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    ZNF333 zinc finger protein 333 [ Homo sapiens (human) ]

    Gene ID: 84449, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF333provided by HGNC
    Official Full Name
    zinc finger protein 333provided by HGNC
    Primary source
    HGNC:HGNC:15624
    See related
    Ensembl:ENSG00000160961 MIM:611811; AllianceGenome:HGNC:15624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in appendix (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF333 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14689787..14733742)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14816091..14860049)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14800860..14844554)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene YPEL5 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 333 (ZNF333) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • KIAA1806

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300912.2NP_001287841.1  zinc finger protein 333 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC090427, AF372702, BC048107, DA103403
      Consensus CDS
      CCDS74298.1
      UniProtKB/Swiss-Prot
      Q96JL9
      Related
      ENSP00000438130.1, ENST00000540689.6
      Conserved Domains (2) summary
      smart00349
      Location:203263
      KRAB; krueppel associated box
      pfam01352
      Location:203242
      KRAB; KRAB box
    2. NM_001352239.2NP_001339168.1  zinc finger protein 333 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, BP231733, DA103403, HY032449
      UniProtKB/TrEMBL
      B3KSN8
      Conserved Domains (5) summary
      smart00349
      Location:94154
      KRAB; krueppel associated box
      COG5048
      Location:119416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:509531
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440463
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001352240.2NP_001339169.1  zinc finger protein 333 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, BP231733, DA103403, DC335178, HY032449
      UniProtKB/TrEMBL
      B3KSN8
      Conserved Domains (5) summary
      smart00349
      Location:94154
      KRAB; krueppel associated box
      COG5048
      Location:119416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:509531
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440463
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001352241.2NP_001339170.1  zinc finger protein 333 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, DA103403, DA248936
      Conserved Domains (4) summary
      smart00349
      Location:57117
      KRAB; krueppel associated box
      COG5048
      Location:211379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:278298
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:403426
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001352243.2NP_001339172.1  zinc finger protein 333 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, DA103403
      Conserved Domains (4) summary
      COG5048
      Location:126294
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:318341
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    6. NM_001352244.2NP_001339173.1  zinc finger protein 333 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, DA103403
      Conserved Domains (1) summary
      smart00349
      Location:203263
      KRAB; krueppel associated box
    7. NM_032433.4NP_115809.1  zinc finger protein 333 isoform 1

      See identical proteins and their annotated locations for NP_115809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC090427, AF372702, DA103403
      Consensus CDS
      CCDS12316.1
      UniProtKB/Swiss-Prot
      Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
      Related
      ENSP00000292530.5, ENST00000292530.11
      Conserved Domains (6) summary
      smart00349
      Location:203263
      KRAB; krueppel associated box
      COG5048
      Location:228525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394416
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:203242
      KRAB; KRAB box
      pfam13465
      Location:408433
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      14689787..14733742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528362.3XP_011526664.1  zinc finger protein 333 isoform X1

      See identical proteins and their annotated locations for XP_011526664.1

      UniProtKB/Swiss-Prot
      Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
      Conserved Domains (6) summary
      smart00349
      Location:203263
      KRAB; krueppel associated box
      COG5048
      Location:228525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394416
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:203242
      KRAB; KRAB box
      pfam13465
      Location:408433
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047439519.1XP_047295475.1  zinc finger protein 333 isoform X2

      UniProtKB/TrEMBL
      B3KSN8
    3. XM_047439518.1XP_047295474.1  zinc finger protein 333 isoform X2

      UniProtKB/TrEMBL
      B3KSN8
    4. XM_011528371.3XP_011526673.1  zinc finger protein 333 isoform X3

      Conserved Domains (6) summary
      smart00349
      Location:1474
      KRAB; krueppel associated box
      COG5048
      Location:168336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:235255
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:205227
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:219244
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      14816091..14860049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322348.1XP_054178323.1  zinc finger protein 333 isoform X1

      UniProtKB/Swiss-Prot
      Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
    2. XM_054322349.1XP_054178324.1  zinc finger protein 333 isoform X2

      UniProtKB/TrEMBL
      B3KSN8
    3. XM_054322350.1XP_054178325.1  zinc finger protein 333 isoform X3

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