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    ZNF107 zinc finger protein 107 [ Homo sapiens (human) ]

    Gene ID: 51427, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF107provided by HGNC
    Official Full Name
    zinc finger protein 107provided by HGNC
    Primary source
    HGNC:HGNC:12887
    See related
    Ensembl:ENSG00000196247 MIM:603989; AllianceGenome:HGNC:12887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Y8; ZFD25; ZNF588; smap-7
    Summary
    This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in lymph node (RPKM 5.5), appendix (RPKM 3.8) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF107 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64666133..64711577)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (65866222..65919062)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64126511..64171955)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128885 Neighboring gene BNIP3 pseudogene 44 Neighboring gene uncharacterized LOC124901656 Neighboring gene uncharacterized LOC105375326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26062 Neighboring gene BCL2 interacting protein 3 pseudogene 11 Neighboring gene microRNA 6839 Neighboring gene myelin protein zero like 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26063 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64254846-64255406 Neighboring gene zinc finger protein 138 Neighboring gene CRISPRi-validated cis-regulatory element chr7.2319 Neighboring gene selenophosphate synthetase 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 fingers. Li XA, et al. Biochim Biophys Acta, 1999 Dec 23. PMID 10673043
    2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
    3. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    4. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 107
    Names
    C2H2 type zinc-finger protein
    zinc finger protein (ZFD25)
    zinc finger protein 588

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013746.3 → NP_001013768.1  zinc finger protein 107 isoform a

      See identical proteins and their annotated locations for NP_001013768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC091799, BC047243, DA723595
      Consensus CDS
      CCDS5527.1
      UniProtKB/Swiss-Prot
      Q9UII5
      Related
      ENSP00000343443.3, ENST00000344930.7
      Conserved Domains (3) summary
      COG5048
      Location:186 → 655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001282359.2 → NP_001269288.1  zinc finger protein 107 isoform b

      See identical proteins and their annotated locations for NP_001269288.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a.
      Source sequence(s)
      AC091799, DA723595
      Consensus CDS
      CCDS75605.1
      UniProtKB/TrEMBL
      A0A0B4J2G0
      Related
      ENSP00000483720.1, ENST00000620827.6
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:255 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:483 → 503
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:523 → 548
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001282360.2 → NP_001269289.1  zinc finger protein 107 isoform c

      See identical proteins and their annotated locations for NP_001269289.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks four alternate exons and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (c) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC016769, AC091799
      Consensus CDS
      CCDS75606.1
      UniProtKB/TrEMBL
      A0A087WYK5
      Related
      ENSP00000481898.1, ENST00000613690.5
      Conserved Domains (5) summary
      smart00349
      Location:4 → 43
      KRAB; krueppel associated box
      COG5048
      Location:223 → 692
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:451 → 471
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:491 → 516
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001388025.1 → NP_001374954.1  zinc finger protein 107 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC016769, AC091799
      Conserved Domains (3) summary
      smart00349
      Location:48 → 108
      KRAB; krueppel associated box
      COG5048
      Location:551 → 863
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527 → 547
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001388026.1 → NP_001374955.1  zinc finger protein 107 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC016769, AC091799
      Conserved Domains (3) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      COG5048
      Location:512 → 824
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_016220.5 → NP_057304.1  zinc finger protein 107 isoform a

      See identical proteins and their annotated locations for NP_057304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC091799, BC017809, BC047243
      Consensus CDS
      CCDS5527.1
      UniProtKB/Swiss-Prot
      Q9UII5
      Related
      ENSP00000400037.1, ENST00000423627.6
      Conserved Domains (3) summary
      COG5048
      Location:186 → 655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_104148.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple 3' exons and contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC016769

    2. NR_104149.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks multiple exons and contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC016769

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      64666133..64711577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420452.1 → XP_047276408.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    2. XM_017012286.2 → XP_016867775.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5
      Conserved Domains (3) summary
      COG5048
      Location:186 → 655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047420451.1 → XP_047276407.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      65866222..65919062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358348.1 → XP_054214323.1  zinc finger protein 107 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J2G0

    2. XM_054358350.1 → XP_054214325.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    3. XM_054358349.1 → XP_054214324.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    4. XM_054358351.1 → XP_054214326.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    5. XM_054358354.1 → XP_054214329.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    6. XM_054358353.1 → XP_054214328.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5

    7. XM_054358352.1 → XP_054214327.1  zinc finger protein 107 isoform X1

      UniProtKB/Swiss-Prot
      Q9UII5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UII5.1 GenPept UniProtKB/Swiss-Prot:Q9UII5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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