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Conserved domains on  [gi|1622936533|ref|XP_028703760|]
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toll-like receptor 1 isoform X1 [Macaca mulatta]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 7.25e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 146.31  E-value: 7.25e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622936533  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKNLMaRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 4.82e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSK-IAEMTtrmkSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNM 430
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEpLGNLT----NLKSLDLSNNQLTDlPEELGNL---TNLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 431 SSNILTD---TIFKClpPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSa 507
Cdd:COG4886   190 SNNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP- 266

                         170
                  ....*....|....*....
gi 1622936533 508 dFFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 -PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 5.09e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  32 SKNSLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNRLQYLDISVFKFNQeLEYLDLSHNKLAKIs 109
Cdd:COG4886   167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSTVLPIAHLNISKVLLVLGEHYGDKEDPEG 183
Cdd:COG4886   244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 184 LQNFNTESLHIVFPTSKEFNFILDVSVRTVANLELSNIKCVLEDNECSYFLNILAKLQTNPKLSSLTLNNIETTWNSFIR 263
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                         250
                  ....*....|
gi 1622936533 264 ILQLVWHTTV 273
Cdd:COG4886   402 LLTLALLDAV 411
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 3.87e-10

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 55.90  E-value: 3.87e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622936533  524 NPFQCTCELREFVKNIEQvssEVVEGWPDSYKCDYPESYRGtPLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 7.25e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 146.31  E-value: 7.25e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622936533  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKNLMaRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 5.66e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 98.98  E-value: 5.66e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKNLMARRTYLEWPKE----------KSKH--GLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIAYDIS 159


                  ....
gi 1622936533 778 IKLT 781
Cdd:pfam01582 160 NKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 4.82e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSK-IAEMTtrmkSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNM 430
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEpLGNLT----NLKSLDLSNNQLTDlPEELGNL---TNLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 431 SSNILTD---TIFKClpPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSa 507
Cdd:COG4886   190 SNNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP- 266

                         170
                  ....*....|....*....
gi 1622936533 508 dFFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 -PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 5.09e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  32 SKNSLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNRLQYLDISVFKFNQeLEYLDLSHNKLAKIs 109
Cdd:COG4886   167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSTVLPIAHLNISKVLLVLGEHYGDKEDPEG 183
Cdd:COG4886   244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 184 LQNFNTESLHIVFPTSKEFNFILDVSVRTVANLELSNIKCVLEDNECSYFLNILAKLQTNPKLSSLTLNNIETTWNSFIR 263
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                         250
                  ....*....|
gi 1622936533 264 ILQLVWHTTV 273
Cdd:COG4886   402 LLTLALLDAV 411
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 3.87e-10

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 55.90  E-value: 3.87e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622936533  524 NPFQCTCELREFVKNIEQvssEVVEGWPDSYKCDYPESYRGtPLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 6.18e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTRMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 432 SNILTDTIFKCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622936533 507 ADFFQSCQKMRSIKAGNNPFqcTCEL-REFVK----NIEQVSSEVVEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
69-126 1.45e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.45e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622936533  69 SKLRILIISHNRLQYLDISVFKFNQELEYLDLSHNKLAKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 2.72e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTRMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622936533 423 KSLLSLNMSSNILTDTIFKCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-435 5.89e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 5.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  50 LNISQNYISELWTSDILSLSKLRILIISHN--------------RLQYLDISVFKFN----------QELEYLDLSHNKL 105
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltnltSLEFLTLASNQLVgqiprelgqmKSLKWIYLGYNNL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 106 A---KISCHPTVNLKHLDLSFNAFDAlPICKEFGNMSQLKFLGLSTTHLekSTVLPIAHLNISKVL-LVLGEHYGDKEDP 181
Cdd:PLN00113  225 SgeiPYEIGGLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKL--SGPIPPSIFSLQKLIsLDLSDNSLSGEIP 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 182 EGL-QNFNTESLHIVfptSKEFNFILDVSVR-----------------------------TVANLELSNIKCVLEDNECS 231
Cdd:PLN00113  302 ELViQLQNLEILHLF---SNNFTGKIPVALTslprlqvlqlwsnkfsgeipknlgkhnnlTVLDLSTNNLTGEIPEGLCS 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 232 --------YFLNILAKlQTNPKLSS--------LTLNNIETTWNSFIRILQLVWhttvrYFSISNVKLQGQLDFRDFDYS 295
Cdd:PLN00113  379 sgnlfkliLFSNSLEG-EIPKSLGAcrslrrvrLQDNSFSGELPSEFTKLPLVY-----FLDISNNNLQGRINSRKWDMP 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 296 GTSLKALSVHQVVSdvfNFPQrdiyeIFSNMNIRNFTVSGTRMIHMVcPSK---ISPFLHLDFSNNLLTDTVFENCGHLT 372
Cdd:PLN00113  453 SLQMLSLARNKFFG---GLPD-----SFGSKRLENLDLSRNQFSGAV-PRKlgsLSELMQLKLSENKLSGEIPDELSSCK 523

