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    Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) [ Mus musculus (house mouse) ]

    Gene ID: 108155, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ogtprovided by MGI
    Official Full Name
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)provided by MGI
    Primary source
    MGI:MGI:1339639
    See related
    Ensembl:ENSMUSG00000034160 AllianceGenome:MGI:1339639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ogtl; 1110038P24Rik; 4831420N21Rik
    Summary
    Enables chromatin DNA binding activity and protein O-acetylglucosaminyltransferase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and regulation of primary metabolic process. Acts upstream of or within protein O-linked glycosylation. Is active in glutamatergic synapse and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study congenital disorder of glycosylation. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 101.0), CNS E18 (RPKM 90.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Ogt in Genome Data Viewer
    Location:
    X D; X 44.45 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100683617..100727957)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101640011..101684351)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2537 Neighboring gene ring finger protein 26 pseudogene Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_47657 Neighboring gene STARR-seq mESC enhancer starr_47659 Neighboring gene RNA binding protein pseudogene Neighboring gene predicted gene, 52429

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity PubMed 
    enables RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity  
    enables RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity  
    enables catalytic activity PubMed 
    enables chromatin DNA binding PubMed 
    enables identical protein binding  
    enables peptide binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables protein O-acetylglucosaminyltransferase activity  
    enables protein O-acetylglucosaminyltransferase activity PubMed 
    enables protein O-acetylglucosaminyltransferase activity PubMed 
    enables protein O-acetylglucosaminyltransferase activity  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein-containing complex binding  
    Items 1 - 25 of 66
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to lipopolysaccharide  
    involved_in chromatin organization  
    involved_in circadian regulation of gene expression PubMed 
    involved_in glucosamine metabolic process  
    involved_in hemopoiesis PubMed 
    involved_in intracellular distribution of mitochondria  
    involved_in mitophagy PubMed 
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of cellular response to hypoxia  
    involved_in negative regulation of non-canonical inflammasome complex assembly  
    involved_in negative regulation of peptidyl-serine phosphorylation  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of protein targeting to membrane  
    involved_in negative regulation of protein ubiquitination PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of stem cell population maintenance PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of cell size  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of lipid biosynthetic process PubMed 
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of proteolysis  
    involved_in positive regulation of proteolysis  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of stem cell population maintenance PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose PubMed 
    involved_in positive regulation of translation  
    involved_in positive regulation of translation  
    involved_in protein O-linked glycosylation  
    acts_upstream_of_or_within protein O-linked glycosylation PubMed 
    involved_in protein O-linked glycosylation  
    acts_upstream_of_or_within protein O-linked glycosylation PubMed 
    involved_in protein O-linked glycosylation  
    acts_upstream_of_or_within protein O-linked glycosylation PubMed 
    involved_in protein processing  
    involved_in protein processing  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of Rac protein signal transduction  
    involved_in regulation of gluconeogenesis PubMed 
    involved_in regulation of glycolytic process  
    involved_in regulation of glycolytic process  
    involved_in regulation of insulin receptor signaling pathway  
    involved_in regulation of insulin receptor signaling pathway  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of synapse assembly PubMed 
    involved_in regulation of synapse assembly PubMed 
    involved_in regulation of synapse assembly PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to insulin  
    involved_in response to insulin  
    Items 1 - 25 of 66
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    part_of NSL complex  
    part_of Sin3-type complex PubMed 
    located_in cell projection  
    is_active_in cerebellar granule cell to Purkinje cell synapse  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in euchromatin  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    part_of histone acetyltransferase complex  
    part_of histone acetyltransferase complex  
    located_in intracellular anatomical structure PubMed 
    located_in mitochondrial membrane  
    located_in neuronal cell body  
    located_in nucleoplasm  
    is_active_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic cytosol  
    is_active_in presynaptic cytosol  
    part_of protein N-acetylglucosaminyltransferase complex  
    part_of protein N-acetylglucosaminyltransferase complex  
    part_of protein-containing complex  
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 
    located_in zymogen granule  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Names
    O-GlcNAc transferase subunit p110
    O-linked N-acetylglucosamine transferase 110 kDa subunit
    NP_001277464.1
    NP_631883.2
    XP_006527799.1
    XP_011245805.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290535.1NP_001277464.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

      See identical proteins and their annotated locations for NP_001277464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK045910, BC057319, CB520299, CD544482
      Consensus CDS
      CCDS72415.1
      UniProtKB/Swiss-Prot
      Q8CGY8
      Conserved Domains (3) summary
      TIGR02917
      Location:23455
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:317345
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:5461014
      Glyco_transf_41; Glycosyl transferase family 41
    2. NM_139144.4NP_631883.2  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

      See identical proteins and their annotated locations for NP_631883.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK045910, BC057319, BY196484, CF166269
      Consensus CDS
      CCDS30318.1
      UniProtKB/Swiss-Prot
      A2ALY1, Q6PG10, Q8BXH6, Q8CGY8, Q91Y38
      Related
      ENSMUSP00000045409.5, ENSMUST00000044475.5
      Conserved Domains (3) summary
      TIGR02917
      Location:22465
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:327355
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:5561024
      Glyco_transf_41; Glycosyl transferase family 41

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      100683617..100727957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527736.4XP_006527799.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

      See identical proteins and their annotated locations for XP_006527799.1

      UniProtKB/Swiss-Prot
      A2ALY1, Q6PG10, Q8BXH6, Q8CGY8, Q91Y38
      Conserved Domains (3) summary
      TIGR02917
      Location:22465
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:327355
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:5561024
      Glyco_transf_41; Glycosyl transferase family 41
    2. XM_011247503.2XP_011245805.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2

      See identical proteins and their annotated locations for XP_011245805.1

      UniProtKB/Swiss-Prot
      Q8CGY8
      Related
      ENSMUSP00000113454.2, ENSMUST00000119299.8
      Conserved Domains (3) summary
      TIGR02917
      Location:23455
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:317345
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:5461014
      Glyco_transf_41; Glycosyl transferase family 41
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