSDT 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 216 MDKLLKWAHCLIVYFIPCNVFLVTNSAIILRL----------RKRGQRgLRPLVSKSTAILLGVTSLFALLWAPRIIVML 285
Cdd:cd15392 162 NRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVwakrtpgeaeNNRDQR-MAESKRKLVKMMITVVAIFALCWLPLNILNL 240
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 32306534 286 YHLYVAPV-HRDWRVHLALdIANMLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15392 241 VGDHDESIySWPYIPYLWL-AAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
70-330 4.17e-06

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 47.76  E-value: 4.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLG----LPVALARLAART-RKPSYHYLLALTASDIvtqviIVFVGFLLQGAVLARQVPQAVV------ 138
Cdd:cd14995   1 VVATFLVLLICGVGivgnIMVVLVVLRTRHmRTPTNCYLVSLAVADL-----MVLVAAGLPNEIESLLGPDSWIygyagc 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 139 RTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLD----VWRDADPPS 214
Cdd:cd14995  76 LLITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDlsikHYGDDIVVR 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 215 TMDKLLKWAHcLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVA-PV 293
Cdd:cd14995 156 CGYKVSRHYY-LPIYLADFVLFYVIPLLLAIVLYGLIGRILFSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFASpPY 234
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306534 294 HRDWrvhlALDIANMLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd14995 235 LDLW----FLLFCRTCIYLNSAINPILYNLMSQKFRA 267
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
226-331 5.71e-06

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 47.44  E-value: 5.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 226 LIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHR---DWRVHLA 302
Cdd:cd14991 171 LLEFFLPLGLIVFCSVRIACNLRIRQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGScrcLNSVAQL 250
                        90       100
                ....*....|....*....|....*....
gi 32306534 303 LDIANMLAMLNTEVNFGLYCFISKTFRAT 331
Cdd:cd14991 251 FHISLAFTYLNSALDPVIYCFSSPWFRNS 279
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
72-332 6.02e-06

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 47.27  E-value: 6.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  72 PVIYYSVLLSLGL---PVALARLAARTRKPS--YHYLLALTASDIVtqVIIVFVGFLLQGAVLAR-QVPQAVVRTANILE 145
Cdd:cd15001   2 VIIVYVITFVLGLignSLVIFVVARFRRMRSvtNVFLASLATADLL--LLVFCVPLKTAEYFSPTwSLGAFLCKAVAYLQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 146 FAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIP-----------------FYWWLDVWr 208
Cdd:cd15001  80 LLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPvlfgqglvryesengvtVYHCQKAW- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 209 dadPPSTMDKLLKWAHCLIVYFIPcnvFLVTNSAIILRLRKRgqrglrplVSKstaILLGVTSLFALLWAPRIIVMLYHL 288
Cdd:cd15001 159 ---PSTLYSRLYVVYLAIVIFFIP---LIVMTFAYARDTRKQ--------VIK---MLISVVVLFAVCWGPLLIDNLLVS 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32306534 289 YVAPVHRDWRVHLALDIA-NMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15001 222 FDVISTLHTQALKYMRIAfHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
150-329 6.71e-06

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 46.99  E-value: 6.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTM------DKLLKWA 223
Cdd:cd15180  83 YCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTEcvhnfpQSDTYWW 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 224 HCL------IVYFIPCNVFLVTNSAIILRLRkRGQRGLRPLvsKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVH--- 294
Cdd:cd15180 163 LALrllyhiVGFLLPLAVMVYCYTSILLRLL-RSSQGFQKQ--RAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVldr 239
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 32306534 295 ---RDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15180 240 ncgTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
70-283 2.23e-05

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 45.56  E-value: 2.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLGLP-------VALARLAARTRKPSYHYLLALTASD-IVTQVIIVFVGFL-LQGAVLArqvpQAVVRT 140
Cdd:cd15122   1 ATGTIFLLLAALLGLPgngfiiwSILWKMKARGRSVTCILILNLAVADgAVLLLTPFFITFLtRKTWPFG----QAVCKA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 141 ANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADP------PS 214