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622936533 373 ELETLILQMNQLKelSKIAEMTTRMKSLQQLDISQNSVSYDEKKgDCSWTKSLLSLNMSSNIL 435
Cdd:PLN00113  524 KLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEIPK-NLGNVESLVQVNISHNHL 583
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.33e-04

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 39.34  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*
gi 1622936533 553 SYKCDYPESYRGTPLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
LRR_8 pfam13855
Leucine rich repeat;
445-500 1.88e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 20-109 2.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  20 QLSEESEFLVD-RSKNSLihvpkdlSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRLQYLD--ISVFKFNQELE 96
Cdd:cd21340   101 RLPPGEKLTFDpRSLAAL-------SNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLR 171

                          90
                  ....*....|...
gi 1622936533  97 YLDLSHNKLAKIS 109
Cdd:cd21340   172 ELDLTGNPVCKKP 184
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 497-578 2.99e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.22  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  497 IDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCTCELREFVKNIEQVSSEVVEgwPDSYKCDYPESYRGTPLKDFHMSELS 576
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQ--PEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 1622936533  577 CN 578
Cdd:TIGR00864   80 CD 81
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-526 6.30e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  44 SQKTTILNISQNYISELWTSDILSLSKLRILIISHNRLQY-LDISVFKFNQELEYLDLSHNKLA-KISCHPTVNLKHLDL 121
Cdd:PLN00113   68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 122 SFNAFDAlPICKEFGNMSQLKFLGLSTTHLEKStvLPIAHLNISKvllvlgehygdkedpegLQNFNTESLHIVFPTSKE 201
Cdd:PLN00113  148 SNNMLSG-EIPNDIGSFSSLKVLDLGGNVLVGK--IPNSLTNLTS-----------------LEFLTLASNQLVGQIPRE 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 202 FNfildvsvrtvanlELSNIKCV-LEDNECSYFLNIlaklqtnpKLSSLT-LNNIETTWNSFIRIL--QLVWHTTVRYFS 277
Cdd:PLN00113  208 LG-------------QMKSLKWIyLGYNNLSGEIPY--------EIGGLTsLNHLDLVYNNLTGPIpsSLGNLKNLQYLF 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 278 ISNVKLQGQ-------------LDFRDFDYSG------TSLKALSVHQVVSDVF---------NFPQRDIYEIFSNmnir 329
Cdd:PLN00113  267 LYQNKLSGPippsifslqklisLDLSDNSLSGeipelvIQLQNLEILHLFSNNFtgkipvaltSLPRLQVLQLWSN---- 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 330 NFTVSGTRMIhmvcpSKISPFLHLDFSNNLLTDTVFE---NCGHLTELetlILQMNQLKelSKIAEMTTRMKSLQQLDIS 406
Cdd:PLN00113  343 KFSGEIPKNL-----GKHNNLTVLDLSTNNLTGEIPEglcSSGNLFKL---ILFSNSLE--GEIPKSLGACRSLRRVRLQ 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 407 QNSVSYDEKKGdcsWTKSLLS--LNMSSNILTDTI--FKCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTD 482
Cdd:PLN00113  413 DNSFSGELPSE---FTKLPLVyfLDISNNNLQGRInsRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSG 489

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1622936533 483 -LP-GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGNNPF 526
Cdd:PLN00113  490 aVPrKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 7.25e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 146.31  E-value: 7.25e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622936533  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKNLMaRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 5.66e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 98.98  E-value: 5.66e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKNLMARRTYLEWPKE----------KSKH--GLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIAYDIS 159


                  ....
gi 1622936533 778 IKLT 781
Cdd:pfam01582 160 NKLN 163
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 640-733 1.65e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 640 FISYSGHDSFWVKnELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 719
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 1622936533 720 HEGSNNLILILLEP 733
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 4.82e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSK-IAEMTtrmkSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNM 430
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEpLGNLT----NLKSLDLSNNQLTDlPEELGNL---TNLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 431 SSNILTD---TIFKClpPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSa 507
Cdd:COG4886   190 SNNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP- 266

                         170
                  ....*....|....*....
gi 1622936533 508 dFFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 -PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
235-541 4.18e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 235 NILAKLQTNPKLSSLTLNNIETTWNSFIRILQLVWHTTVRYFSISNVKLQGQLDFRDFDYSGTSLKALSVHQVVSdVFNF 314
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN-LTEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 315 PQRDIYEIFSNMNIRNFTVSGTRMIHMvcPSKISPFLHL---DFSNNLLTDtVFENCGHLTELETLILQMNQLKELSKIA 391
Cdd:COG4886   102 DLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 392 EmttRMKSLQQLDISQNSVSydEKKGDCSWTKSLLSLNMSSNILTD---TIFKClpPRIKVLDLHSNKIKSIPkQVVKLE 468
Cdd:COG4886   179 G---NLTNLKELDLSNNQIT--DLPEPLGNLTNLEELDLSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLT 250

