U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Myb myeloblastosis oncogene [ Mus musculus (house mouse) ]

    Gene ID: 17863, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mybprovided by MGI
    Official Full Name
    myeloblastosis oncogeneprovided by MGI
    Primary source
    MGI:MGI:97249
    See related
    Ensembl:ENSMUSG00000019982 AllianceGenome:MGI:97249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c-myb
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to cytokine stimulus; hematopoietic or lymphoid organ development; and hemopoiesis. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study essential thrombocythemia and myelofibrosis. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 78.6), liver E14 (RPKM 10.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myb in Genome Data Viewer
    Location:
    10 A3; 10 9.75 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (21000829..21036883, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (21124930..21160984, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53617 Neighboring gene ribosomal protein S2, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_25971 Neighboring gene STARR-positive B cell enhancer ABC_E2930 Neighboring gene Abelson helper integration site 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20715221-20715330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20768493-20768817 Neighboring gene STARR-seq mESC enhancer starr_25973 Neighboring gene predicted gene, 20149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20812313-20812607 Neighboring gene STARR-seq mESC enhancer starr_25978 Neighboring gene STARR-seq mESC enhancer starr_25982 Neighboring gene STARR-seq mESC enhancer starr_25983 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:20906641-20906824 Neighboring gene predicted gene, 40608 Neighboring gene predicted gene, 33619

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC18531

    Gene Ontology Provided by MGI

    Items 1 - 25 of 38
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation PubMed 
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle PubMed 
    involved_in T-helper 2 cell differentiation  
    acts_upstream_of_or_within calcium ion transport PubMed 
    acts_upstream_of_or_within cellular response to interleukin-6 PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    acts_upstream_of_or_within embryonic digestive tract development PubMed 
    involved_in erythrocyte differentiation  
    acts_upstream_of_or_within homeostasis of number of cells PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in mitotic cell cycle  
    involved_in myeloid cell development PubMed 
    acts_upstream_of_or_within myeloid cell differentiation PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of hematopoietic progenitor cell differentiation  
    involved_in negative regulation of megakaryocyte differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of hepatic stellate cell activation  
    involved_in positive regulation of hepatic stellate cell proliferation  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of testosterone secretion  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transforming growth factor beta production  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within spleen development PubMed 
    acts_upstream_of_or_within stem cell division PubMed 
    acts_upstream_of_or_within thymus development PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex PubMed 
    part_of RNA polymerase II transcription regulator complex  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    transcriptional activator Myb
    Names
    gag-myb protein
    myb proto-oncogene protein
    myeloblastosis proto-oncogene product
    proto-oncogene c-Myb
    tumor-specific myb protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198914.2NP_001185843.1  transcriptional activator Myb isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC153556
      Consensus CDS
      CCDS78800.1
      UniProtKB/TrEMBL
      A0A087WPA7, Q8BU17
      Related
      ENSMUSP00000139699.2, ENSMUST00000188495.8
      Conserved Domains (4) summary
      smart00717
      Location:92140
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:92138
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:269313
      LMSTEN; LMSTEN motif
      pfam09316
      Location:516677
      Cmyb_C; C-myb, C-terminal
    2. NM_010848.3NP_034978.3  transcriptional activator Myb isoform 2

      See identical proteins and their annotated locations for NP_034978.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AA170760, AC153556, AK132250, AK137794, AK137965, BB543454, M12848
      Consensus CDS
      CCDS35861.1
      UniProtKB/Swiss-Prot
      E9QMG8, P06876, Q61929
      UniProtKB/TrEMBL
      Q61421
      Related
      ENSMUSP00000020158.7, ENSMUST00000020158.9
      Conserved Domains (4) summary
      smart00717
      Location:92140
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:92138
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam07988
      Location:269313
      LMSTEN; LMSTEN motif
      pfam09316
      Location:401558
      Cmyb_C; C-myb, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      21000829..21036883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    External link. Please review our privacy policy.