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    castor1 cytosolic arginine sensor for mTORC1 subunit 1 [ Danio rerio (zebrafish) ]

    Gene ID: 449937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    castor1provided by ZNC
    Official Full Name
    cytosolic arginine sensor for mTORC1 subunit 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-38
    See related
    Ensembl:ENSDARG00000079588 AllianceGenome:ZFIN:ZDB-GENE-050327-38
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gatsl3; im:7140101; zgc:110774
    Summary
    Predicted to be located in cytosol. Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See castor1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (11982547..12031124, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (11485203..11530794, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ring finger protein, transmembrane 2 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene oncostatin M Neighboring gene nipsnap homolog 1 (C. elegans) Neighboring gene leucine rich repeat containing 74B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. Tucker SK, et al. Development, 2024 Mar 15. PMID 38512806,
    2. Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Mahony CB, et al. Stem Cell Reports, 2018 Jun 5. PMID 29779898, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables arginine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic arginine sensor for mTORC1 subunit 1
    Names
    GATS protein-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020815.2 → NP_001018651.2  cytosolic arginine sensor for mTORC1 subunit 1

      Status: VALIDATED

      Source sequence(s)
      CR933780, CU571177, CU571331
      UniProtKB/TrEMBL
      Q58ER9
      Related
      ENSDART00000110991.5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      11982547..12031124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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