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trpm7 transient receptor potential cation channel, subfamily M, member 7 [ Danio rerio (zebrafish) ]

Gene ID: 280653, updated on 9-Dec-2024

Summary

Official Symbol
trpm7provided by ZNC
Official Full Name
transient receptor potential cation channel, subfamily M, member 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-021115-2
See related
Ensembl:ENSDARG00000036232 AllianceGenome:ZFIN:ZDB-GENE-021115-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tct; cb495
Summary
Predicted to enable calcium channel activity. Acts upstream of or within several processes, including exocrine pancreas development; magnesium ion homeostasis; and melanocyte differentiation. Located in plasma membrane. Is expressed in several structures, including digestive system; immature eye; integument; nervous system; and renal system. Used to study sinoatrial node disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See trpm7 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (113845..150663, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488240 Neighboring gene ubiquitin specific peptidase 8 Neighboring gene uncharacterized LOC137488239 Neighboring gene leucine-rich repeat-containing protein 49 Neighboring gene La ribonucleoprotein 6, translational regulator a

Genomic regions, transcripts, and products

Genomic Sequence:
NC_007129.7 Chromosome 18 Reference GRCz11 Primary Assembly

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables calcium channel activity  
enables calcium channel activity  
enables kinase activity  
enables metal ion binding  
enables monoatomic ion channel activity  
enables nucleotide binding  
enables protein serine/threonine kinase activity  
enables transferase activity  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport  
involved_in calcium ion transport  
acts_upstream_of_or_within calcium ion transport  
acts_upstream_of_or_within developmental pigmentation PubMed 
acts_upstream_of_or_within exocrine pancreas development PubMed 
acts_upstream_of_or_within magnesium ion homeostasis PubMed 
acts_upstream_of_or_within melanin metabolic process PubMed 
acts_upstream_of_or_within melanocyte differentiation PubMed 
acts_upstream_of_or_within metal ion transport PubMed 
involved_in monoatomic cation homeostasis  
acts_upstream_of_or_within monoatomic cation homeostasis PubMed 
involved_in monoatomic cation transmembrane transport  
acts_upstream_of_or_within monoatomic ion transmembrane transport  
acts_upstream_of_or_within monoatomic ion transport  
acts_upstream_of_or_within ossification PubMed 
acts_upstream_of_or_within phosphorylation  
acts_upstream_of_or_within protein phosphorylation  
acts_upstream_of_or_within protein tetramerization  
acts_upstream_of_or_within regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within regulation of heart rate PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle PubMed 
acts_upstream_of_or_within regulation of neurotransmitter secretion PubMed 
acts_upstream_of_or_within renal system process PubMed 
acts_upstream_of_or_within skeletal system development PubMed 
acts_upstream_of_or_within transmembrane transport  
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 7
Names
nutria
touchtone
transient receptor potential melastatin 7
NP_001025232.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030061.1NP_001025232.1  transient receptor potential cation channel subfamily M member 7

    See identical proteins and their annotated locations for NP_001025232.1

    Status: PROVISIONAL

    Source sequence(s)
    AY860421
    UniProtKB/TrEMBL
    Q563W7
    Related
    ENSDARP00000145809.1, ENSDART00000188914.1
    Conserved Domains (3) summary
    smart00811
    Location:15071725
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:8681086
    Ion_trans; Ion transport protein
    pfam16519
    Location:11791230
    TRPM_tetra; Tetramerization domain of TRPM

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    113845..150663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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