otud5a OTU deubiquitinase 5a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: otud5aprovided by ZNC
Official Full Name: OTU deubiquitinase 5aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-61
See related: Ensembl:ENSDARG00000059006 AllianceGenome:ZFIN:ZDB-GENE-030616-61
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DUBA; otud5; zgc:154072; si:bz30i22.1; si:rp71-30i22.1
Summary: Predicted to enable K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of TOR signaling; and protein deubiquitination. Predicted to act upstream of or within proteolysis. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (8860927..8922631)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (8822342..8884046)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: OTU domain-containing protein 5-A

Names: OTU domain containing 5; OTU domain containing 5a; OTU domain-containing protein 5; deubiquitinating enzyme A

NP_001068578.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.