|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
617-1022 |
1.29e-106 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 338.66 E-value: 1.29e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 617 ISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLM-CPQCICLA 695
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAG--RDVLGQAQTGTGKTAAFLLPLLQRLDPSRPrAPQALILA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 696 PTLELAKQIGEVVEKMGKFIdNLKIHYAIKGGNMAAMRgRKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEAD 773
Cdd:COG0513 79 PTRELALQVAEELRKLAKYL-GLRVATVYGGVSIGRQI-RALKRgvDIVVATPGRLLDLIER-GALDLSGVETLVLDEAD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 774 VMIyHQGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQFYVQCAcRDSKYA 853
Cdd:COG0513 156 RML-DMGFIE---DIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVD-KRDKLE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 854 AIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQV 933
Cdd:COG0513 231 LLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 934 SVVINYDLPikytdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAINLIDSEDsMNMINVLENHFQMKIARMDPSNL 1013
Cdd:COG0513 311 SHVINYDLP-----------------EDPEDYVHRIGRTGRAGAEGTAISLVTPDE-RRLLRAIEKLIGQKIEEEELPGF 372
|
....*....
gi 17536103 1014 VELEAIEMA 1022
Cdd:COG0513 373 EPVEEKRLE 381
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
625-827 |
1.58e-104 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 324.53 E-value: 1.58e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 625 LKPEVLKALDTMNFQFPTRIQETALPLLLMEPPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQI 704
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 705 GEVVEKMGKFiDNLKIHYAIKGGNMAamRGRKLTEQIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIYHQGFTDI 784
Cdd:cd17963 81 GEVVEKMGKF-TGVKVALAVPGNDVP--RGKKITAQIVIGTPGTVLDWLKK-RQLDLKKIKILVLDEADVMLDTQGHGDQ 156
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 17536103 785 STTIYNMVEdasDSVQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:cd17963 157 SIRIKRMLP---RNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
603-832 |
5.35e-80 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 259.95 E-value: 5.35e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 603 VDVQRQDPKSPLYSISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEPPSNLIAQAQSGTGKTAAFVLTMLCRI 682
Cdd:cd18048 3 VEVLQRDPTSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADPPQNLIAQSQSGTGKTAAFVLAMLSRV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 683 DVNLMCPQCICLAPTLELAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAamRGRKLTEQIVIGTPGITRDYLQKYKCIDPS 762
Cdd:cd18048 83 DALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPG--KGTDIEAQIVIGTPGTVLDWCFKLRLIDVT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 763 KIRCLVLDEADVMIYHQGFTDISTTIYNMVedaSDSVQSMLFSATYDEPVINFATKIIKNAIVVMLKREE 832
Cdd:cd18048 161 NISVFVLDEADVMINVQGHSDHSVRVKRSM---PKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEE 227
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
617-1016 |
8.44e-80 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 265.92 E-value: 8.44e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 617 ISSFRELRLKPEVLKALDTMNFQFPTRIQETAL-PLLlmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLA 695
Cdd:PTZ00424 27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIkPIL---DGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 696 PTLELAKQIGEVVEKMGKFIDnLKIHyAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEAD 773
Cdd:PTZ00424 104 PTRELAQQIQKVVLALGDYLK-VRCH-ACVGGTVVRDDINKLKAgvHMVVGTPGRVYDMIDK-RHLRVDDLKLFILDEAD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 774 VMIyHQGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQFYVQCACRDSKYA 853
Cdd:PTZ00424 181 EML-SRGFKG---QIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFD 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 854 AIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQV 933
Cdd:PTZ00424 257 TLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQV 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 934 SVVINYDLPIkytdegTPmvvdgftqpdcETYLHRIGRTGRFGKTGIAINLIDSEDSMNMINVlENHFQMKIARMdPSNL 1013
Cdd:PTZ00424 337 SLVINYDLPA------SP-----------ENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI-ERHYNTQIEEM-PMEV 397
|
...
gi 17536103 1014 VEL 1016
Cdd:PTZ00424 398 ADY 400
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
616-1022 |
4.94e-76 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 257.42 E-value: 4.94e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 616 SISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLA 695
Cdd:PRK11776 2 SMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAG--KDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 696 PTLELAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAAMRGrKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEAD 773
Cdd:PRK11776 80 PTRELADQVAKEIRRLARFIPNIKVLTLCGGVPMGPQID-SLEHgaHIIVGTPGRILDHLRK-GTLDLDALNTLVLDEAD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 774 VMIyHQGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAivVMLKREEQ-ALPNIKQFYVQCAcRDSKY 852
Cdd:PRK11776 158 RML-DMGFQD---AIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDP--VEVKVESThDLPAIEQRFYEVS-PDERL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 853 AAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQ 932
Cdd:PRK11776 231 PALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 933 VSVVINYDLPikytdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAINLIdSEDSMNMINVLENHFQMKIAR----- 1007
Cdd:PRK11776 311 LEAVINYELA-----------------RDPEVHVHRIGRTGRAGSKGLALSLV-APEEMQRANAIEDYLGRKLNWeplps 372
|
410
....*....|....*
gi 17536103 1008 MDPSNLVELEAiEMA 1022
Cdd:PRK11776 373 LSPLSGVPLLP-EMV 386
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
619-826 |
1.27e-62 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 211.50 E-value: 1.27e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 619 SFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEPPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTL 698
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 699 ELAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAamRGRKLTEQIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADVMIYH 778
Cdd:cd18047 82 ELALQTGKVIEQMGKFYPELKLAYAVRGNKLE--RGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIAT 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 17536103 779 QGFTDISTTIYNMVEDAsdsVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd18047 160 QGHQDQSIRIQRMLPRN---CQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
620-989 |
7.47e-57 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 202.87 E-value: 7.47e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTML-------------CRIDVnl 686
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDG--RDVLGSAPTGTGKTAAFLLPALqhlldfprrksgpPRILI-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 687 mcpqcicLAPTLELAKQIGEVVEKMGKFIdNLKIhYAIKGGNMAAMRGRKLTEQ--IVIGTPGITRDYLQKYKcIDPSKI 764
Cdd:PRK11192 79 -------LTPTRELAMQVADQARELAKHT-HLDI-ATITGGVAYMNHAEVFSENqdIVVATPGRLLQYIKEEN-FDCRAV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 765 RCLVLDEADVMIyHQGFtdiSTTIYNMVEDASDSVQSMLFSATYD-EPVINFATKIIKNAIVVMLK--REEQAlpNIKQF 841
Cdd:PRK11192 149 ETLILDEADRML-DMGF---AQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEVEAEpsRRERK--KIHQW 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 842 YVQCACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITT 921
Cdd:PRK11192 223 YYRADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVAT 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17536103 922 NVFARGIDVAQVSVVINYDLPikYTdegtpmvvdgftqpdCETYLHRIGRTGRFGKTGIAINLIDSED 989
Cdd:PRK11192 303 DVAARGIDIDDVSHVINFDMP--RS---------------ADTYLHRIGRTGRAGRKGTAISLVEAHD 353
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
618-1012 |
3.23e-55 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 203.54 E-value: 3.23e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 618 SSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPT 697