Cdd:cd15122  77 VYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMndricePC 156
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32306534 215 TMDKLLKWAH----CLIVYFIPCNVFLVTNSAIILRLR-KRGQRGLRplVSKSTAILLgvtSLFALLWAPRIIV 283
Cdd:cd15122 157 HASRGHAIFHytfeTLVAFVLPFGVILFSYSVILVRLKgARFRRRAR--VEKLIAAIV---VAFALLWVPYHVV 225
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
144-250 2.55e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 45.36  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTM------- 216
Cdd:cd14997  80 VELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPvavcrtp 159
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 32306534 217 -DKLLKWAHCLIV----YFIPCNVFLVTNSAIILRLRKR 250
Cdd:cd14997 160 aDTFWKVAYILSTivvfFVVPLAILSGLYSVICRRLVGH 198
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
151-331 2.72e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 45.16  E-value: 2.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLD------------VWRDADPPSTMdK 218
Cdd:cd15094  85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYAStvpdsgrysctiVWPDSSAVNGQ-K 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 219 LLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKS----TAILLGVTSLFALLWAPRIIVMLYHLYVAPVH 294
Cdd:cd15094 164 AFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRShrkvTRLVLTVISVYIICWLPYWAFQVHLIFLPPGT 243
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 32306534 295 R--DWRVHLALdIANMLAMLNTEVNFGLYCFISKTFRAT 331
Cdd:cd15094 244 DmpKWEILMFL-LLTVLSYANSMVNPLLYAFLSENFRKS 281
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
94-331 3.51e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 45.00  E-value: 3.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTQVIIV--FVGFLLQGAvlaRQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPL 171
Cdd:cd15049  30 QLRTVNNYFLLSLACADLIIGLVSMnlYTVYLVMGY---WPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPL 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 172 RHRATSSPGRTHRAIAAVIGVTLLTGIP--FYWWLDVWRDADPPSTM------DKLLKWAHCLIVYFIPCNVfLVTNSAI 243
Cdd:cd15049 107 TYRAKRTPKRAILMIALAWVISFVLWAPaiLGWQYFVGERTVPDGQCyiqfldDPAITFGTAIAAFYLPVLV-MTILYWR 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 244 ILRLRKRGQRGLRPLvsksTAILLGvtslFALLWAPRIIVMLYHLYVAPVHRDwrvhLALDIANMLAMLNTEVNFGLYCF 323
Cdd:cd15049 186 IYRETARERKAARTL----SAILLA----FIITWTPYNILVLVSTFCAKCIPD----TLWSFGYWLCYINSTINPFCYAL 253

                ....*...
gi 32306534 324 ISKTFRAT 331
Cdd:cd15049 254 CNKTFRKT 261
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
71-329 3.64e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 44.81  E-value: 3.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  71 IPVIYYSV--LLSLG---LPVALARLAARTRKPSYHYLLALTASDIVtqVIIVFVGFLLQGAVLARQV-PQAVVRTANIL 144
Cdd:cd15979   2 VRILLYSVifLLSVFgnmLIIVVLGLNKRLRTVTNSFLLSLALSDLM--LAVFCMPFTLIPNLMGTFIfGEVICKAVAYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 145 EFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAA--VIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKW 222
Cdd:cd15979  80 MGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAAtwLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 223 AH-----------CLIVYFIPCNVFLVTNSAIILRLrkrgqrgLRPLVSKSTAI--LLGVTSLFALLWAPRIIVMLYHLY 289
Cdd:cd15979 160 PSaqvrqawyvllLLILFFIPGVVMIVAYGLISREL-------YRGLLAKKRVIrmLVVIVAMFFLCWLPIFSANTWRAF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32306534 290 VAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15979 233 DPLSAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFR 272
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
151-332 5.46e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 44.15  E-value: 5.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRaTSSPGRTHRAIAAVIGVTLLTGIP--FYWWL--------DVWRDADPPSTMDKLL 220
Cdd:cd15196  86 ASSYVLVATAIDRYIAICHPLSSH-RWTSRRVHLMVAIAWVLSLLLSIPqlFIFSYqevgsgvyDCWATFEPPWGLRAYI 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 221 KWAhCLIVYFIPCNVFLVTNSAIILRLRKRgqrglrplVSKSTAILLGVTSLFALLWAPRIIVMLYHLY--VAPVHrdwr 298
Cdd:cd15196 165 TWF-TVAVFVVPLIILAFCYGRICYVVWRA--------KIKTVKLTLVVVACYIVCWTPFFVVQMWAAWdpTAPIE---- 231
                       170       180       190
                ....*....|....*....|....*....|....