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622936533 469 ALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCTCELREFVKNIEQ 541
Cdd:COG4886   251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 5.09e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  32 SKNSLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNRLQYLDISVFKFNQeLEYLDLSHNKLAKIs 109
Cdd:COG4886   167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSTVLPIAHLNISKVLLVLGEHYGDKEDPEG 183
Cdd:COG4886   244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 184 LQNFNTESLHIVFPTSKEFNFILDVSVRTVANLELSNIKCVLEDNECSYFLNILAKLQTNPKLSSLTLNNIETTWNSFIR 263
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                         250
                  ....*....|
gi 1622936533 264 ILQLVWHTTV 273
Cdd:COG4886   402 LLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-152 1.66e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  45 QKTTILNISQNYISELwTSDILSLSKLRILIISHNRLQYLDISVFKFNQeLEYLDLSHNKLAKISCH--PTVNLKHLDLS 122
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLS 190

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622936533 123 FNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   191 NNQITDLP--EPLGNLTNLEELDLSGNQLT 218
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 3.87e-10

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 55.90  E-value: 3.87e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622936533  524 NPFQCTCELREFVKNIEQvssEVVEGWPDSYKCDYPESYRGtPLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 6.18e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTRMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 432 SNILTDTIFKCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622936533 507 ADFFQSCQKMRSIKAGNNPFqcTCEL-REFVK----NIEQVSSEVVEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
69-126 1.45e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.45e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622936533  69 SKLRILIISHNRLQYLDISVFKFNQELEYLDLSHNKLAKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 352-483 1.97e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 352 HLDFSNNLLTD----TVFENCGHLTELETLILQMNQLKE--LSKIAEMTTRMKSLQQLDISQNSVsydekkGDCSW---- 421
Cdd:COG5238   240 TLDLSNNQIGDegviALAEALKNNTTVETLYLSGNQIGAegAIALAKALQGNTTLTSLDLSVNRI------GDEGAiala 313

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622936533 422 -----TKSLLSLNMSSNILTDT----IFKCLP--PRIKVLDLHSNKI-----KSIPKQVVKLEALQELNVAFNSLTDL 483
Cdd:COG5238   314 eglqgNKTLHTLNLAYNGIGAQgaiaLAKALQenTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQ 391
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 2.72e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTRMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622936533 423 KSLLSLNMSSNILTDTIFKCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
344-484 2.83e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 344 PSKISPFLhLDfSNNLLT---------DTVFENCGHLTELETLILQMNQLKELS--KIAEMTTRMKS-LQQLDISQNSVS 411
Cdd:PRK15370  198 PEQITTLI-LD-NNELKSlpenlqgniKTLYANSNQLTSIPATLPDTIQEMELSinRITELPERLPSaLQSLDLFHNKIS 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 412 ---------------YDE--KKGDCSWTKSLLSLNMSSNILT----------------DTIFKCLP----PRIKVLDLHS 454
Cdd:PRK15370  276 clpenlpeelrylsvYDNsiRTLPAHLPSGITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSK 355

                         170       180       190
                  ....*....|....*....|....*....|
gi 1622936533 455 NKIKSIPKQVVKleALQELNVAFNSLTDLP 484
Cdd:PRK15370  356 NQITVLPETLPP--TITTLDVSRNALTNLP 383
LRR_8 pfam13855
Leucine rich repeat;
48-105 4.05e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622936533  48 TILNISQNYISELWTSDILSLSKLRILIISHNRLQYLDISVFKFNQELEYLDLSHNKL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-435 5.89e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 5.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  50 LNISQNYISELWTSDILSLSKLRILIISHN--------------RLQYLDISVFKFN----------QELEYLDLSHNKL 105
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnsltnltSLEFLTLASNQLVgqiprelgqmKSLKWIYLGYNNL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 106 A---KISCHPTVNLKHLDLSFNAFDAlPICKEFGNMSQLKFLGLSTTHLekSTVLPIAHLNISKVL-LVLGEHYGDKEDP 181
Cdd:PLN00113  225 SgeiPYEIGGLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKL--SGPIPPSIFSLQKLIsLDLSDNSLSGEIP 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 182 EGL-QNFNTESLHIVfptSKEFNFILDVSVR-----------------------------TVANLELSNIKCVLEDNECS 231
Cdd:PLN00113  302 ELViQLQNLEILHLF---SNNFTGKIPVALTslprlqvlqlwsnkfsgeipknlgkhnnlTVLDLSTNNLTGEIPEGLCS 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 232 --------YFLNILAKlQTNPKLSS--------LTLNNIETTWNSFIRILQLVWhttvrYFSISNVKLQGQLDFRDFDYS 295
Cdd:PLN00113  379 sgnlfkliLFSNSLEG-EIPKSLGAcrslrrvrLQDNSFSGELPSEFTKLPLVY-----FLDISNNNLQGRINSRKWDMP 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 296 GTSLKALSVHQVVSdvfNFPQrdiyeIFSNMNIRNFTVSGTRMIHMVcPSK---ISPFLHLDFSNNLLTDTVFENCGHLT 372
Cdd:PLN00113  453 SLQMLSLARNKFFG---GLPD-----SFGSKRLENLDLSRNQFSGAV-PRKlgsLSELMQLKLSENKLSGEIPDELSSCK 523

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622936533 373 ELETLILQMNQLKelSKIAEMTTRMKSLQQLDISQNSVSYDEKKgDCSWTKSLLSLNMSSNIL 435
Cdd:PLN00113  524 KLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEIPK-NLGNVESLVQVNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 6.00e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533   2 TSIFHFAIIFMLTLQIRIQLSEESEFLVDRSKNSLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRL 81
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622936533  82 qyldisvFKFNQELEYLDLSHNKLAKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   109 -------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 7.90e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 7.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  33 KNSLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRLQYLDISVfkfNQELEYLDLSHNKLAKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1622936533 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.33e-04

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 39.34  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*
gi 1622936533 553 SYKCDYPESYRGTPLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
LRR_8 pfam13855
Leucine rich repeat;
445-500 1.88e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 20-109 2.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  20 QLSEESEFLVD-RSKNSLihvpkdlSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRLQYLD--ISVFKFNQELE 96
Cdd:cd21340   101 RLPPGEKLTFDpRSLAAL-------SNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLR 171

                          90
                  ....*....|...
gi 1622936533  97 YLDLSHNKLAKIS 109
Cdd:cd21340   172 ELDLTGNPVCKKP 184
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 497-578 2.99e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.22  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  497 IDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCTCELREFVKNIEQVSSEVVEgwPDSYKCDYPESYRGTPLKDFHMSELS 576
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQ--PEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 1622936533  577 CN 578
Cdd:TIGR00864   80 CD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-411 3.30e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 352 HLDFSNNLLTDTvfENCGHLTELETLILQMNQLKELSKIAEMTTRMKSLQQLDISQNSVS 411
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-526 6.30e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533  44 SQKTTILNISQNYISELWTSDILSLSKLRILIISHNRLQY-LDISVFKFNQELEYLDLSHNKLA-KISCHPTVNLKHLDL 121
Cdd:PLN00113   68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 122 SFNAFDAlPICKEFGNMSQLKFLGLSTTHLEKStvLPIAHLNISKvllvlgehygdkedpegLQNFNTESLHIVFPTSKE 201
Cdd:PLN00113  148 SNNMLSG-EIPNDIGSFSSLKVLDLGGNVLVGK--IPNSLTNLTS-----------------LEFLTLASNQLVGQIPRE 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 202 FNfildvsvrtvanlELSNIKCV-LEDNECSYFLNIlaklqtnpKLSSLT-LNNIETTWNSFIRIL--QLVWHTTVRYFS 277
Cdd:PLN00113  208 LG-------------QMKSLKWIyLGYNNLSGEIPY--------EIGGLTsLNHLDLVYNNLTGPIpsSLGNLKNLQYLF 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 278 ISNVKLQGQ-------------LDFRDFDYSG------TSLKALSVHQVVSDVF---------NFPQRDIYEIFSNmnir 329
Cdd:PLN00113  267 LYQNKLSGPippsifslqklisLDLSDNSLSGeipelvIQLQNLEILHLFSNNFtgkipvaltSLPRLQVLQLWSN---- 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 330 NFTVSGTRMIhmvcpSKISPFLHLDFSNNLLTDTVFE---NCGHLTELetlILQMNQLKelSKIAEMTTRMKSLQQLDIS 406
Cdd:PLN00113  343 KFSGEIPKNL-----GKHNNLTVLDLSTNNLTGEIPEglcSSGNLFKL---ILFSNSLE--GEIPKSLGACRSLRRVRLQ 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622936533 407 QNSVSYDEKKGdcsWTKSLLS--LNMSSNILTDTI--FKCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTD 482
Cdd:PLN00113  413 DNSFSGELPSE---FTKLPLVyfLDISNNNLQGRInsRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSG 489

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1622936533 483 -LP-GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGNNPF 526
Cdd:PLN00113  490 aVPrKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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