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    Man2b1 mannosidase 2, alpha B1 [ Mus musculus (house mouse) ]

    Gene ID: 17159, updated on 9-Dec-2024

    Summary

    Official Symbol
    Man2b1provided by MGI
    Official Full Name
    mannosidase 2, alpha B1provided by MGI
    Primary source
    MGI:MGI:107286
    See related
    Ensembl:ENSMUSG00000005142 AllianceGenome:MGI:107286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAMAN
    Summary
    Enables alpha-mannosidase activity. Involved in oligosaccharide catabolic process. Acts upstream of or within learning or memory and mannose metabolic process. Is active in lysosomal lumen. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study alpha-mannosidosis. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 43.7), spleen adult (RPKM 42.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Man2b1 in Genome Data Viewer
    Location:
    8 C3; 8 41.55 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85809941..85824215)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85082730..85098739)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene deoxyhypusine synthase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87604516-87604669 Neighboring gene WD repeat domain containing 83 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene zinc finger protein 791 Neighboring gene predicted gene, 42031

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding  
    enables D-mannose binding  
    enables alpha-mannosidase activity  
    enables alpha-mannosidase activity PubMed 
    enables alpha-mannosidase activity PubMed 
    enables alpha-mannosidase activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    is_active_in lysosomal lumen PubMed 
    is_active_in lysosome  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    lysosomal alpha-mannosidase
    Names
    lysosomal acid alpha-mannosidase
    mannosidase alpha class 2B member 1
    mannosidase alpha-B
    NP_001411770.1
    NP_001411771.1
    NP_001411772.1
    NP_034894.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424841.1NP_001411770.1  lysosomal alpha-mannosidase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3TBM1
    2. NM_001424842.1NP_001411771.1  lysosomal alpha-mannosidase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3TBM1
    3. NM_001424843.1NP_001411772.1  lysosomal alpha-mannosidase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      Q3TBM1
    4. NM_010764.3NP_034894.2  lysosomal alpha-mannosidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_034894.2

      Status: VALIDATED

      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS22494.1
      UniProtKB/Swiss-Prot
      O09159, O55037, Q3UGH3, Q64443, Q9DBQ1
      UniProtKB/TrEMBL
      Q3TBM1
      Related
      ENSMUSP00000034121.10, ENSMUST00000034121.11
      Conserved Domains (3) summary
      cd10810
      Location:63341
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:387465
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:5101001
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85809941..85824215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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