gi 32306534 299 vHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15196 232 -GPAFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
151-337 1.35e-04

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 42.89  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRAtsSPGRTHRAIAAVIGVTLLTGI---PFYWWLDVWRDADPPSTMDKLLKWAHCLI 227
Cdd:cd15295  86 ASVYNIVLISYDRYQSVSNAVSYRN--QQTATLRIVTQMVAVWVLAFLvhgPAILVSDSWKTEDGECEPEFFSNWYILAI 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 228 V----YFIPCNVFLVTNSAIILRLRKRgqrgLRPL-VSKSTAILLGVtslFALLWAPRIIVMLYhLYVAPVHRDwrvHLA 302
Cdd:cd15295 164 TsvleFLVPVILVAYFNTQIYWSLWKR----LRDRkLAKSLAIILGT---FAICWAPYSLFTII-RAACEKHRG---SPW 232
                       170       180       190
                ....*....|....*....|....*....|....*
gi 32306534 303 LDIANMLAMLNTEVNFGLYCFISKTFRATVRQVIC 337
Cdd:cd15295 233 YNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIFC 267
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
152-332 1.49e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 42.86  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 152 SVWIAVLFTVDRYNALCRPLRHRATSSpGRTHRAIAAVIGVT-LLTGIPFYWWLDVWRDADPPSTMDKLL----KWAHCL 226
Cdd:cd15380  87 SIFLVVAISQDRYRTLVHTMTSRRQRS-RRQAQVICLLIWVFgGLLSIPTFLFRSVKHVPDLNISACILLfpheAWHFAR 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 227 IVYF------IPCNVFLVTNSAIILRLRKRGQRGLR----PLVSKSTAILLGVTSLFALLWAP-RIIVMLYHLYVAPVHR 295
Cdd:cd15380 166 RVELnivgflLPLAAIVFFNFHIIASLRERTEESRKrcggLKDTKATRLILTLVLMFLVCWTPyHFFAFLDFLFQVEVIQ 245
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32306534 296 D--WR--VHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15380 246 GcfWEefIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTKV 286
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
70-338 1.60e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 42.90  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  70 IIPVIYYSVLLSLGLpvalaRLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAAN 149
Cdd:cd15306  11 IIPTIGGNILVILAV-----SLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAV--IGVTLLTGIPFYWWLDvwrDADPPSTMDKLLKWAH--- 224
Cdd:cd15306  86 TASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVwlISIGIAIPVPIKGIET---DVDNPNNITCVLTKERfgd 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 225 -----CLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRplvsKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDwRV 299
Cdd:cd15306 163 filfgSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQ----RASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQT-TL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32306534 300 HLALDIANMLAMLNTEVNFGLYCFISKTFR-ATVRQVICD 338
Cdd:cd15306 238 QMLMEIFVWIGYVSSGVNPLVYTLFNKTFRdAFGRYITCN 277
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
150-332 1.65e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 42.76  E-value: 1.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPgRTHRAIAAVIGVT-LLTGIPFYWWLDVWRDAD---------PPSTMDKL 219
Cdd:cd15160  85 YASIGFLCCIAVDRYLAVVHPLRFRGLRTR-RFALKVSASIWVLeLGTHSVFLGHDELFRDEPnhtlcyekyPMEGWQAS 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 220 LKWAHCLIVYFIPCNVFLVTNSAIiLRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDW-- 297
Cdd:cd15160 164 YNYARFLVGFLIPLSLILFFYRRV-LRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGLcg 242
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 32306534 298 ---RVHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15160 243 fekRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
94-329 1.69e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 42.94  E-value: 1.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTQVIIV---FVGFLLQGAVLArqvpQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRP 170
Cdd:cd15978  30 RMRTVTNIFLLSLAVSDLMLCLFCMpftLIPNLLKDFIFG----SAVCKTATYFMGISVSVSTFNLVAISLERYSAICKP 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 171 LRHRATSSPGRTHRAIAA--VIGVTLLTGIPFYWWL-DVWRDADPPSTMDKLLkWAH-----------CLIVYFIPCNVF 236
Cdd:cd15978 106 LKSRVWQTKSHALKVIAAtwCLSFTIMLPYPIYSNLvPFTRINNSTGNMCRLL-WPNdvtqqswyiflLLILFLIPGIVM 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 237 LVTNSAIILRLrkrgQRGLRPLVSKSTAI--LLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNT 314
Cdd:cd15978 185 MTAYGLISLEL----YRGIKFLMAKKRVIrmLIVIVILFFLCWTPIFSANAWRAFDTRSADRLLSGAPISFIHLLSYTSA 260
                       250
                ....*....|....*
gi 32306534 315 EVNFGLYCFISKTFR 329
Cdd:cd15978 261 CVNPIIYCFMNKRFR 275
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
