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Zfp292 zinc finger protein 292 [ Mus musculus (house mouse) ]

Gene ID: 30046, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp292provided by MGI
Official Full Name
zinc finger protein 292provided by MGI
Primary source
MGI:MGI:1353423
See related
Ensembl:ENSMUSG00000039967 AllianceGenome:MGI:1353423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp15; Zn-15; Zn-16; Zfp-15; Krox-10; mKIAA0530; 5730450D02Rik; 5830493J20Rik; 9430062L07Rik
Summary
Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human ZNF292 (zinc finger protein 292). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 6.0), CNS E14 (RPKM 5.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp292 in Genome Data Viewer
Location:
4 A5; 4 16.86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34803110..34882982, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34803110..34882983, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09916 Neighboring gene STARR-seq mESC enhancer starr_09917 Neighboring gene small integral membrane protein 8 Neighboring gene predicted gene, 57497 Neighboring gene STARR-positive B cell enhancer mm9_chr4:34767165-34767465 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09922 Neighboring gene STARR-seq mESC enhancer starr_09925 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34833884-34833993 Neighboring gene STARR-seq mESC enhancer starr_09928 Neighboring gene STARR-seq mESC enhancer starr_09932 Neighboring gene glycoprotein hormones, alpha subunit Neighboring gene pluripotency associated transcript 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo. Wojtkiewicz PW, et al. Endocrine, 2002 Jun. PMID 12166626
  2. Growth hormone transcription factor ZN-16 genomic coding regions are composed of a single exon and are evolutionarily conserved in mammals. Flynn MP, et al. Gene, 2006 Mar 1. PMID 16303260
  3. Mouse growth hormone transcription factor Zn-16: unique bipartite structure containing tandemly repeated zinc finger domains not reported in rat Zn-15. VanderHeyden TC, et al. Mol Cell Endocrinol, 2000 Jan 25. PMID 10687855
  4. Chromosomal localization of the zinc finger protein 15, Zfp15, on mouse chromosome 4. Roller ML, et al. Mamm Genome, 1995 Apr. PMID 7613041
  5. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
    Title: Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.
  2. first in vivo evidence that Zn-16 mRNA abundance correlates with growth hormone expression
    Title: Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 292
Names
zinc finger protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429838.1 → NP_001416767.1  zinc finger protein 292 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX465850, BX649603

  2. NM_013889.3 → NP_038917.2  zinc finger protein 292 isoform 1

    See identical proteins and their annotated locations for NP_038917.2

    Status: VALIDATED

    Source sequence(s)
    BX465850, BX649603
    Consensus CDS
    CCDS51138.1
    UniProtKB/Swiss-Prot
    B1B0E1, B1B0E2, Q8BQX3, Q8BS87, Q8CGI6, Q922D3, Q9Z2U2
    Related
    ENSMUSP00000037233.6, ENSMUST00000047950.6
    Conserved Domains (3) summary
    COG5189
    Location:1758 → 1944
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:724 → 744
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:542 → 561
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34803110..34882982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164179.1 → XP_036020072.1  zinc finger protein 292 isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:1736 → 1922
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:702 → 722
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:520 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036164180.1 → XP_036020073.1  zinc finger protein 292 isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:1736 → 1922
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:702 → 722
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:520 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036164181.1 → XP_036020074.1  zinc finger protein 292 isoform X2

    UniProtKB/TrEMBL
    Q8CHF2
    Conserved Domains (1) summary
    sd00017
    Location:734 → 757
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006537978.5 → XP_006538041.1  zinc finger protein 292 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:567 → 743
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:724 → 744
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:542 → 561
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2U2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2U2

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