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLL--NGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 698 LELAKQIGEVVEKMGKFIDNLKIhYAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLqKYKCIDPSKIRCLVLDEADVM 775
Cdd:PRK11634 84 RELAVQVAEAMTDFSKHMRGVNV-VALYGGQRYDVQLRALRQgpQIVVGTPGRLLDHL-KRGTLDLSKLSGLVLDEADEM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 776 IyHQGFTDISTTIYNMVEDASdsvQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQFY--VQCAcrdSKYA 853
Cdd:PRK11634 162 L-RMGFIEDVETIMAQIPEGH---QTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYwtVWGM---RKNE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 854 AIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQV 933
Cdd:PRK11634 235 ALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERI 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17536103 934 SVVINYDLPIkytdegtpmvvdgftqpDCETYLHRIGRTGRFGKTGIAINLIDSEDSMNMINVlENHFQMKIARMDPSN 1012
Cdd:PRK11634 315 SLVVNYDIPM-----------------DSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNI-ERTMKLTIPEVELPN 375
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
620-993 |
9.23e-48 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 176.32 E-value: 9.23e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmepPSNLIA-QAQSGTGKTAAF-------VLTMLCRIDVNLMCPQC 691
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTL---AGRDVAgQAQTGTGKTMAFltatfhyLLSHPAPEDRKVNQPRA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 692 ICLAPTLELAKQIGEVVEKMGKfIDNLKIhyAIKGGNMAAMRGRKLTEQ---IVIGTPGITRDYLqKYKCIDPSKIRCLV 768
Cdd:PRK04837 87 LIMAPTRELAVQIHADAEPLAQ-ATGLKL--GLAYGGDGYDKQLKVLESgvdILIGTTGRLIDYA-KQNHINLGAIQVVV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 769 LDEADVMiYHQGF-TDISTTIYNMvEDASDSVqSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQ--FYvqc 845
Cdd:PRK04837 163 LDEADRM-FDLGFiKDIRWLFRRM-PPANQRL-NMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEelFY--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 846 ACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFA 925
Cdd:PRK04837 237 PSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17536103 926 RGIDVAQVSVVINYDLPikytdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAINLIDSEDSMNM 993
Cdd:PRK04837 317 RGLHIPAVTHVFNYDLP-----------------DDCEDYVHRIGRTGRAGASGHSISLACEEYALNL 367
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
629-826 |
1.05e-47 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 168.77 E-value: 1.05e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC----PQCICLAPTLELAKQI 704
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSG--RDVIGQAQTGSGKTLAFLLPILEKLLPEPKKkgrgPQALVLAPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 705 GEVVEKMGKFiDNLKIHyAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMIyHQGFT 782
Cdd:cd00268 79 AEVARKLGKG-TGLKVA-AIYGGAPIKKQIEALKKgpDIVVGTPGRLLDLIERGK-LDLSNVKYLVLDEADRML-DMGFE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 17536103 783 DISTTIYNMVedaSDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd00268 155 EDVEKILSAL---PKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
838-985 |
1.46e-47 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 165.76 E-value: 1.46e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 838 IKQFYVQCACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKV 917
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17536103 918 LITTNVFARGIDVAQVSVVINYDLPikytdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAINLI 985
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLP-----------------RDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
613-1005 |
2.99e-44 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 169.75 E-value: 2.99e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 613 PLYSISsFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRI-------DVN 685
Cdd:PRK04537 5 PLTDLT-FSSFDLHPALLAGLESAGFTRCTPIQALTLPVAL--PGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpalaDRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 686 LMCPQCICLAPTLELAKQIGEVVEKMGKfidNLKIHYAIKGGNMAAMRGRKLTEQ---IVIGTPGITRDYLQKYKCIDPS 762
Cdd:PRK04537 82 PEDPRALILAPTRELAIQIHKDAVKFGA---DLGLRFALVYGGVDYDKQRELLQQgvdVIIATPGRLIDYVKQHKVVSLH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 763 KIRCLVLDEADVMiYHQGF-TDISTTIYNMVEDASDsvQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQf 841
Cdd:PRK04537 159 ACEICVLDEADRM-FDLGFiKDIRFLLRRMPERGTR--QTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQ- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 842 YVQCACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITT 921
Cdd:PRK04537 235 RIYFPADEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVAT 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 922 NVFARGIDVAQVSVVINYDLPIkytdegtpmvvdgftqpDCETYLHRIGRTGRFGKTGIAINLIDSEDSMNMINVlENHF 1001
Cdd:PRK04537 315 DVAARGLHIDGVKYVYNYDLPF-----------------DAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDI-EAYI 376
|
....
gi 17536103 1002 QMKI 1005
Cdd:PRK04537 377 EQKI 380
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
527-990 |
3.14e-44 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 167.40 E-value: 3.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 527 GRGRGQQNPAFVPRPRDTPPqygghqAAQQFVKPDSKYKFTKPATEEAHEQVPVPADIALLNKFIQKEVKMMKDVVVDvq 606
Cdd:PRK01297 10 GKGEAEQPAPAPPSPAAAPA------PPPPAKTAAPATKAAAPAAAAPRAEKPKKDKPRRERKPKPASLWKLEDFVVE-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 607 rqdpksPLYSISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVN- 685
Cdd:PRK01297 82 ------PQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAG--HDAIGRAQTGTGKTAAFLISIINQLLQTp 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 686 ------LMCPQCICLAPTLELAKQIGEVVEKMGKFIDnlkIHYAIKGGNMAAMRGRKLTEQ----IVIGTPGITRDYLQK 755
Cdd:PRK01297 154 ppkeryMGEPRALIIAPTRELVVQIAKDAAALTKYTG---LNVMTFVGGMDFDKQLKQLEArfcdILVATPGRLLDFNQR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 756 yKCIDPSKIRCLVLDEADVMIyHQGFTDISTTIYNMVEDASDSvQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQAL 835
Cdd:PRK01297 231 -GEVHLDMVEVMVLDEADRML-DMGFIPQVRQIIRQTPRKEER-QTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVAS 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 836 PNIKQFYVQCACRDsKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDF 915
Cdd:PRK01297 308 DTVEQHVYAVAGSD-KYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKI 386
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536103 916 KVLITTNVFARGIDVAQVSVVINYDLPikytdegtpmvvdgfTQPDceTYLHRIGRTGRFGKTGIAINLIDSEDS 990
Cdd:PRK01297 387 RVLVATDVAGRGIHIDGISHVINFTLP---------------EDPD--DYVHRIGRTGRAGASGVSISFAGEDDA 444
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
619-1011 |
4.32e-42 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 160.74 E-value: 4.32e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 619 SFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQ------CI 692
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVL--EGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 693 CLAPTLELAKQIGEVVEKMGKFIDNLKIhyAIKGG-----NMAAMRGrklTEQIVIGTPGITRDyLQKYKCIDPSKIRCL 767
Cdd:PRK10590 80 ILTPTRELAAQIGENVRDYSKYLNIRSL--VVFGGvsinpQMMKLRG---GVDVLVATPGRLLD-LEHQNAVKLDQVEIL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 768 VLDEADVMIyHQGFT-DISTTIYNMvedaSDSVQSMLFSATYDEPVINFATKIIKNAIVVMLKREEQALPNIKQFyVQCA 846
Cdd:PRK10590 154 VLDEADRML-DMGFIhDIRRVLAKL----PAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQH-VHFV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 847 CRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFAR 926
Cdd:PRK10590 228 DKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAAR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 927 GIDVAQVSVVINYDLPikytdeGTPmvvdgftqpdcETYLHRIGRTGRFGKTGIAINLIdSEDSMNMINVLENHFQMKIA 1006
Cdd:PRK10590 308 GLDIEELPHVVNYELP------NVP-----------EDYVHRIGRTGRAAATGEALSLV-CVDEHKLLRDIEKLLKKEIP 369
|
410
....*....|..