94-329 1.76e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 42.88  E-value: 1.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  94 RTRKPSYHYLLALTASDIVTQVIIVFVGFllQGAVLARQV-PQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLR 172
Cdd:cd15202  30 RMRTVTNYFIVNLAVADIMITLFNTPFTF--VRAVNNTWIfGLFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLK 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 173 HRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDA-------------DPPSTMDKLLKWAHCLIVYFIPCNVFLVT 239
Cdd:cd15202 108 PRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSedivrslcledwpERADLFWKYYDLALFILQYFLPLLVISFA 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 240 NSAIILRLRK-------RGQRGLRPLVSKSTAI--LLGVTSLFALLWAPRIIVMLYhLYVAPVHRdWRVHLALDIANM-L 309
Cdd:cd15202 188 YARVGIKLWAsnmpgdaTTERYFALRRKKKKVIkmLMVVVVLFALCWLPFNIYVLL-LSSKPDYL-IKTINAVYFAFHwL 265
                       250       260
                ....*....|....*....|
gi 32306534 310 AMLNTEVNFGLYCFISKTFR 329
Cdd:cd15202 266 AMSSTCYNPFIYCWLNERFR 285
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
136-330 1.79e-04

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 42.82  E-value: 1.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 136 AVVRTANILEFAAnhasvwiavlFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDA----D 211
Cdd:cd15193  81 AVNRCSSILFLTG----------MSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESvcveD 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 212 PPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLR--PLVSKSTAILLGVTSLFALLWAPRIIVMLYHLY 289
Cdd:cd15193 151 SSSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRtgRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLL 230
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 32306534 290 VA------PVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15193 231 LElgggvlPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
152-332 2.05e-04

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 42.45  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 152 SVWIAVLFTVDRYNALCRPLRHRATSSPgRTHRAIAAVI-GVTLLTGIPFYWWLDVWRDADPPSTMDKLL------KWAH 224
Cdd:cd15189  87 SIYLLVMISQDRYLALVKTMAARRLRRR-RYAKLICVLIwVVGLLLSIPTFLLRKIKAIPDLNITACVLLypheawHFAH 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 225 CLIV----YFIPCNVFLVTNSAIILRLRKRGQRGLRPLV--SKSTAILLGVTSLFALLWAPRIIV----MLYHLYVAPVH 294
Cdd:cd15189 166 IVLLnivgFLLPLLVITFCNYNILQALRTREESTRCEDRndSKATALVLAVTLLFLVCWGPYHFFtfldFLFDVGVLDEC 245
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 32306534 295 RDWR-VHLALDIANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15189 246 FWEHfIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRKV 284
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
152-329 2.23e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 42.63  E-value: 2.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 152 SVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWW-----------LDVWRDADPPSTMDKLL 220
Cdd:cd15089  86 SIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMavtktprdgavVCMLQFPSPSWYWDTVT 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 221 KWAHCLIVYFIPCNVFLVTNSAIILRLR--------KRGQRGLRplvsKSTAILLGVTSLFALLWAPRIIVMLYHLYVAP 292
Cdd:cd15089 166 KICVFIFAFVVPILVITVCYGLMILRLRsvrllsgsKEKDRNLR----RITRMVLVVVAAFIICWTPIHIFVIVWTLVDI 241
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 32306534 293 VHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15089 242 DRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFK 278
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
150-330 2.81e-04

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 42.12  E-value: 2.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMD-------KLLKW 222
Cdd:cd15097  86 YASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPgweearrKAMDT 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 223 AHCLIVYFIPCNVFLVTNSAIILRLRK-----RGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLY----VAPV 293
Cdd:cd15097 166 CTFAFGYLIPVLVVSLSYTRTIKYLWTavdplEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYgdfpFNQA 245
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 32306534 294 HRDWRVhlaldIANMLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15097 246 TYAFRL-----LSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
74-332 3.68e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 41.71  E-value: 3.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  74 IYYSVLLSLGLP-----VALARLAARTRKPSYHYLLALTASDIVTqviivFVGFLLQGAVLARQVP----QAVVRTANIL 144
Cdd:cd15928   5 AVCSVLMLVGASgnlltVLVIGRSRDMRTTTNLYLSSLAVSDLLI-----FLVLPLDLYRLWRYRPwrfgDLLCRLMYFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 145 EFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDV-------------WRDAD 211
