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    ift-139 Tetratricopeptide repeat protein 21 homolog [ Caenorhabditis elegans ]

    Gene ID: 175855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ift-139
    Official Full Name
    Tetratricopeptide repeat protein 21 homolog
    Primary source
    WormBase:WBGene00022696
    Locus tag
    CELE_ZK328.7
    See related
    AllianceGenome:WB:WBGene00022696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in intraciliary retrograde transport and protein localization to cilium. Predicted to be located in several cellular components, including cilium; cytoskeleton; and dendrite. Predicted to be part of intraciliary transport particle A. Is expressed in neurons. Used to study nephronophthisis. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 4; nephronophthisis 12; and spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A) and TTC21B (tetratricopeptide repeat domain 21B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ift-139 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (6032563..6039470, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative F-box protein ZK328.6 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Putative T-box protein 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans. Niwa S. Sci Rep, 2016 Aug 12. PMID 27515926, Free PMC Article
    2. Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans. Higashida M, et al. Genes Cells, 2023 Feb. PMID 36461782
    3. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320
    4. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950
    5. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that ift-139 is evolutionarily conserved and fundamental to the formation of cilia.
      Title: The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tetratricopeptide repeat protein 21 homolog
    NP_001022993.2
    • Confirmed by transcript evidence
    NP_001022994.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6032563..6039470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027822.5 → NP_001022993.2  Tetratricopeptide repeat protein 21 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022993.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20255, Q23468, Q7Z146
      Conserved Domains (2) summary
      sd00006
      Location:1206 → 1233
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:740 → 802
      TPR_11; TPR repeat

    2. NM_001027823.4 → NP_001022994.1  Tetratricopeptide repeat protein 21 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20255
      Conserved Domains (3) summary
      COG0457
      Location:618 → 784
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:707 → 732
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:740 → 802
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20255.3

    Gene LinkOut

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