gi 17536103 1007 RM-------DPS 1011
Cdd:PRK10590 370 RIaipgyepDPS 381
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
642-815 |
8.70e-41 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 147.77 E-value: 8.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 642 TRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEVVEKMGKFIDnLKIH 721
Cdd:pfam00270 1 TPIQAEAIPAILEG--RDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLG-LKVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 722 YAIKGGNMAAMRGRKLTEQIVIGTPGITRDYLQKYKCIdpSKIRCLVLDEADVMIYhQGFTDIsttIYNMVEDASDSVQS 801
Cdd:pfam00270 78 SLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLLD-MGFGPD---LEEILRRLPKKRQI 151
|
170
....*....|....
gi 17536103 802 MLFSATYDEPVINF 815
Cdd:pfam00270 152 LLLSATLPRNLEDL 165
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
620-827 |
3.18e-38 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 141.81 E-value: 3.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETA-LPLLLmepPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTL 698
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAiMPCIK---GYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 699 ELAKQIGEVVEKMGKFIdNLKIHYAIKGGNMAA-MRGRKLTEQIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIy 777
Cdd:cd18046 78 ELAQQIQKVVMALGDYM-GIKCHACIGGTSVRDdAQKLQAGPHIVVGTPGRVFDMINR-RYLRTDYIKMFVLDEADEML- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 17536103 778 HQGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:cd18046 155 SRGFKD---QIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
593-981 |
1.04e-35 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 143.38 E-value: 1.04e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 593 KEVKMMKDVVVDVQRQDPKSplysISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTA 672
Cdd:PTZ00110 109 DEIRKEKEITIIAGENVPKP----VVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIAL--SGRDMIGIAETGSGKTL 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 673 AFVLTMLCRIDVNLMC-----PQCICLAPTLELAKQIGEVVEKMGKfidNLKIHYAI------KGGNMAAMRGrklTEQI 741
Cdd:PTZ00110 183 AFLLPAIVHINAQPLLrygdgPIVLVLAPTRELAEQIREQCNKFGA---SSKIRNTVayggvpKRGQIYALRR---GVEI 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 742 VIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIyHQGFtdiSTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIK 821
Cdd:PTZ00110 257 LIACPGRLIDFLES-NVTNLRRVTYLVLDEADRML-DMGF---EPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCK 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 822 NAIV------VMLKreeqALPNIKQfYVQCACRDSKYAAIVNLYSGLAVASS--VIFCHTKASVMWLYENMRARGHQVDV 893
Cdd:PTZ00110 332 EEPVhvnvgsLDLT----ACHNIKQ-EVFVVEEHEKRGKLKMLLQRIMRDGDkiLIFVETKKGADFLTKELRLDGWPALC 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 894 LHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPIKYTDegtpmvvdgftqpdcetYLHRIGRTG 973
Cdd:PTZ00110 407 IHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIED-----------------YVHRIGRTG 469
|
....*...
gi 17536103 974 RFGKTGIA 981
Cdd:PTZ00110 470 RAGAKGAS 477
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
622-824 |
1.42e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 133.99 E-value: 1.42e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 622 ELRLKPEVLKALDTMNFQFPTRIQETA-LPLLLMEppsNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLEL 700
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAiVPIIKGR---DVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 701 AKQIGEVVEKMGKFIdNLKIHYAIKGGNMAAMRgRKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIyH 778
Cdd:cd17939 78 AQQIQKVVKALGDYM-GVKVHACIGGTSVREDR-RKLQYgpHIVVGTPGRVFDMLQR-RSLRTDKIKMFVLDEADEML-S 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 17536103 779 QGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAI 824
Cdd:cd17939 154 RGFKD---QIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
629-827 |
2.13e-35 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 133.16 E-value: 2.13e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEVV 708
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAG--HDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 709 EKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQIVIGTPGITRdYLQKYKCIDPSKIRCLVLDEADvMIYHQGFTDISTTI 788
Cdd:cd17943 79 KKIGKKLEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIK-QLIELGALNVSHVRLFVLDEAD-KLMEGSFQKDVNWI 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 17536103 789 YNMVedaSDSVQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:cd17943 157 FSSL---PKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
620-826 |
8.50e-35 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 131.65 E-value: 8.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLE 699
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSG--RDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFIdNLKIHYAIKGGNMA--AMRGRKlTEQIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIy 777
Cdd:cd17940 79 LALQTSQVCKELGKHM-GVKVMVTTGGTSLRddIMRLYQ-TVHVLVGTPGRILDLAKK-GVADLSHCKTLVLDEADKLL- 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 17536103 778 HQGFTDISTTIYNMvedASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17940 155 SQDFQPIIEKILNF---LPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
633-841 |
1.07e-32 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 125.68 E-value: 1.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 633 LDTMNFQFPTRIQETALPLLLMEPpSNLIAQAQSGTGKTAAFVLTMLCRIDvNLMCPQCICLAPTLELAKQIGEVVEKMG 712
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTLAALLPALEALK-RGKGGRVLVLVPTRELAEQWAEELKKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 713 KFIDNLKIhyAIKGGNMAAMRGRKLTE---QIVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMIYhQGFTDIsttIY 789
Cdd:smart00487 79 PSLGLKVV--GLYGGDSKREQLRKLESgktDILVTTPGRLLDLLENDK-LSLSNVDLVILDEAHRLLD-GGFGDQ---LE 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 17536103 790 NMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVVMLKREeqALPNIKQF 841
Cdd:smart00487 152 KLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFT--PLEPIEQF 201
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
625-821 |
5.08e-32 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 124.23 E-value: 5.08e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 625 LKPEVLKALDTMNFQFPTRIQETALPLLLmEPPSNLIAQAQSGTGKTAAFVLTML-CRIDVNLMCPQ----CICLAPTLE 699
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPIL-STGDDVLARAKTGTGKTLAFLLPAIqSLLNTKPAGRRsgvsALIISPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAA--MRGRKLTEQIVIGTPGITRDYLQKYKCIDP-SKIRCLVLDEADVMI 776
Cdd:cd17964 80 LALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAelNRLRRGRPDILVATPGRLIDHLENPGVAKAfTDLDYLVLDEADRLL 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 17536103 777 yHQGF-TDISTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIK 821
Cdd:cd17964 160 -DMGFrPDLEQILRHLPEKNADPRQTLLFSATVPDEVQQIARLTLK 204
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
603-989 |
5.77e-32 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 131.83 E-value: 5.77e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 603 VDVQRQDPKSPlysISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRi 682
Cdd:PLN00206 109 IHVKGEAVPPP---ILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSG--RSLLVSADTGSGKTASFLVPIISR- 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 683 dvnlmC-------------PQCICLAPTLELAKQIGEVVEKMGKFIDnLKIHYAIKGGNMAAM--RGRKLTEQIViGTPG 747
Cdd:PLN00206 183 -----CctirsghpseqrnPLAMVLTPTRELCVQVEDQAKVLGKGLP-FKTALVVGGDAMPQQlyRIQQGVELIV-GTPG 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 748 ITRDYLQKYKcIDPSKIRCLVLDEADVMIyHQGFTDISTTIYNmvedASDSVQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:PLN00206 256 RLIDLLSKHD-IELDNVSVLVLDEVDCML-ERGFRDQVMQIFQ----ALSQPQVLLFSATVSPEVEKFASSLAKDIILIS 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 828 LKREEQALPNIKQFYVQCACRDSKYAAIVNLYSGLAV-ASSVIFCHTKASVMWLYENMR-ARGHQVDVLHGDMTVVERAD 905
Cdd:PLN00206 330 IGNPNRPNKAVKQLAIWVETKQKKQKLFDILKSKQHFkPPAVVFVSSRLGADLLANAITvVTGLKALSIHGEKSMKERRE 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 906 TIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPikytdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAINLI 985
Cdd:PLN00206 410 VMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMP-----------------NTIKEYIHQIGRASRMGEKGTAIVFV 472
|
....