Cdd:cd15928  80 SETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVehiqgqqtprgfeCTVVN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 212 PPSTMDKLLKWAHCLIvYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVS------KSTAILLGVTSL-FALLWAP-RIIV 283
Cdd:cd15928 160 VSSGLLSVMLWVSTSF-FFVPMVCLSLLYGLIGRALWDRRQRSRTAGASrrdnnhRQTVRMLAVIVLaFVLCWLPfHVGR 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 32306534 284 MLYHLYVAPVHRDWRVHLALDI-ANMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15928 239 VIFNHSRASTKHLHYVSQYFNLvSFVLFYLSAAINPILYNLMSKRYRYAV 288
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
144-331 5.25e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 41.11  E-value: 5.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIP--FYWWLDVWRDADPPSTM----- 216
Cdd:cd17790  79 LDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPaiLFWQYLVGERTVLAGQCyiqfl 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 217 -DKLLKWAHCLIVYFIPCNVfLVTNSAIILRLRKRGQRGLRPLvsksTAILLGvtslFALLWAPRIIVMLyhlyVAPVHR 295
Cdd:cd17790 159 sQPIITFGTAIAAFYLPVTI-MIILYWRIYRETIKEKKAARTL----SAILLA----FILTWTPYNIMVL----VSTFCK 225
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 32306534 296 DWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRAT 331
Cdd:cd17790 226 DCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDT 261
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
151-329 5.51e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 41.28  E-value: 5.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPF---YWWLDVWRDADPPSTMD---------- 217
Cdd:cd15012  85 ASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYfvfSQTVEILVTQDGQEEEIcvldremfns 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 218 KLLKWAHCLIVYFIPCNVFLVTNSAIILRL-RKRGQRGLRPLVSkstaILLGVTSLFALLWAPRIIVMLYHLYVAPVHRD 296
Cdd:cd15012 165 KLYDTINFIVWYLIPLLIMTVLYSKISIVLwKSSSIEARRKVVR----LLVAVVVSFALCNLPYHARKMWQYWSEPYRCD 240
                       170       180       190
                ....*....|....*....|....*....|....
gi 32306534 297 WRVHLALD-IANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15012 241 SNWNALLTpLTFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
142-330 7.09e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 41.14  E-value: 7.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 142 NILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAV-IGVTLLTGIPFYWWlDVWR--------DADP 212
Cdd:cd15048  77 LVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVwILAFLLYGPAIIGW-DLWTgysivptgDCEV 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 213 PSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVS---------------------------KSTAI 265
Cdd:cd15048 156 EFFDHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPilpasqnpsrarsqreqvklrrdrkaaKSLAI 235
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32306534 266 LLGVtslFALLWAPRIIVML----YHLYVapVHRDWrvhlaLDIANMLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15048 236 LVLV---FLICWAPYTILTIirsfCSGSC--VDSYL-----YEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
151-331 7.30e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 40.78  E-value: 7.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWldvWRDADPPSTMDKLLKWAHCLIVY- 229
Cdd:cd15064  86 ASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFG---WRTPDSEDPSECLISQDIGYTIFs 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 230 -----FIPCNVFLVTnSAIILRLRKRGQRGLRPLvskstAILLGVtslFALLWAPRIIVMLyhlyVAPVHRDWRVHLAL- 303
Cdd:cd15064 163 tfgafYIPLLLMLIL-YWKIYRAAARERKAAKTL-----GIILGA---FIVCWLPFFLVAL----IVPLCSHCWIPLALk 229
                       170       180
                ....*....|....*....|....*...
gi 32306534 304 DIANMLAMLNTEVNFGLYCFISKTFRAT 331
Cdd:cd15064 230 SFFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
78-332 7.76e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 40.92  E-value: 7.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  78 VLLSLGLPVALARlAARTRKPSYHYLLALTASDIVTQVIIVfVGFLLQGAVLARQVP-QAVVRTANIleFAANHASVWIA 156
Cdd:cd15102  15 VLENLLVLIAIWR-HMKFHRPMYYFLGNLALSDLLAGAAYL-ANILLSGARTLRLSPaQWFLREGSM--FVALSASVFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 157 VLFTVDRYNALCRPLRHRATSSpGRTHRAIAAVIGVTLLTG-IPFYWWlDVWRDADPPSTMDKLL--KWAHCLIVYFIPC 233
Cdd:cd15102  91 LAIAIERHLTMAKMKPYGASKT-SRVLLLIGACWLISLLLGgLPILGW-NCLGALDACSTVLPLYskHYVLFCVTIFAGI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 234 NVFLVTNSAIILRL-RKRGQRGLRPLVSKSTAILLG----VTSLFALLWAPRIIVMLyhLYVAPVHRDWRVHLALDIANM 308
Cdd:cd15102 169 LAAIVALYARIYCLvRASGRKATRASASPRSLALLKtvliVLLVFIACWGPLFILLL--LDVACPVKTCPILYKADWFLA 246
                       250       260
                ....*....|....*....|....
