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    TLR1 toll like receptor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574289, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLR1provided by VGNC
    Official Full Name
    toll like receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:78372
    See related
    Ensembl:ENSMMUG00000016754
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TLR1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (37935710..37945703, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (38445307..38454859, complement)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678153 Neighboring gene toll like receptor 10 Neighboring gene toll like receptor 6 Neighboring gene family with sequence similarity 114 member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis. Bernardino AL, et al. Infect Immun, 2008 Oct. PMID 18694963, Free PMC Article
    2. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
    3. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
    4. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.
      Title: Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Toll-like receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopeptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to triacyl bacterial lipopeptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Toll-like receptor 1-Toll-like receptor 2 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 1
    NP_001123896.1
    XP_028703759.1
    XP_028703760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130424.1 → NP_001123896.1  toll-like receptor 1 precursor

      See identical proteins and their annotated locations for NP_001123896.1

      Status: PROVISIONAL

      Source sequence(s)
      AB445623
      UniProtKB/TrEMBL
      B3Y611, B6CJY6, G7MSR1
      Conserved Domains (6) summary
      smart00082
      Location:524 → 577
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:636 → 779
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:353 → 474
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:47 → 70
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:352 → 373
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 124
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      37935710..37945703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028847927.1 → XP_028703760.1  toll-like receptor 1 isoform X1

      UniProtKB/TrEMBL
      B6CJY6, F7AIC3
      Conserved Domains (7) summary
      smart00082
      Location:524 → 577
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:636 → 779
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:352 → 560
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:12 → 268
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:47 → 70
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:352 → 373
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:70 → 124
      LRR_8; Leucine rich repeat

    2. XM_028847926.1 → XP_028703759.1  toll-like receptor 1 isoform X1

      UniProtKB/TrEMBL
      B6CJY6, F7AIC3
      Related
      ENSMMUP00000078776.1, ENSMMUT00000098521.1
      Conserved Domains (7) summary
      smart00082
      Location:524 → 577
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:636 → 779
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:352 → 560
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:12 → 268
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:47 → 70
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:352 → 373
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:70 → 124
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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