gi 17536103 986 DSED 989
Cdd:PLN00206 473 NEED 476
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
620-827 |
3.39e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 121.42 E-value: 3.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETAL-PLLlmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTL 698
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIkPII---KGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 699 ELAKQIGEVVEKMGKFIdNLKIHYAIkGGNMAAMRGRKLT--EQIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMI 776
Cdd:cd18045 78 ELAVQIQKVLLALGDYM-NVQCHACI-GGTSVGDDIRKLDygQHIVSGTPGRVFDMIRR-RSLRTRHIKMLVLDEADEML 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 17536103 777 yHQGFTDISTTIYNMVEDASdsvQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:cd18045 155 -NKGFKEQIYDVYRYLPPAT---QVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
618-822 |
5.10e-29 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 115.52 E-value: 5.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 618 SSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPT 697
Cdd:cd17950 2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILG--MDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 698 LELAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAAMRG--RKLTEQIVIGTPGITRDyLQKYKCIDPSKIRCLVLDEADVM 775
Cdd:cd17950 80 RELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEvlKNKCPHIVVGTPGRILA-LVREKKLKLSHVKHFVLDECDKM 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 17536103 776 IyhqgfTDIsttiyNMVEDASDSV-------QSMLFSATYDEPVINFATKIIKN 822
Cdd:cd17950 159 L-----EQL-----DMRRDVQEIFratphdkQVMMFSATLSKEIRPVCKKFMQD 202
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
619-807 |
5.79e-29 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 115.11 E-value: 5.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 619 SFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIdvnLMCPQ---CICLA 695
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQG--RDIIGLAETGSGKTAAFALPILQAL---LENPQrffALVLA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 696 PTLELAKQIGEVVEKMGKFIdNLKIHYAIKGGNMAAmRGRKLTEQ--IVIGTPGITRDYLQKYKCIDPSKIRCLVLDEAD 773
Cdd:cd17954 76 PTRELAQQISEQFEALGSSI-GLKSAVLVGGMDMMA-QAIALAKKphVIVATPGRLVDHLENTKGFSLKSLKFLVMDEAD 153
|
170 180 190
....*....|....*....|....*....|....
gi 17536103 774 VMIYhqgfTDISTTIYNMVEDASDSVQSMLFSAT 807
Cdd:cd17954 154 RLLN----MDFEPEIDKILKVIPRERTTYLFSAT 183
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
620-826 |
1.09e-28 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 114.34 E-value: 1.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIdvnlmcpQCICLAPTLE 699
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLIL--GGGDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQ---IVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMI 776
Cdd:cd17938 72 LAEQTYNCIENFKKYLDNPKLRVALLIGGVKAREQLKRLESgvdIVVGTPGRLEDLIKTGK-LDLSSVRFFVLDEADRLL 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 17536103 777 yHQGFTDISTTIYN-MVEDASDS--VQSMLFSATYDEP-VINFATKIIKNAIVV 826
Cdd:cd17938 151 -SQGNLETINRIYNrIPKITSDGkrLQVIVCSATLHSFeVKKLADKIMHFPTWV 203
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
629-827 |
5.14e-28 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 111.96 E-value: 5.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRI---DVNLMCPQCICLAPTLELAKQIG 705
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLG--KDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQCF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 706 EVVEKMGKFIDnLKIHYAIKGGNM----AAMRGRKlteQIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADVMIyHQGF 781
Cdd:cd17947 79 SVLQQLAQFTD-ITFALAVGGLSLkaqeAALRARP---DIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRML-EEGF 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 17536103 782 TDISTTIYNMVedaSDSVQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:cd17947 154 ADELKEILRLC---PRTRQTMLFSATMTDEVKDLAKLSLNKPVRVF 196
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
579-821 |
9.26e-27 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 110.83 E-value: 9.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 579 PVPADIALLNKFIQKEVKMMK--DVVVDVQRQDPKSPlysISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEp 656
Cdd:cd18052 5 PPPEDEDEIFATIQTGINFDKydEIPVEVTGRNPPPA---ILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAG- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 657 pSNLIAQAQSGTGKTAAF---VLTMLCRIDVNLMC------PQCICLAPTLELAKQIGEVVEkmgKFIDNLKIH-YAIKG 726
Cdd:cd18052 81 -RDLMACAQTGSGKTAAFllpVLTGMMKEGLTASSfsevqePQALIVAPTRELANQIFLEAR---KFSYGTCIRpVVVYG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 727 GNMAAMRGRKLTE--QIVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMIyHQGF-TDISTTIYNMVEDASDSVQSML 803
Cdd:cd18052 157 GVSVGHQIRQIEKgcHILVATPGRLLDFIGRGK-ISLSKLKYLILDEADRML-DMGFgPEIRKLVSEPGMPSKEDRQTLM 234
|
250
....*....|....*...
gi 17536103 804 FSATYDEPVINFATKIIK 821
Cdd:cd18052 235 FSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
636-826 |
3.35e-26 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 107.67 E-value: 3.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 636 MNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIdvNLMCPQ--------CICLAPTLELAKQIGEV 707
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQG--RDVLVRSQTGSGKTLAYLLPIIQRL--LSLEPRvdrsdgtlALVLVPTRELALQIYEV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 708 VEKMGKFIDNLKIHYAIKGGNMAA--MRGRK-LTeqIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADVMIyHQGFTDI 784
Cdd:cd17949 85 LEKLLKPFHWIVPGYLIGGEKRKSekARLRKgVN--ILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLL-DMGFEKD 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 17536103 785 STTIYNMVEDASDSV----------QSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17949 162 ITKILELLDDKRSKAggekskpsrrQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
850-976 |
9.95e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 102.29 E-value: 9.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 850 SKYAAIVNLYSGLAVASSVIFCHTKASVM--WLyenMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARG 927
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEaeLL---LEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERG 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 17536103 928 IDVAQVSVVINYDLPikytdegtpmvvdgftqPDCETYLHRIGRTGRFG 976
Cdd:pfam00271 78 LDLPDVDLVINYDLP-----------------WNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
629-827 |
1.02e-25 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 105.75 E-value: 1.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEPpsNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC--PQCICLAPTLELAKQIGE 706
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGR--DLLACAPTGSGKTLAFLIPILQKLGKPRKKkgLRALILAPTRELASQIYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 707 VVEKMGKFIdNLKIHYAIKGGNMAAMRGRKLTEQ--IVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMiYHQGFTDI 784
Cdd:cd17957 79 ELLKLSKGT-GLRIVLLSKSLEAKAKDGPKSITKydILVSTPLRLVFLLKQGP-IDLSSVEYLVLDEADKL-FEPGFREQ 155
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 17536103 785 STTIYNMVEdaSDSVQSMLFSATYDEPVINFATKIIKNAIVVM 827
Cdd:cd17957 156 TDEILAACT--NPNLQRSLFSATIPSEVEELARSVMKDPIRII 196
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
619-824 |
2.46e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 105.26 E-value: 2.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 619 SFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRI----------DVNLMC 688
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAG--RDLMACAQTGSGKTAAFLLPIISKLledgppsvgrGRRKAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 689 PQCICLAPTLELAKQIGEVVEkmgKFIDN--LK--IHYaikGGnmAAMRGRKLTEQ----IVIGTPGITRDYLQKYKcID 760
Cdd:cd17967 79 PSALILAPTRELAIQIYEEAR---KFSYRsgVRsvVVY---GG--ADVVHQQLQLLrgcdILVATPGRLVDFIERGR-IS 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536103 761 PSKIRCLVLDEADVMIyHQGF-TDISTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAI 824
Cdd:cd17967 150 LSSIKFLVLDEADRML-DMGFePQIRKIVEHPDMPPKGERQTLMFSATFPREIQRLAADFLKNYI 213
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
625-828 |
4.35e-25 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 104.20 E-value: 4.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 625 LKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRI------DVNLMCPQCICLAPTL 698
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEG--KDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 699 ELAKQIGEVVEKMGKFIDNLKIHYAIKGGNMAAMRGRKLTEQ--IVIGTPGITRDYLQKYKCIDPSKIRCLVLDEAD-VM 775
Cdd:cd17961 79 ELAQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKpdIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADlVL 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 17536103 776 IYhqGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVVML 828
Cdd:cd17961 159 SY--GYEE---DLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
620-812 |
4.56e-25 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 103.84 E-value: 4.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLE 699
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAG--RDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFIdNLKiHYAIKGGnMAAMRGRKLTEQ---IVIGTPGITRDYLQkykcIDP------SKIRCLVLD 770
Cdd:cd17955 79 LAYQIAEQFRALGAPL-GLR-CCVIVGG-MDMVKQALELSKrphIVVATPGRLADHLR----SSDdttkvlSRVKFLVLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 17536103 771 EADVMIyHQGFTDISTTIYNMVEdasDSVQSMLFSATYDEPV 812
Cdd:cd17955 152 EADRLL-TGSFEDDLATILSALP---PKRQTLLFSATLTDAL 189
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
879-976 |
1.84e-24 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 98.05 E-value: 1.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 879 WLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPIkytdegtpmvvdgft 958
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPW--------------- 66
|
90
....*....|....*...
gi 17536103 959 qpDCETYLHRIGRTGRFG 976
Cdd:smart00490 67 --SPASYIQRIGRAGRAG 82
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
618-826 |
6.66e-23 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 97.76 E-value: 6.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 618 SSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRidvnLMCPQCI----- 692
Cdd:cd17959 1 GGFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLIL--DGRDVVAMARTGSGKTAAFLIPMIEK----LKAHSPTvgara 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 693 -CLAPTLELAKQIGEVVEKMGKFIDnLKIhYAIKGGNmaamrgrKLTEQ---------IVIGTPGITRDYLQKYKcIDPS 762
Cdd:cd17959 75 lILSPTRELALQTLKVTKELGKFTD-LRT-ALLVGGD-------SLEEQfealasnpdIIIATPGRLLHLLVEMN-LKLS 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17536103 763 KIRCLVLDEADvMIYHQGFTDistTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17959 145 SVEYVVFDEAD-RLFEMGFAE---QLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
633-826 |
1.02e-22 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 96.85 E-value: 1.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 633 LDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQCICLAPTLELAKQIGEVVEKMG 712
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 713 KFIDNLKIHYAIKGGNMAAMRGR-KLTEQIVIGTPGITRDYLQKYkCIDPSKIRCLVLDEADVMIyHQGFTDistTIYNM 791
Cdd:cd17962 83 KGLPPMKTALLVGGLPLPPQLYRlQQGVKVIIATPGRLLDILKQS-SVELDNIKIVVVDEADTML-KMGFQQ---QVLDI 157
|
170 180 190
....*....|....*....|....*....|....*
gi 17536103 792 VEDASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17962 158 LENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
629-807 |
2.17e-22 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 96.92 E-value: 2.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEPpSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC---------PQCICLAPTLE 699
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDG-KDVIGAAETGSGKTLAFGIPILERLLSQKSSngvggkqkpLRALILTPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFIdNLKIhYAIKGGnMAAMRGRKLTEQ---IVIGTPG-----ITRD--YLQKYKcidpsKIRCLVL 769
Cdd:cd17946 80 LAVQVKDHLKAIAKYT-NIKI-ASIVGG-LAVQKQERLLKKrpeIVVATPGrlwelIQEGneHLANLK-----SLRFLVL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17536103 770 DEADVMI---YHQGFTDISTTIYNMVEDASDSVQSMLFSAT 807
