ddx-19 RNA helicase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ddx-19
Official Full Name: RNA helicase
Primary source: WormBase:WBGene00011580
Locus tag: CELE_T07D4.4
See related: AllianceGenome:WB:WBGene00011580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Involved in germ cell development. Located in P granule. Is expressed in excretory cell; hypodermis; and tail. Orthologous to several human genes including DDX19A (DEAD-box helicase 19A) and DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddx-19 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 14

Sequence:: Chromosome: II; NC_003280.10 (8884899..8889702)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07D4.4 (e-PCR)
- UniSTS:317528

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA helicase

NP_001254186.1

Confirmed by transcript evidence

NP_001293467.1

Confirmed by transcript evidence

NP_495891.1

Confirmed by transcript evidence

NP_495892.1

Confirmed by transcript evidence

NP_495893.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8884899..8889702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063492.2 → NP_495893.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495893.1

Status: REVIEWED

UniProtKB/TrEMBL

O62372

Conserved Domains (3) summary

PTZ00424
Location:208 → 599

PTZ00424; helicase 45; Provisional

cd00079
Location:428 → 575

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cl21455
Location:211 → 415

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_063490.5 → NP_495891.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495891.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22308

Conserved Domains (4) summary

PTZ00424
Location:617 → 1016

PTZ00424; helicase 45; Provisional

cd00079
Location:837 → 984

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam13634
Location:158 → 247

Nucleoporin_FG; Nucleoporin FG repeat region

cl21455
Location:620 → 824

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_063491.6 → NP_495892.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495892.1

Status: REVIEWED

UniProtKB/TrEMBL

O18056, Q22309

Conserved Domains (3) summary

PTZ00424
Location:233 → 624

PTZ00424; helicase 45; Provisional

cd00079
Location:453 → 600

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cl21455
Location:236 → 440

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001267257.3 → NP_001254186.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254186.1

Status: REVIEWED

UniProtKB/TrEMBL

B7WN80

Conserved Domains (3) summary

PTZ00424
Location:202 → 593

PTZ00424; helicase 45; Provisional

cd00079
Location:422 → 569

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cl21455
Location:205 → 409

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001306538.4 → NP_001293467.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293467.1

Status: REVIEWED

UniProtKB/TrEMBL

B7WN81

Conserved Domains (3) summary

PTZ00424
Location:92 → 483

PTZ00424; helicase 45; Provisional

cd00079
Location:312 → 459

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cl21455
Location:95 → 299

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases