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Conserved domains on  [gi|1203190010|ref|NP_001339172|]
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zinc finger protein 333 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-294 5.02e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 126 EKIRSGDKSYACNKCEKSFRYSSDLIRHEKT--HTAEK----CFDCQECGQAFKYSSNLRRHMRTHTGEKPFEC--SQCG 197
Cdd:COG5048   281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkpfSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSS 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 198 KTFTRNFN-----LILHQRNHTGEKPYEC--KDCGKAFNQPSSLRSHVRTHTGEKP--FECSQCGKAFREHSSLKTHLRT 268
Cdd:COG5048   361 SKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKI 440

                         170       180
                  ....*....|....*....|....*.
gi 1203190010 269 HTREKPYECNQCGKPFRTSTHLNVHK 294
Cdd:COG5048   441 HTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB super family cl42959
krueppel associated box;
1-32 6.20e-07

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 46.43  E-value: 6.20e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1203190010    1 MLENYRNLASVADQLCKPNALSYLEERGEQWT 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-341 7.70e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.70e-05
                          10        20
                  ....*....|....*....|....
gi 1203190010 318 LKSHMRTHTGEKPYVCQECGRAFS 341
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-368 3.05e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|....
gi 1203190010 345 SLRKHARTHSGKKPYACQECGRAF 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 387-409 8.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 8.95e-03
                          10        20
                  ....*....|....*....|...
gi 1203190010 387 YQCNQCEKAFRHSSSLTVHKRTH 409
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-294 5.02e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 126 EKIRSGDKSYACNKCEKSFRYSSDLIRHEKT--HTAEK----CFDCQECGQAFKYSSNLRRHMRTHTGEKPFEC--SQCG 197
Cdd:COG5048   281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkpfSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSS 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 198 KTFTRNFN-----LILHQRNHTGEKPYEC--KDCGKAFNQPSSLRSHVRTHTGEKP--FECSQCGKAFREHSSLKTHLRT 268
Cdd:COG5048   361 SKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKI 440

                         170       180
                  ....*....|....*....|....*.
gi 1203190010 269 HTREKPYECNQCGKPFRTSTHLNVHK 294
Cdd:COG5048   441 HTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 6.20e-07

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 46.43  E-value: 6.20e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1203190010    1 MLENYRNLASVADQLCKPNALSYLEERGEQWT 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-202 1.61e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.61e-06
                          10        20
                  ....*....|....*....|....*.
gi 1203190010 177 NLRRHMRTHTGEKPFECSQCGKTFTR 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-341 7.70e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.70e-05
                          10        20
                  ....*....|....*....|....
gi 1203190010 318 LKSHMRTHTGEKPYVCQECGRAFS 341
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-368 3.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|....
gi 1203190010 345 SLRKHARTHSGKKPYACQECGRAF 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 387-409 8.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 8.95e-03
                          10        20
                  ....*....|....*....|...
gi 1203190010 387 YQCNQCEKAFRHSSSLTVHKRTH 409
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-294 5.02e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 126 EKIRSGDKSYACNKCEKSFRYSSDLIRHEKT--HTAEK----CFDCQECGQAFKYSSNLRRHMRTHTGEKPFEC--SQCG 197
Cdd:COG5048   281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkpfSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSS 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 198 KTFTRNFN-----LILHQRNHTGEKPYEC--KDCGKAFNQPSSLRSHVRTHTGEKP--FECSQCGKAFREHSSLKTHLRT 268
Cdd:COG5048   361 SKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKI 440

                         170       180
                  ....*....|....*....|....*.
gi 1203190010 269 HTREKPYECNQCGKPFRTSTHLNVHK 294
Cdd:COG5048   441 HTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 6.20e-07