gi 32306534 309 LAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15102 247 LAVLNSALNPIIYTLRSRELRRAV 270
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
161-329 9.80e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 40.49  E-value: 9.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 161 VDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIP--FYWWLDVWRDA-------------DPPSTMDKLLKWAHC 225
Cdd:cd14992  96 FDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPqlYYATTEVLFSVknqekifccqippVDNKTYEKVYFLLIF 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 226 LIVYFIPCNVFLVTNSAIILRLRKRGQRG-------LRPLVSKSTAI--LLGVTSLFALLWAP----RIIVMLYHLYVAP 292
Cdd:cd14992 176 VVIFVLPLIVMTLAYARISRELWFRKVPGfsikeveRKRLKCKRRVIkmLVCVVVLFVICWLPfhlfFLLRDFFPLIMKE 255
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 32306534 293 VHrdwrVHLALDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd14992 256 KH----TLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
144-331 1.52e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 39.81  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPfywWLDVW-----RDADPPST--- 215
Cdd:cd15301  79 IDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPP---WIYSWpyiegKRTVPAGTcyi 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 216 ----MDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGvtslFALLWAPRIIVMLYHLYVA 291
Cdd:cd15301 156 qfleTNPYVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLA----FIVTWTPYNVLVLIKAFFP 231
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32306534 292 PvhrDWRVHLAL-DIANMLAMLNTEVNFGLYCFISKTFRAT 331
Cdd:cd15301 232 C---SDTIPTELwDFSYYLCYINSTINPLCYALCNAAFRRT 269
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
144-331 1.73e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 39.63  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAI--AAVIGVTLLTGIPFYWWLDVWRDADPPST------ 215
Cdd:cd15300  79 LDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIglAWLISFILWAPPILCWQYFVGKRTVPEREcqiqfl 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 216 MDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRgqrglRPLVSKSTAILLGvtslFALLWAPRIIVMLYHLYVAPVHR 295
Cdd:cd15300 159 SEPTITFGTAIAAFYIPVSVMTILYCRIYKETIKE-----RKAAQTLSAILLA----FIITWTPYNIMVLVSTFCSDCIP 229
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 32306534 296 DWRVHLALdianMLAMLNTEVNFGLYCFISKTFRAT 331
Cdd:cd15300 230 LTLWHLGY----WLCYVNSTVNPMCYALCNKTFRKT 261
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
96-329 1.93e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 39.44  E-value: 1.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  96 RKPSYHYLLALTASDIVTQVIivFVGFLLQGAVLARqvpqavVRTANILEF------AANHASVWIAVLFTVDRYNALCR 169
Cdd:cd15099  33 RRPSYLFIGSLALADMLASVI--FTISFLDFHVFHQ------RDSRNLFLFklggvtMAFTASVGSLLLTALDRYLCIYQ 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 170 PLRHRATSSPGRTHRA------IAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWA------HCLIVYFIPCNVFL 237
Cdd:cd15099 105 PSNYKLLVTRTRAKVAillmwcVTIIISFLPLMGWRCKTWDSPCSRLFPYIDRHYLASWTglqlvlLFLIIYAYPYILWK 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 238 VTNSAIILRLRKRGQRGLRPLVSKSTAILLGVT-----SLFALLWAPRIIVMLYHLYVAPVHrdwRVHLALDIANMLAML 312
Cdd:cd15099 185 AHRHEANMGGPKLGRQQVKGQARMRMDIRLAKTlslilLVLAICWLPVLAFMLVDVRVTLTN---KQKRMFAFCSMLCLV 261
                       250
                ....*....|....*..
