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    Nlrc5 NLR family, CARD domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291861, updated on 9-Dec-2024

    Summary

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    Symbol
    Nlrc5provided by RGD
    Full Name
    NLR family, CARD domain containing 5provided by RGD
    Primary source
    RGD:1309166
    See related
    EnsemblRapid:ENSRNOG00000048222 AllianceGenome:RGD:1309166
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cpne2
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including innate immune response; regulation of cytokine-mediated signaling pathway; and regulation of macromolecule biosynthetic process. Predicted to act upstream of or within response to bacterium. Predicted to be located in centrosome; cytosol; and nucleus. Orthologous to human NLRC5 (NLR family CARD domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 83.8), Thymus (RPKM 74.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nlrc5 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10483601..10587223, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10477638..10581023, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10904381..11006202, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483687 Neighboring gene copine 2 Neighboring gene uncharacterized LOC134483689 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC134483688 Neighboring gene homocysteine inducible ER protein with ubiquitin like domain 1 Neighboring gene uncharacterized LOC102553339 Neighboring gene uncharacterized LOC120098571 Neighboring gene solute carrier family 12 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. Liu YR, et al. J Cell Physiol, 2019 Aug. PMID 30644097
    2. NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis. Liu YR, et al. Mol Immunol, 2017 Nov. PMID 28865311
    3. NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway. Zhou H, et al. Mol Med Rep, 2017 Sep. PMID 28713900
    4. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. Kuenzel S, et al. J Immunol, 2010 Feb 15. PMID 20061403
    5. NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway. Li L, et al. J Recept Signal Transduct Res, 2021 Feb. PMID 32605461

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway.
      Title: NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway.
    2. The level of MEG3 significantly reduced in CFA-induced synovial tissues and Fibroblast-like synoviocytes (FLSs), whereas the NLRC5 levels were increased. Enforced expression of MEG3 may be responsible for the decreased level of NLRC5 and inflammatory cytokine level
      Title: Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5.
    3. NLRC5 silencing ameliorated cardiac fibrosis by inhibiting the TGFbeta1/Smad3 signaling pathway.
      Title: NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway.
    4. These results suggested that NLRC5 promotes Rheumatoid arthritis progression via the NF-kappaB signaling pathway potentially.
      Title: NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MHC class I biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MHC class I biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NLR family, CARD domain containing 5; protein NLRC5
    Names
    copine II
    protein NLRC5-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10483601..10587223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098152.2 → XP_038954080.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_039098155.2 → XP_038954083.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_039098156.2 → XP_038954084.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. XM_039098158.2 → XP_038954086.1  protein NLRC5 isoform X3

      Related
      ENSRNOP00000107072.1, ENSRNOT00000160769.1
      Conserved Domains (6) summary
      sd00033
      Location:1470 → 1497
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1386 → 1410
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1441 → 1751
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    5. XM_039098157.2 → XP_038954085.1  protein NLRC5 isoform X2

      Related
      ENSRNOP00000064308.4, ENSRNOT00000073239.4
      Conserved Domains (6) summary
      sd00033
      Location:1498 → 1525
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1414 → 1438
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1469 → 1779
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    6. XM_039098150.2 → XP_038954078.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    7. XM_039098154.2 → XP_038954082.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    8. XM_039098153.2 → XP_038954081.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Conserved Domains (6) summary
      sd00033
      Location:1526 → 1553
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1442 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:224 → 387
      NACHT; NACHT domain
      pfam17776
      Location:520 → 635
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 94
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1497 → 1807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    9. XM_063278888.1 → XP_063134958.1  protein NLRC5 isoform X1

      UniProtKB/TrEMBL
      M0R4M1
      Related
      ENSRNOP00000111243.1, ENSRNOT00000142811.1

    10. XM_063278889.1 → XP_063134959.1  protein NLRC5 isoform X4

    RNA

    1. XR_005496893.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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