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 46.43  E-value: 6.20e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1203190010    1 MLENYRNLASVADQLCKPNALSYLEERGEQWT 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-349 1.30e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 105 ASCECQEIRNSFFQSAHLIVPEKIRSGDKSYACNK-CEKSF--RYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRH 181
Cdd:COG5048   200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlSPKSLlsQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 182 MRTHTG-EKPFECSQCGKTFTRNFNLILHQR--NHTGE--KPYEC--KDCGKAFNQPSSLRSHVRTHTGEKPFEC--SQC 252
Cdd:COG5048   280 SSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNS 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 253 GKAFREHSSLKTHLRTHTR-----EKPYEC--NQCGKPFRTSTHLNVHKRIHTGEKLYEC--ATCGQVLSRLSTLKSHMR 323
Cdd:COG5048   360 SSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKK 439

                         250       260
                  ....*....|....*....|....*.
gi 1203190010 324 THTgEKPYVCQECGRAFSEPSSLRKH 349
Cdd:COG5048   440 IHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-202 1.61e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 1.61e-06
                          10        20
                  ....*....|....*....|....*.
gi 1203190010 177 NLRRHMRTHTGEKPFECSQCGKTFTR 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-427 3.64e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 132 DKSYACNKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYS--SNLRRHMRTHTGEKPFECSQC------------- 196
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSlplsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 197 -GKTFTRNFNLILHQRNHTGEKPY---------------ECKDC-GKAFNQPSSLRSHVRTHTGEKPFECSqcgkafrEH 259
Cdd:COG5048   111 sSSSSNSNDNNLLSSHSLPPSSRDpqlpdllsisnlrnnPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPS-------SN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 260 SSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEKPYVCQECGRA 339
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 340 ------FSEPSSLRKHARTHSGK-KPYACQECGRAFGQSSHLIVHVRTHSA----GRPYQC--NQCEKAFRHSSSLTVHK 406
Cdd:COG5048   264 slptasSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHsgesLKPFSCpySLCGKLFSRNDALKRHI 343

                         330       340
                  ....*....|....*....|.
gi 1203190010 407 RTHVGRETIRNGSLPLSMSHP 427
Cdd:COG5048   344 LLHTSISPAKEKLLNSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-256 7.55e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.55e-05
                          10        20
                  ....*....|....*....|....
gi 1203190010 233 SLRSHVRTHTGEKPFECSQCGKAF 256
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-341 7.70e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.70e-05
                          10        20
                  ....*....|....*....|....
gi 1203190010 318 LKSHMRTHTGEKPYVCQECGRAFS 341
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-230 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 1203190010 205 NLILHQRNHTGEKPYECKDCGKAFNQ 230
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-408 4.20e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 159 AEKCFDCQECGQAFKYSSNLRRHMRTHTGEKPFECSQ--CGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRS 236
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 237 HVRTHTGEKPFE-CSQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTS----------------------THLNVH 293
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 294 KRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEKPYVCQECGRAF------SEPSSLRKHARTHSGKKPYACQECGRA 367
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1203190010 368 FGQSSHLIVHVRTHSA-GRPYQCNQCEKAFRHSSSLTVHKRT 408
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRS 311
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 163-185 1.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|...
gi 1203190010 163 FDCQECGQAFKYSSNLRRHMRTH 185
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 219-241 2.09e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|...
gi 1203190010 219 YECKDCGKAFNQPSSLRSHVRTH 241
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 187-270 2.69e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1203190010 187 GEKPFECS--QCGKTFTRNFNLILHQRN-HTGEKPYECKDcgkafnqPSSLRSHVrthTGEKPFECSQCGKAFREHSSLK 263
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPS-------PEKMNIFS---AKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1203190010 264 THlRTHT 270
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-368 3.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.05e-03
                          10        20
                  ....*....|....*....|....
gi 1203190010 345 SLRKHARTHSGKKPYACQECGRAF 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-282 5.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.61e-03
                          10        20
                  ....*....|....*....|..
gi 1203190010 261 SLKTHLRTHTREKPYECNQCGK 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 191-213 8.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.36e-03
                          10        20
                  ....*....|....*....|...
gi 1203190010 191 FECSQCGKTFTRNFNLILHQRNH 213
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 387-409 8.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 8.95e-03
                          10        20
                  ....*....|....*....|...
gi 1203190010 387 YQCNQCEKAFRHSSSLTVHKRTH 409
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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