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    DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 [ Homo sapiens (human) ]

    Gene ID: 3300, updated on 4-Jan-2025

    Summary

    Official Symbol
    DNAJB2provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B2provided by HGNC
    Primary source
    HGNC:HGNC:5228
    See related
    Ensembl:ENSG00000135924 MIM:604139; AllianceGenome:HGNC:5228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSJ1; CMT2T; DSMA5; HMNR5; HSJ-1; HSPF3
    Summary
    This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
    Expression
    Ubiquitous expression in brain (RPKM 54.3), testis (RPKM 27.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DNAJB2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219279366..219286895)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219764122..219771651)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220144088..220151617)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220109882-220110464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene serine/threonine kinase 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220142208-220142912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220150891-220151858 Neighboring gene Sharpr-MPRA regulatory region 13803 Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17149 Neighboring gene microRNA 153-1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:220199445-220200644 Neighboring gene regulated endocrine specific protein 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (28 hits/1269 screens)

    Associated conditions

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 2 (DNAJB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpr vpr HIV-1 Vpr downregulates DNAJ protein homolog HSJ1 in PHA-stimulated PBMC PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase activator activity  
    enables ATPase activator activity PubMed 
    enables Hsp70 protein binding  
    enables Hsp70 protein binding PubMed 
    enables Hsp70 protein binding PubMed 
    enables polyubiquitin modification-dependent protein binding PubMed 
    enables proteasome binding PubMed 
    enables protein binding PubMed 
    enables protein serine/threonine kinase binding PubMed 
    enables protein transporter activity PubMed 
    enables protein-folding chaperone binding PubMed 
    enables ubiquitin binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin-modified protein reader activity PubMed 
    enables unfolded protein binding  
    enables unfolded protein binding PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway PubMed 
    involved_in chaperone-mediated protein folding  
    involved_in chaperone-mediated protein folding PubMed 
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of inclusion body assembly PubMed 
    involved_in negative regulation of inclusion body assembly PubMed 
    involved_in negative regulation of protein binding PubMed 
    involved_in negative regulation of protein deubiquitination PubMed 
    involved_in neuron cellular homeostasis PubMed 
    involved_in positive regulation of ATP-dependent activity PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of protein ubiquitination PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in protein refolding  
    involved_in protein refolding PubMed 
    involved_in regulation of chaperone-mediated protein folding PubMed 
    involved_in regulation of protein localization PubMed 
    involved_in regulation of protein ubiquitination PubMed 
    involved_in response to unfolded protein PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasmic side of endoplasmic reticulum membrane PubMed 
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in inclusion body PubMed 
    located_in nuclear membrane  
    NOT located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    part_of proteasome complex PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 2
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 2
    dnaJ protein homolog 1
    heat shock 40 kDa protein 3
    heat shock protein J1
    heat shock protein, neuronal DNAJ-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029553.1 RefSeqGene

      Range
      5049..12578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039550.2 → NP_001034639.1  dnaJ homolog subfamily B member 2 isoform a

      See identical proteins and their annotated locations for NP_001034639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform a.
      Source sequence(s)
      AC114803, BC047056
      Consensus CDS
      CCDS46519.1
      UniProtKB/TrEMBL
      C9JXB9
      Related
      ENSP00000375936.4, ENST00000392086.8
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_006736.6 → NP_006727.2  dnaJ homolog subfamily B member 2 isoform b

      See identical proteins and their annotated locations for NP_006727.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1. This results in a longer isoform (b) with a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC114803, BC047056, BF795662, BT007088, BX478051, CA392563
      Consensus CDS
      CCDS2439.1
      UniProtKB/Swiss-Prot
      A8K9P6, P25686, Q53QD7, Q8IUK1, Q8IUK2, Q96F52
      UniProtKB/TrEMBL
      A8K0R1
      Related
      ENSP00000338019.5, ENST00000336576.10
      Conserved Domains (1) summary
      COG0484
      Location:3 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      219279366..219286895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219764122..219771651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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