trpm7 transient receptor potential cation channel, subfamily M, member 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trpm7provided by ZNC
Official Full Name: transient receptor potential cation channel, subfamily M, member 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-021115-2
See related: Ensembl:ENSDARG00000036232 AllianceGenome:ZFIN:ZDB-GENE-021115-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tct; cb495
Summary: Predicted to enable calcium channel activity. Acts upstream of or within several processes, including exocrine pancreas development; magnesium ion homeostasis; and melanocyte differentiation. Located in plasma membrane. Is expressed in several structures, including digestive system; immature eye; integument; nervous system; and renal system. Used to study sinoatrial node disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (113845..150663, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_007129.7 Chromosome 18 Reference GRCz11 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish trpm7 mutants show reduced motility in free movement.
Title: Zebrafish trpm7 mutants show reduced motility in free movement.
drTRPM7 has two protein domains that regulate inhibition by intracellular magnesium and nucleotides, and one domain that is concerned with sensing magnesium only.
Title: The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity.
Zebrafish gene was identified that when mutated produces semi-viable offspring and that may serve as a model of human diseases that have both pigmentation and neurological symptoms.
Title: Touchtone promotes survival of embryonic melanophores in zebrafish.
tct may represent a novel as well as selective regulator of melanoblast development within the neural crest lineage.
Title: Melanophore sublineage-specific requirement for zebrafish touchtone during neural crest development.
Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
Title: Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
TRPM7 plays a role within sensory neurons in modulating neutrotransmitter release at central synapses, similar to the role proprosed for mammalian TRPM7 at peripheral synapses.
Title: TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors.
Trpm7 regulates exocrine pancreatic development via the Mg(2+)-sensitive Socs3a pathway.
Title: Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer.
This study showed that stanniocalcin 1 (stc1)modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 activity is blocked.
Title: trpm7 regulation of in vivo cation homeostasis and kidney function involves stanniocalcin 1 and fgf23.
Mutation in trpm7 leads to defective skeletogenesis and kidney stone formation.
Title: Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7.
Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.
Title: Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fb77a02 (e-PCR)
- UniSTS:187522

G39945 (e-PCR)
- UniSTS:61695

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within magnesium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within melanin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metal ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic cation homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein tetramerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transient receptor potential cation channel subfamily M member 7

Names: nutria; touchtone; transient receptor potential melastatin 7

NP_001025232.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030061.1 → NP_001025232.1 transient receptor potential cation channel subfamily M member 7

See identical proteins and their annotated locations for NP_001025232.1

Status: PROVISIONAL

Source sequence(s)

AY860421

UniProtKB/TrEMBL

Q563W7

Related

ENSDARP00000145809.1, ENSDART00000188914.1

Conserved Domains (3) summary

smart00811
Location:1507 → 1725

Alpha_kinase; Alpha-kinase family

pfam00520
Location:868 → 1086

Ion_trans; Ion transport protein

pfam16519
Location:1179 → 1230

TRPM_tetra; Tetramerization domain of TRPM