Cdd:cd17946 152 DEADRMLekgHFAELEKILELLNKDRAGKKRKRQTFVFSAT 192
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
629-826 |
3.12e-22 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 96.24 E-value: 3.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMepPSNLIAQAQSGTGKTAAFVLTMLCRID-----VNLMC---PQCICLAPTLEL 700
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQ--NRDIIGIAETGSGKTAAFLIPLLVYISrlpplDEETKddgPYALILAPTREL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 701 AKQIGEVVEKMGKFIdNLKIhYAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIyH 778
Cdd:cd17945 79 AQQIEEETQKFAKPL-GIRV-VSIVGGHSIEEQAFSLRNgcEILIATPGRLLDCLER-RLLVLNQCTYVVLDEADRMI-D 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536103 779 QGFTDISTTIY------NMVEDASDSV-----------QSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17945 155 MGFEPQVTKILdampvsNKKPDTEEAEklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
629-773 |
3.39e-22 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 95.72 E-value: 3.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFV---LTMLCRIDVNLMCPQ--CICLAPTLELAKQ 703
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSN--KDVVVEAVTGSGKTLAFLipvLEILLKRKANLKKGQvgALIISPTRELATQ 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536103 704 IGEVVEKMGKFI-DNLKIHYAIkGGNMAAMRGRKLTE---QIVIGTPGITRDYLQ-KYKCIDPSKIRCLVLDEAD 773
Cdd:cd17960 79 IYEVLQSFLEHHlPKLKCQLLI-GGTNVEEDVKKFKRngpNILVGTPGRLEELLSrKADKVKVKSLEVLVLDEAD 152
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
630-826 |
2.56e-21 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 92.74 E-value: 2.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 630 LKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQ----CICLAPTLELAKQIG 705
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQG--RDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEdglgALIISPTRELAMQIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 706 EVVEKMGKFiDNLKIHYAIKGGNMAAMRGRKLTEQIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADvMIYHQGFtdiS 785
Cdd:cd17941 80 EVLRKVGKY-HSFSAGLIIGGKDVKEEKERINRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEAD-RILDMGF---K 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17536103 786 TTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17941 155 ETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
629-826 |
1.64e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 90.51 E-value: 1.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC-----PQCICLAPTLELAKQ 703
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMAL--SGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLergdgPIVLVLAPTRELAQQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 704 IGEVVEKMGKfIDNLKiHYAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIyHQGF 781
Cdd:cd17966 79 IQQEANKFGG-SSRLR-NTCVYGGAPKGPQIRDLRRgvEICIATPGRLIDFLDQ-GKTNLRRVTYLVLDEADRML-DMGF 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 17536103 782 tdiSTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17966 155 ---EPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
629-826 |
7.91e-20 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 88.63 E-value: 7.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLcridVNLM---------CPQCICLAPTLE 699
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVAL--SGRDMIGIAKTGSGKTAAFIWPML----VHIMdqrelekgeGPIAVIVAPTRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFIdNLKIHYAIKGGNMAAMRgRKLTE--QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMiY 777
Cdd:cd17952 75 LAQQIYLEAKKFGKAY-NLRVVAVYGGGSKWEQA-KALQEgaEIVVATPGRLIDMVKK-KATNLQRVTYLVLDEADRM-F 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 17536103 778 HQGFtdiSTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17952 151 DMGF---EYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
629-826 |
1.43e-19 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 87.90 E-value: 1.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC------PQCICLAPTLELAK 702
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQG--IDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPreqrngPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 703 QI-GEVVEKMGKFIDNLKIHyaikGGNMAAMRGRKLTE--QIVIGTPGITRDyLQKYKCIDPSKIRCLVLDEADVMIyHQ 779
Cdd:cd17958 79 QIeAECSKYSYKGLKSVCVY----GGGNRNEQIEDLSKgvDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRML-DM 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 17536103 780 GFtdiSTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17958 153 GF---EPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
630-807 |
4.01e-18 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 83.56 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 630 LKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCPQ----CICLAPTLELAKQIG 705
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEG--RDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRngtgVIIISPTRELALQIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 706 EVVEKMGKFidNLKIHYAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADvMIYHQGFTD 783
Cdd:cd17942 80 GVAKELLKY--HSQTFGIVIGGANRKAEAEKLGKgvNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEAD-RILEIGFEE 156
|
170 180
....*....|....*....|....
gi 17536103 784 ISTTIYNMVEDASdsvQSMLFSAT 807
Cdd:cd17942 157 EMRQIIKLLPKRR---QTMLFSAT 177
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
629-826 |
6.09e-18 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 83.54 E-value: 6.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTML--CrIDVNLMCPQC-------ICLAPTLE 699
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSG--RDMIGIAFTGSGKTLVFTLPLImfA-LEQEKKLPFIkgegpygLIVCPSRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 700 LAKQIGEVVEKMGKFID-----NLKIHYAIKGGNMA-AMRGRKLTEQIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEAD 773
Cdd:cd17951 78 LARQTHEVIEYYCKALQeggypQLRCLLCIGGMSVKeQLEVIRKGVHIVVATPGRLMDMLNK-KKINLDICRYLCLDEAD 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 17536103 774 VMIyHQGFTDISTTIYNMVEDASdsvQSMLFSATYDEPVINFATKIIKNAIVV 826
Cdd:cd17951 157 RMI-DMGFEEDIRTIFSYFKGQR---QTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
659-821 |
6.26e-18 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 83.36 E-value: 6.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 659 NLIAQAQSGTGKTAAFVLTMLCRIDVNLM------CPQCICLAPTLELAKQIGEVVEKMGKFIdNLKIHYAIK--GGNMA 730
Cdd:cd17944 29 DLIAQARTGTGKTFSFAIPLIEKLQEDQQprkrgrAPKVLVLAPTRELANQVTKDFKDITRKL-SVACFYGGTpyQQQIF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 731 AMRGrklTEQIVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMIyHQGFTDISTTIYNMV--EDASDSVQSMLFSATY 808
Cdd:cd17944 108 AIRN---GIDILVGTPGRIKDHLQNGR-LDLTKLKHVVLDEVDQML-DMGFAEQVEEILSVSykKDSEDNPQTLLFSATC 182
|
170
....*....|...
gi 17536103 809 DEPVINFATKIIK 821
Cdd:cd17944 183 PDWVYNVAKKYMK 195
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
617-822 |
1.23e-16 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 81.21 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 617 ISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC-----PQC 691
Cdd:cd18050 61 VFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLAL--SGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLergdgPIC 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 692 ICLAPTLELAKQIGEVVEKMGKfIDNLKiHYAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQKYKCidpSKIRC--L 767
