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    Btbd2 BTB domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 208198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btbd2provided by MGI
    Official Full Name
    BTB domain containing 2provided by MGI
    Primary source
    MGI:MGI:1933831
    See related
    Ensembl:ENSMUSG00000003344 AllianceGenome:MGI:1933831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610037C03Rik; 4930512K17Rik
    Summary
    Predicted to be involved in neurogenesis. Predicted to be active in P-body and cytosol. Orthologous to human BTBD2 (BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 45.6), ovary adult (RPKM 43.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Btbd2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80478457..80492328, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80642623..80656494, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 4 Neighboring gene predicted gene, 31298 Neighboring gene casein kinase 1, gamma 2 Neighboring gene predicted gene, 51810 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene MAP kinase-interacting serine/threonine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80141015-80141203 Neighboring gene MOB kinase activator 3A Neighboring gene STARR-positive B cell enhancer ABC_E6884

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. Carim-Todd L, et al. Gene, 2001 Jan 10. PMID 11179693
    2. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Xu L, et al. Exp Cell Res, 2003 Aug 1. PMID 12878161
    3. DNMT1 interacts with the developmental transcriptional repressor HESX1. Sajedi E, et al. Biochim Biophys Acta, 2008 Jan. PMID 17931718, Free PMC Article
    4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 2
    Names
    BTB (POZ) domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379084.1 → NP_001366013.1  BTB/POZ domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC152410
      Conserved Domains (3) summary
      cd18281
      Location:78 → 204
      BTB_POZ_BTBD1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2
      cd18523
      Location:200 → 305
      BACK_BTBD2; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2)
      pfam08005
      Location:364 → 513
      PHR; PHR domain

    2. NM_145361.3 → NP_663336.3  BTB/POZ domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152410
      Consensus CDS
      CCDS48639.1
      UniProtKB/TrEMBL
      E9PY28
      Related
      ENSMUSP00000120751.2, ENSMUST00000126980.8
      Conserved Domains (3) summary
      cd18281
      Location:78 → 204
      BTB_POZ_BTBD1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2
      cd18523
      Location:200 → 305
      BACK_BTBD2; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2)
      pfam08005
      Location:358 → 507
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80478457..80492328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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