gi 32306534 313 NTEVNFGLYCFISKTFR 329
Cdd:cd15099 262 NSCVNPIIYALRSRELR 278
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
102-321 2.02e-03

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 39.70  E-value: 2.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 102 YLLALTASDIVTQviIVFVGFLLQGAVLARQV-PQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRAtsSPG 180
Cdd:cd15393  38 FIANLAVADIIIG--LFSIPFQFQAALLQRWVlPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKARC--SKK 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 181 RTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTM-----------DKLLKWAHCLIV---YFIPCNVFLVTNSAIILR 246
Cdd:cd15393 114 SAKIIILIIWILALLVALPVALALRVEELTDKTNNGvkpfclpvgpsDDWWKIYNLYLVcvqYFVPLVIICYAYTRIAVK 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 247 LRKRGQRGLRPLV---------SKSTAILLGVTSLFALLWAPriiVMLYHL--YVAPVHRDWR-VHLALDIANMLAMLNT 314
Cdd:cd15393 194 IWGTKAPGNAQDVrddeilknkKKVIKMLIIVVALFALCWLP---LQTYNLlnEIKPEINKYKyINIIWFCSHWLAMSNS 270
                       250
                ....*....|
gi 32306534 315 EVN---FGLY 321
Cdd:cd15393 271 CYNpfiYGLY 280
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
86-330 2.48e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 39.28  E-value: 2.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  86 VALARLAARTRKPSYHYLLALTASDIVTQV-IIVFVGFLLQGAVLARQVPQAVVRTANILEFAAnhASVWIAVLFTVDRY 164
Cdd:cd15104  22 VALLKLIRKKDTKSNCFLLNLAIADFLVGLaIPGLATDELLSDGENTQKVLCLLRMCFVITSCA--ASVLSLAAIAFDRY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 165 NALCRPLRHRATSSPGRTHRAIAAVIGVTLLTG-IPFYWWLDVWRDADPPSTMDKLLK------------WAHCLIVYFI 231
Cdd:cd15104 100 LALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGfLPLISPQFQQTSYKGKCSFFAAFHprvllvlscmvfFPALLLFVFC 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 232 PCNVFLVT--NSAIILRLRKRGQRGLRPLVS-------KSTAILLGVtslFALLWAPRIIVMLYHLYVAPVH-RDW-RVH 300
Cdd:cd15104 180 YCDILKIArvHSRAIYKVEHALARQIHPRRTlsdfkaaRTVAVLIGC---FLLSWLPFQITGLVQALCDECKlYDVlEDY 256
                       250       260       270
                ....*....|....*....|....*....|
gi 32306534 301 LALdianmLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15104 257 LWL-----LGLCNSLLNPWIYAFWQKEVRR 281
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
151-330 2.62e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 39.04  E-value: 2.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTL------LTGIPFYWWL--------DVWrdaDPPSTM 216
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLssvqlfAGRTQRYGQYsegrvlcgESW---PGPDTS 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 217 DKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRG-------QRGLRPLVSKSTAI--LLGVTSLFALLWAPriivmlYH 287
Cdd:cd15391 163 RSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTapgnadkGRDDMQIKSKRKVIkmLVFVVLMFGICWLP------LH 236
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306534 288 LY--VAPVHRDWRV---HLALDIANM---LAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15391 237 LFnlVQDFSTVFRNmpqHTTRLIYGAchwIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
151-279 2.65e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 39.25  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 151 ASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPP--STMDKLLKWAHCLIV 228
Cdd:cd15053  87 ASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEecRFYNPDFIIYSSISS 166
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306534 229 YFIPCNVFLVTNSAIILRLRKRGQrglrplVSKSTAILLGVtslFALLWAP 279
Cdd:cd15053 167 FYIPCIVMLLLYYRIFRALRREKK------ATKTLAIVLGV---FLFCWLP 208
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
118-330 3.28e-03

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 38.69  E-value: 3.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 118 VFVGFLLQGAVLARqvpqavvrTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTG 197
Cdd:cd15092  60 IFLGFWPFGNALCK--------TVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVG 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 198 IPFYWWLDVWRDAD----------PPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLR--------KRGQRGLRplv 259
Cdd:cd15092 132 VPVMVMGSAQVEDEeieclveiptPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRgvrllsgsKEKDRNLR--- 208
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32306534 260 sKSTAILLGVTSLFALLWAP-RIIVMLYHLYVAPVHRDWRVHLALDIAnmLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15092 209 -RITRLVLVVVAVFVGCWTPiQIFVLAQGLGVQPSSETAVAILRFCTA--LGYVNSSLNPVLYAFLDENFKA 277
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
152-330 3.40e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 38.74  E-value: 3.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 152 SVWIAVLFTVDRYNALCRPLRHRATSSpgRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDK---LLKWAH---- 224