Cdd:cd18050 139 LVLAPTRELAQQVQQVADDYGK-SSRLK-STCIYGGAPKGPQIRDLERgvEICIATPGRLIDFLEAGKT---NLRRCtyL 213
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 17536103 768 VLDEADVMIyHQGFtdiSTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKN 822
Cdd:cd18050 214 VLDEADRML-DMGF---EPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRD 264
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
617-824 |
2.59e-16 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 78.96 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 617 ISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC-----PQC 691
Cdd:cd17953 11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIM--SGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVkpgegPIG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 692 ICLAPTLELAKQIGEVVEKMGKFIdNLKIHYAIKGGNMAAMRGR-KLTEQIVIGTPGITRDYLqkykCIDPSKI----RC 766
Cdd:cd17953 89 LIMAPTRELALQIYVECKKFSKAL-GLRVVCVYGGSGISEQIAElKRGAEIVVCTPGRMIDIL----TANNGRVtnlrRV 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 767 --LVLDEADVMiYHQGFTDISTTIYNMVEDASdsvQSMLFSATYDEPVINFATKIIKNAI 824
Cdd:cd17953 164 tyVVLDEADRM-FDMGFEPQIMKIVNNIRPDR---QTVLFSATFPRKVEALARKVLHKPI 219
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
617-824 |
3.20e-16 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 79.28 E-value: 3.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 617 ISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLmePPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMC-----PQC 691
Cdd:cd18049 23 VLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVAL--SGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLergdgPIC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 692 ICLAPTLELAKQIGEVVEKMGKfIDNLKiHYAIKGGNMAAMRGRKLTE--QIVIGTPGITRDYLQkykCIDPSKIRC--L 767
Cdd:cd18049 101 LVLAPTRELAQQVQQVAAEYGR-ACRLK-STCIYGGAPKGPQIRDLERgvEICIATPGRLIDFLE---AGKTNLRRCtyL 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 17536103 768 VLDEADVMIyHQGFtdiSTTIYNMVEDASDSVQSMLFSATYDEPVINFATKIIKNAI 824
Cdd:cd18049 176 VLDEADRML-DMGF---EPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYI 228
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
599-808 |
5.07e-16 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 78.93 E-value: 5.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 599 KDVVVDVQRQDPKSPlysISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTM 678
Cdd:cd18051 5 EDIPVEATGENCPPH---IETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSK--RDLMACAQTGSGKTAAFLLPI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 679 LCRI-----DVNLMC-----------PQCICLAPTLELAKQIgevVEKMGKFIDNLKIHYA-IKGGN--MAAMRGRKLTE 739
Cdd:cd18051 80 LSQIyeqgpGESLPSesgyygrrkqyPLALVLAPTRELASQI---YDEARKFAYRSRVRPCvVYGGAdiGQQMRDLERGC 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17536103 740 QIVIGTPGITRDYLQKYKcIDPSKIRCLVLDEADVMIyHQGFtdiSTTIYNMVED----ASDSVQSMLFSATY 808
Cdd:cd18051 157 HLLVATPGRLVDMLERGK-IGLDYCKYLVLDEADRML-DMGF---EPQIRRIVEQdtmpPTGERQTLMFSATF 224
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
629-783 |
5.46e-13 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 69.70 E-value: 5.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQFPTRIQETALPLLLMEppSNLIAQAQSGTGKTAAFVLTMLCRI-------DVNLMCPQCICLAPTLELA 701
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRG--RNTLCAAETGSGKTLTYLLPIIQRLlrykllaEGPFNAPRGLVITPSRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 702 KQIGEVVEKMGKFIdNLKIHyAIKGGN-MAAMRGRKLTE-QIVIGTPGITRDYLQKyKCIDPSKIRCLVLDEADVMIyHQ 779
Cdd:cd17948 79 EQIGSVAQSLTEGL-GLKVK-VITGGRtKRQIRNPHFEEvDILVATPGALSKLLTS-RIYSLEQLRHLVLDEADTLL-DD 154
|
....
gi 17536103 780 GFTD 783
Cdd:cd17948 155 SFNE 158
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
629-807 |
5.93e-13 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 69.58 E-value: 5.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 629 VLKALDTMNFQ--FPtrIQETALPLLLME-------PPSNLIAQAQSGTGKTAAFVLTML--------CRIdvnlmcpQC 691
Cdd:cd17956 1 LLKNLQNNGITsaFP--VQAAVIPWLLPSskstppyRPGDLCVSAPTGSGKTLAYVLPIVqalskrvvPRL-------RA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 692 ICLAPTLELAKQIGEVVEKmgkFIDNLKIHYAIKGGNMA---AMRGRKLTE--------QIVIGTPGITRDYLQKYKCID 760
Cdd:cd17956 72 LIVVPTKELVQQVYKVFES---LCKGTGLKVVSLSGQKSfkkEQKLLLVDTsgrylsrvDILVATPGRLVDHLNSTPGFT 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17536103 761 PSKIRCLVLDEADVMI--YHQGFTDI--------------STTIYNMVEDASDSVQSMLFSAT 807
Cdd:cd17956 149 LKHLRFLVIDEADRLLnqSFQDWLETvmkalgrptapdlgSFGDANLLERSVRPLQKLLFSAT 211
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
667-937 |
3.33e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 63.89 E-value: 3.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 667 GTGKT--AAFVLTMLCRIDVnlmcpqCICLAPTLELAKQIgevVEKMGKFIDNlkihyAIKGGNMaamrgRKLTEQIVIG 744
Cdd:COG1061 110 GTGKTvlALALAAELLRGKR------VLVLVPRRELLEQW---AEELRRFLGD-----PLAGGGK-----KDSDAPITVA 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 745 TPG--ITRDYLQKYkcidPSKIRCLVLDEAdvmiyHQgftdISTTIYNMVEDASDSVQSMLFSATY------DEPVINFA 816
Cdd:COG1061 171 TYQslARRAHLDEL----GDRFGLVIIDEA-----HH----AGAPSYRRILEAFPAAYRLGLTATPfrsdgrEILLFLFD 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 817 TKIIKNAIVVMLKREEQALPNIKQFYVQCACRDSKYAAIVNLYSGLAVASS--------------------VIFCHTKAS 876
Cdd:COG1061 238 GIVYEYSLKEAIEDGYLAPPEYYGIRVDLTDERAEYDALSERLREALAADAerkdkilrellrehpddrktLVFCSSVDH 317
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17536103 877 VMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVI 937
Cdd:COG1061 318 AEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
620-807 |
1.81e-09 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 59.70 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 620 FRELRLKPEVLKAL---------DTMNFQFPTRIQETALPLLLMEPPSN---------------LIAqAQSGTGKTAAFV 675
Cdd:cd17965 1 FDQLKLLPSVREAIikeilkgsnKTDEEIKPSPIQTLAIKKLLKTLMRKvtkqtsneepklevfLLA-AETGSGKTLAYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 676 LTMLCRID-----------------VNLMCPQCICLAPTLELAKQIGEVVEKMGKFIdNLKIHyAIKgGNMAAMRGRKLT 738
Cdd:cd17965 80 APLLDYLKrqeqepfeeaeeeyesaKDTGRPRSVILVPTHELVEQVYSVLKKLSHTV-KLGIK-TFS-SGFGPSYQRLQL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17536103 739 E-----QIVIGTPGItrdyLQKYKCIDP---SKIRCLVLDEADVMiYHQGFTDISTTIynmVEDASDSVQSMLFSAT 807
Cdd:cd17965 157 AfkgriDILVTTPGK----LASLAKSRPkilSRVTHLVVDEADTL-FDRSFLQDTTSI---IKRAPKLKHLILCSAT 225
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
836-989 |
7.20e-09 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 59.38 E-value: 7.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 836 PNIkQFYVQCACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDF 915
Cdd:COG0514 203 PNL-RLEVVPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEV 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17536103 916 KVLITTNVFARGIDVAQVSVVINYDLPikytdeGTPmvvdgftqpdcETYLHRIGRTGRFGKTGIAINLIDSED 989
Cdd:COG0514 282 DVIVATIAFGMGIDKPDVRFVIHYDLP------KSI-----------EAYYQEIGRAGRDGLPAEALLLYGPED 338
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
866-982 |
1.38e-08 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 54.14 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 866 SSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPiky 945
Cdd:cd18794 32 SGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLP--- 108
|
90 100 110
....*....|....*....|....*....|....*..
