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Kras Kirsten rat sarcoma viral oncogene homolog [ Mus musculus (house mouse) ]

Gene ID: 16653, updated on 27-Nov-2024

Summary

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Official Symbol
Krasprovided by MGI
Official Full Name
Kirsten rat sarcoma viral oncogene homologprovided by MGI
Primary source
MGI:MGI:96680
See related
Ensembl:ENSMUSG00000030265 AllianceGenome:MGI:96680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
Summary
Enables GTPase activity and protein-membrane adaptor activity. Acts upstream of or within several processes, including Ras protein signal transduction; forebrain astrocyte development; and modulation of chemical synaptic transmission. Located in membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Kras in Genome Data Viewer
Location:
6 G3; 6 77.37 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145162425..145197631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145216699..145250420, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_17782 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:145252111-145252451 Neighboring gene lactate dehydrogenase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. Huang BJ, et al. PLoS Genet, 2019 Jun. PMID 31199785, Free PMC Article
  2. Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability. Luo F, et al. J Pathol, 2011 Feb. PMID 21171084
  3. Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. Shankar S, et al. PLoS One, 2011 Jan 31. PMID 21304978, Free PMC Article
  4. Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Sunaga N, et al. Mol Cancer Ther, 2011 Feb. PMID 21306997, Free PMC Article
  5. Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice. Bai H, et al. Carcinogenesis, 2011 Nov. PMID 21859833, Free PMC Article

See all (1000) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.
    Title: Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.
  2. Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth in preclinical models of lung cancer.
    Title: Inhibition of ULK1/2 and KRAS(G12C) controls tumor growth in preclinical models of lung cancer.
  3. The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.
    Title: The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.
  4. Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer.
    Title: Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer.
  5. Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
    Title: Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
  6. Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer.
    Title: Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer.
  7. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.
    Title: Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.
  8. CDKN2A-p16 Deletion and Activated KRAS[G12D] Drive Barrett's-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions.
    Title: CDKN2A-p16 Deletion and Activated KRAS(G12D) Drive Barrett's-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions.
  9. Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
    Title: Oncogenic K-Ras(G12V) cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
  10. Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Submit: New GeneRIF Correction See all GeneRIFs (471)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GMP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-membrane adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within forebrain astrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of type I pneumocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
GTPase KRas
Names
Kirsten rat sarcoma oncogene 2, expressed
p21 protein
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NP_001390169.1
NP_001390170.1
NP_001390171.1
NP_001390172.1
NP_001390173.1
NP_001390174.1
NP_001390175.1
NP_067259.4
XP_006506982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403240.1 → NP_001390169.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1

  2. NM_001403241.1 → NP_001390170.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1

  3. NM_001403242.1 → NP_001390171.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1

  4. NM_001403243.1 → NP_001390172.1  GTPase KRas isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/Swiss-Prot
    P04200, P08643, P32883
    UniProtKB/TrEMBL
    Q0VDV7
    Related
    ENSMUSP00000107339.2, ENSMUST00000111710.8

  5. NM_001403244.1 → NP_001390173.1  GTPase KRas isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157091

  6. NM_001403245.1 → NP_001390174.1  GTPase KRas isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157091

  7. NM_001403246.1 → NP_001390175.1  GTPase KRas isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    A0A0N4SVY1
    Related
    ENSMUSP00000145294.2, ENSMUST00000203147.3

  8. NM_021284.7 → NP_067259.4  GTPase KRas isoform 1

    See identical proteins and their annotated locations for NP_067259.4

    Status: VALIDATED

    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS20693.1
    UniProtKB/TrEMBL
    Q3U2W7, Q5J7N1
    Related
    ENSMUSP00000032399.6, ENSMUST00000032399.12
    Conserved Domains (2) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:16 → 166
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

RNA

  1. NR_175367.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157091

  2. NR_175368.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157091

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145162425..145197631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506919.5 → XP_006506982.1  GTPase KRas isoform X2

    See identical proteins and their annotated locations for XP_006506982.1

    UniProtKB/TrEMBL
    Q3U2W7
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32883.1 GenPept UniProtKB/Swiss-Prot:P32883

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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