Cdd:cd15203  87 STLTLTAIAIDRYQLIVYPTRPRMSKR--HALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGyfcTESWPSsssr 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 225 -------CLIVYFIPCNVFLVTNSAIILRLRKR--GQRGLRPLVS-----------KSTAILLGVTSLFALLWAPRIIVM 284
Cdd:cd15203 165 liytisvLVLQFVIPLLIISFCYFRISLKLRKRvkKKRGKRTLSSrrrrselrrkrRTNRLLIAMVVVFAVCWLPLNLFN 244
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 32306534 285 LYHLYVAPVHRDWRVHLALD-IANMLAMLNTEVNFGLYCFISKTFRA 330
Cdd:cd15203 245 LLRDFEPLPQIDGRHFYLIFlICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
134-325 4.27e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 38.65  E-value: 4.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 134 PQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLR--HRATSspgRTHRAIAAVIGVTLLTGIPFYWWL------- 204
Cdd:cd15385  69 PDFLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKtlQQPTK---RSYLMIGSAWALSFILSTPQYFIFslseien 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 205 -----DVWRDADPPSTMDKLLKW---------------AHCLIVYFIPCNVFLVTNSAiiLRLRKRGQRGLRPLVSKSTA 264
Cdd:cd15385 146 gsgvyDCWANFIVPWGIKAYITWitisifvvpviilltCYGFICYNIWRNIKCKTRRG--LSDNALKNILLAVCVSSVKT 223
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32306534 265 I----------LLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFIS 325
Cdd:cd15385 224 IsrakirtvkmTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDESENTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
150-332 5.23e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 38.09  E-value: 5.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 150 HASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTL---------LTGIPFYWWLDVWR-DADPPSTMDKL 219
Cdd:cd15389  85 YVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLslphaiyqkLVEFEYSNERTRSRcLPSFPEPSDLF 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 220 LKW---AHCLIVYFIPCNVFLVTNSAIILRLRKRGQRG---------LRPLVSKSTAILLGVTSLFALLWAPriiVMLYH 287
Cdd:cd15389 165 WKYldlATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGdvtteqyvaQRRKKKKTIKMLMLVVLLFAICWLP---LNCYH 241
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 32306534 288 LYVApvHRDWRVHLALDIA-NMLAMLNTEVNFGLYCFISKTFRATV 332
Cdd:cd15389 242 VLLS--SHPIRSNSALFFAfHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
144-336 7.46e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 37.62  E-value: 7.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAI--AAVIGVTLLTGIPFYWWLDVWRDADPPST------ 215
Cdd:cd15299  82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIglAWVISFVLWAPAILFWQYFVGKRTVPPDEcfiqfl 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 216 MDKLLKWAHCLIVYFIPCNVFlvtnSAIILRLRKRGQRGLRPLVSKStAILLGvtslFALLWAPRIIVMLYHLYVAPVHR 295
Cdd:cd15299 162 SEPIITFGTAIAAFYLPVTIM----TILYWRIYKETIKEKKAAQTLS-AILLA----FIITWTPYNIMVLVNTFCDSCIP 232
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32306534 296 DwrvhLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVI 336
Cdd:cd15299 233 K----TYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLL 269
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
96-331 7.48e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 37.90  E-value: 7.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534  96 RKPSYHYLLALTASDIVTQVIIV--FVGFLLQGAVLARQVPQAVVRTANilefAANHASVWIAVLFTVDRYNALCRPLRH 173
Cdd:cd15341  33 RKPSYLFIGSLALADFLASVVFAcsFVDFHVFHGVDSSAIFLLKLGGVT----MSFTASLGSLLLMAFDRYVCIYYPSEY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 174 RATSSPGRTHRAIAAVIGVTLLTG-IPFYWWLDVWRDAD-----PPSTMDKLLKWAhCLIVYFIPCNVFlvTNSAIILRL 247
Cdd:cd15341 109 KALVTRKRALVALAVMWVLTALIAyLPLMGWNCCPLNSPcselfPLIPNDYLLSWL-LLVAILLSGIIY--TYGHVLWKA 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 248 RK-------------RGQRGLRPLVSKSTAILLgVTSLFALLWAPRIIVMLYHLYVApvhRDWRVHLALDIANMLAMLNT 314
Cdd:cd15341 186 HKhvvymekhqdqqgPGNARMRLDVRLAKTLGL-VLAVLLICWSPVLALMMHSLFTS---LSDHIKKAFAFCSTLCLVNS 261
                       250
                ....*....|....*..
gi 32306534 315 EVNFGLYCFISKTFRAT 331
Cdd:cd15341 262 MVNPIIYALRSRELRSS 278
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
147-329 8.96e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 37.62  E-value: 8.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 147 AANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVW-RDADPP------------ 213
Cdd:cd15130  87 ACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQnESDDGThpgglvctpivd 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306534 214 STMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRplvskstaILLGVTSLFALLWAPRIIVMLYHLYVApv 293
Cdd:cd15130 167 TATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQALRRGVL--------VLRAVVIAFVVCWLPYHVRRLMFCYIS-- 236
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 32306534 294 HRDWR------VHLALDIANMLAMLNTEVNFGLYCFISKTFR 329
Cdd:cd15130 237 DEQWTtflfdfYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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