gi 17536103 946 tdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAI 982
Cdd:cd18794 109 --------------KSMESYYQESGRAGRDGLPSECI 131
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
867-942 |
5.48e-08 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 52.48 E-value: 5.48e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17536103 867 SVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKR--GDFKVLITTNVFARGIDVAQVSVVINYDLP 942
Cdd:cd18793 30 VLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLSTKAGGVGLNLTAANRVILYDPW 107
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
898-994 |
6.84e-08 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 56.66 E-value: 6.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 898 MTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDL---PIKytdegtpmvvdgftqpdcetYLHRIGRTGR 974
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPvpsEIR--------------------SIQRKGRTGR 454
|
90 100
....*....|....*....|
gi 17536103 975 FGKtGIAINLIdSEDSMNMI 994
Cdd:COG1111 455 KRE-GRVVVLI-AKGTRDEA 472
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
658-807 |
1.29e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 52.02 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 658 SNLIAQAQSGTGKTAAFVLTMLCRIDVNLmcPQCICLAPTLELAKQIGEVVekMGKFIDNLKIHYAIKGGNMAAMRGRKL 737
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTKALALQTAERL--RELFGPGIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17536103 738 -TEQIVIGTPGITRDYLQKYKCIDPSKIRCLVLDEADVM-IYHQGFTDISTTIYNMvedASDSVQSMLFSAT 807
Cdd:cd00046 78 gDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALlIDSRGALILDLAVRKA---GLKNAQVILLSAT 146
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
866-989 |
1.45e-06 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 52.02 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 866 SSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPiky 945
Cdd:PRK11057 238 SGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIP--- 314
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 17536103 946 tdegtpmvvdgftqPDCETYLHRIGRTGRFGKTGIAINLIDSED 989
Cdd:PRK11057 315 --------------RNIESYYQETGRAGRDGLPAEAMLFYDPAD 344
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
868-942 |
4.05e-06 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 47.59 E-value: 4.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 868 VIFCHTKASVMWLYE----------NMRA-----RGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQ 932
Cdd:cd18802 29 IIFVERRATAVVLSRllkehpstlaFIRCgfligRGNSSQRKRSLMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPA 108
|
90
....*....|
gi 17536103 933 VSVVINYDLP 942
Cdd:cd18802 109 CNLVIRFDLP 118
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
658-772 |
1.60e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 46.88 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 658 SNLIAQAQSGTGKT--AAFVLTMLCRIDVNLMCPQCIC--LAPTLELAKQIGEVVEKmgkFIDNLKIHYAIKGGNMAAMR 733
Cdd:cd18034 17 RNTIVVLPTGSGKTliAVMLIKEMGELNRKEKNPKKRAvfLVPTVPLVAQQAEAIRS---HTDLKVGEYSGEMGVDKWTK 93
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 17536103 734 GRKLTE----QIVIGTPGITRDYLQKYKcIDPSKIRCLVLDEA 772
Cdd:cd18034 94 ERWKEElekyDVLVMTAQILLDALRHGF-LSLSDINLLIFDEC 135
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
868-976 |
1.62e-05 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 49.07 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 868 VIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRG-DFKV-LITTNVFARGIDVAQVSVVINYDLPIky 945
Cdd:COG0553 553 LVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGpEAPVfLISLKAGGEGLNLTAADHVIHYDLWW-- 630
|
90 100 110
....*....|....*....|....*....|.
gi 17536103 946 tdegTPMVVDgftQpdcetylhRIGRTGRFG 976
Cdd:COG0553 631 ----NPAVEE---Q--------AIDRAHRIG 646
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
858-974 |
1.62e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 45.72 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 858 LYSGLAVASSVIFCHTKASVMWLYENMRAR------GHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVA 931
Cdd:cd18796 32 IFLLERHKSTLVFTNTRSQAERLAQRLRELcpdrvpPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIG 111
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 17536103 932 QVSVVINYdlpikytdeGTPMVVDGFTQpdcetylhRIGRTGR 974
Cdd:cd18796 112 DVDLVIQI---------GSPKSVARLLQ--------RLGRSGH 137
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
898-974 |
1.04e-04 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 43.50 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 898 MTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDL---PIKytdegtpmvvdgftqpdcetYLHRIGRTGR 974
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDAspsPIR--------------------MIQRMGRTGR 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
915-979 |
1.32e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.15 E-value: 1.32e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536103 915 FKVLITTNVFARGIDVAQVSVVINYDLPIKYTDegtpmvvdgftqpdcetYLHRIGRTGRFGKTG 979
Cdd:cd18785 23 LEILVATNVLGEGIDVPSLDTVIFFDPPSSAAS-----------------YIQRVGRAGRGGKDE 70
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
898-985 |
3.80e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 44.48 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 898 MTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINYDlPIkytdegtpmvvdgftqPDCETYLHRIGRTGRfGK 977
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYE-PV----------------PSEIRSIQRKGRTGR-QE 468
|
....*...
gi 17536103 978 TGIAINLI 985
Cdd:PRK13766 469 EGRVVVLI 476
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
901-991 |
2.42e-03 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 41.74 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 901 VERAdtiihFKRGDFKVLITTNVFARGIDVAQVSVVINYDLPikytdeGTPMvvdGFTQpdcetylhRIGRTGRFGKTGI 980
Cdd:COG1205 336 IERG-----LRSGELLGVVSTNALELGIDIGGLDAVVLAGYP------GTRA---SFWQ--------QAGRAGRRGQDSL 393
|
90
....*....|.
gi 17536103 981 AInLIDSEDSM 991
Cdd:COG1205 394 VV-LVAGDDPL 403
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
766-977 |
3.82e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 40.88 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 766 CLVLDEADVMI-YHQGFtdisttIYNMVEDASD-SVQSMLFSATYDEPVINFATKIiknAIVVMLKREEQAlPNIKQFYV 843
Cdd:cd09639 126 LLIFDEVHFYDeYTLAL------ILAVLEVLKDnDVPILLMSATLPKFLKEYAEKI---GYVEENEPLDLK-PNERAPFI 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 844 QCACRDSKYAAIVN--LYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDV--LHGDMTVVERADT----IIHFKRGDF 915
Cdd:cd09639 196 KIESDKVGEISSLErlLEFIKKGGSVAIIVNTVDRAQEFYQQLKEKGPEEEImlIHSRFTEKDRAKKeaelLLEFKKSEK 275
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17536103 916 KVLITTNvfargidVAQVSVVINYDLPIkyTDEGTPmvvDGFTQpdcetylhRIGRTGRFGK 977
Cdd:cd09639 276 FVIVATQ-------VIEASLDISVDVMI--TELAPI---DSLIQ--------RLGRLHRYGE 317
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
659-807 |
7.12e-03 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 38.95 E-value: 7.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 659 NLIAQAQSGTGKTAAFVLTMLCRI--------DVNLMCPQCICLAPTLELAkqiGEVVEKMGKFIDNLKIHYAIKGGNMA 730
Cdd:cd18020 19 NMLICAPTGAGKTNIAMLTILHEIrqhvnqggVIKKDDFKIVYIAPMKALA---AEMVEKFSKRLAPLGIKVKELTGDMQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536103 731 AMRGRKLTEQIVIGTPG----ITRDYLQKYKCIdpSKIRCLVLDEadVMIYHQGFTDISTTIYNMVEDASDSVQSML--- 803
Cdd:cd18020 96 LTKKEIAETQIIVTTPEkwdvVTRKSSGDVALS--QLVRLLIIDE--VHLLHDDRGPVIESLVARTLRQVESTQSMIriv 171
|
....*
gi 17536103 804 -FSAT 807
Cdd:cd18020 172 gLSAT 176
|
|
| |
