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    Fbxw7 F-box and WD-40 domain protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 50754, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fbxw7provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 7provided by MGI
    Primary source
    MGI:MGI:1354695
    See related
    Ensembl:ENSMUSG00000028086 AllianceGenome:MGI:1354695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxw6; Fbxo30; SEL-10; 1110001A17Rik
    Summary
    Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in protein catabolic process. Acts upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in central nervous system; early conceptus; genitourinary system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in cortex adult (RPKM 16.6), frontal lobe adult (RPKM 13.5) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbxw7 in Genome Data Viewer
    Location:
    3 F1; 3 37.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84721901..84886505)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84814990..84979198)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40079 Neighboring gene STARR-positive B cell enhancer ABC_E2072 Neighboring gene STARR-seq mESC enhancer starr_08092 Neighboring gene STARR-positive B cell enhancer ABC_E11196 Neighboring gene predicted gene, 35486 Neighboring gene predicted gene, 40080 Neighboring gene predicted gene, 46808 Neighboring gene STARR-seq mESC enhancer starr_08095 Neighboring gene STARR-seq mESC enhancer starr_08096 Neighboring gene STARR-seq mESC enhancer starr_08097 Neighboring gene STARR-seq mESC enhancer starr_08098 Neighboring gene STARR-seq mESC enhancer starr_08099 Neighboring gene predicted gene, 30944 Neighboring gene predicted gene, 30991

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding  
    enables cyclin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables phosphothreonine residue binding  
    enables phosphothreonine residue binding  
    enables protein binding PubMed 
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables ubiquitin binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-like ligase-substrate adaptor activity  
    enables ubiquitin-like ligase-substrate adaptor activity  
    enables ubiquitin-protein transferase activator activity  
    enables ubiquitin-protein transferase activator activity  
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA repair  
    acts_upstream_of_or_within Notch signaling pathway PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    involved_in cellular response to UV  
    involved_in cellular response to UV  
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of osteoclast development PubMed 
    involved_in negative regulation of osteoclast development  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of epidermal growth factor-activated receptor activity  
    involved_in positive regulation of epidermal growth factor-activated receptor activity  
    involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway PubMed 
    involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in positive regulation of proteasomal protein catabolic process PubMed 
    involved_in positive regulation of proteasomal protein catabolic process  
    involved_in positive regulation of protein targeting to mitochondrion  
    involved_in positive regulation of protein targeting to mitochondrion  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of ubiquitin-protein transferase activity  
    involved_in positive regulation of ubiquitin-protein transferase activity  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein K63-linked ubiquitination  
    acts_upstream_of_or_within protein destabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    acts_upstream_of_or_within protein ubiquitination PubMed 
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in regulation of cell migration involved in sprouting angiogenesis PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of mitophagy  
    involved_in regulation of mitophagy  
    involved_in rhythmic process  
    involved_in sister chromatid cohesion  
    involved_in sister chromatid cohesion  
    involved_in ubiquitin recycling  
    acts_upstream_of_or_within vasculogenesis PubMed 
    Items 1 - 25 of 51
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex  
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex  
    located_in chromosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in membrane PubMed 
    located_in mitochondrion PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    NOT located_in nucleus PubMed 
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    part_of protein-containing complex  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 7
    Names
    F-box and WD-40 domain protein 7, archipelago homolog
    F-box and WD-40 domain-containing protein 7
    F-box-WD40 repeat protein 6
    f-box only protein 30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177773.2NP_001171244.1  F-box/WD repeat-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001171244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AC124496, AC158583
      Consensus CDS
      CCDS50940.1
      UniProtKB/Swiss-Prot
      A2RRI5, D3YUA5, Q8CCS5, Q8VBV4, Q8VHP4
      Related
      ENSMUSP00000103306.2, ENSMUST00000107679.8
      Conserved Domains (3) summary
      cd00200
      Location:377653
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:387422
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:284328
      F-box-like
    2. NM_001177774.2NP_001171245.1  F-box/WD repeat-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001171245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
      Source sequence(s)
      AC124496, AC158583
      Consensus CDS
      CCDS50940.1
      UniProtKB/Swiss-Prot
      A2RRI5, D3YUA5, Q8CCS5, Q8VBV4, Q8VHP4
      Related
      ENSMUSP00000103305.2, ENSMUST00000107678.8
      Conserved Domains (3) summary
      cd00200
      Location:377653
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:387422
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:284328
      F-box-like
    3. NM_001428748.1NP_001415677.1  F-box/WD repeat-containing protein 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks four 5' exons, but has an alternate 5' exon including coding region, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC124496, AC158583
      UniProtKB/TrEMBL
      D3YUA8
    4. NM_080428.4NP_536353.2  F-box/WD repeat-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_536353.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks four 5' exons, but has an alternate 5' exon including coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC124496, AC158583
      Consensus CDS
      CCDS17440.1
      UniProtKB/Swiss-Prot
      Q8VBV4
      Related
      ENSMUSP00000029727.8, ENSMUST00000029727.8
      Conserved Domains (3) summary
      cd00200
      Location:296572
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:306341
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:203247
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      84721901..84886505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501657.5XP_006501720.1  F-box/WD repeat-containing protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006501720.1

      UniProtKB/Swiss-Prot
      A2RRI5, D3YUA5, Q8CCS5, Q8VBV4, Q8VHP4
      Conserved Domains (3) summary
      cd00200
      Location:377653
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:387422
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:284328
      F-box-like
    2. XM_006501656.4XP_006501719.1  F-box/WD repeat-containing protein 7 isoform X1

      Conserved Domains (3) summary
      cd00200
      Location:377653
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:387422
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:284328
      F-box-like
    3. XM_006501658.4XP_006501721.1  F-box/WD repeat-containing protein 7 isoform X2

      Related
      ENSMUSP00000103302.2, ENSMUST00000107675.8
      Conserved Domains (3) summary
      cd00200
      Location:256532
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:266301
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:163207
      F-box-like
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