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    St6galnac6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 50935, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St6galnac6provided by MGI
    Official Full Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6provided by MGI
    Primary source
    MGI:MGI:1355316
    See related
    Ensembl:ENSMUSG00000026811 AllianceGenome:MGI:1355316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat7f; ST6GalNAcVI
    Summary
    Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in oligosaccharide biosynthetic process. Acts upstream of or within ganglioside biosynthetic process. Located in cytoplasm. Is expressed in alimentary system; axial muscle; brain; craniocervical region bone; and exocrine system. Orthologous to human ST6GALNAC6 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 299.0), adrenal adult (RPKM 26.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St6galnac6 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32489721..32510821)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32599709..32620809)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10095 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369 Neighboring gene STARR-positive B cell enhancer ABC_E10096 Neighboring gene STARR-seq mESC enhancer starr_04202 Neighboring gene adenylate kinase 1 Neighboring gene STARR-seq mESC enhancer starr_04203 Neighboring gene microRNA 1954 Neighboring gene endoglin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the genomic structures and promoter activities of mouse Siaalpha2,3Galbeta1,3GalNAc GalNAcalpha2, 6-sialyltransferase genes (ST6GalNAc III and IV): characterization of their Sp1 binding sites. Takashima S, et al. J Biochem, 2000 Mar. PMID 10731711
    2. Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon. Taniguchi M, et al. Mucosal Immunol, 2023 Oct. PMID 37385587
    3. Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene. Okajima T, et al. J Biol Chem, 2000 Mar 10. PMID 10702226
    4. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Tsuchida A, et al. J Biol Chem, 2003 Jun 20. PMID 12668675
    5. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. Ngamukote S, et al. J Neurochem, 2007 Dec. PMID 17883393

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell recognition IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ganglioside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosylceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    Names
    (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    galNAc alpha-2,6-sialyltransferase VI
    sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F
    NP_001020481.1
    NP_001020482.1
    NP_001276476.1
    NP_001276477.1
    NP_001276478.1
    NP_058669.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025310.2 → NP_001020481.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001020481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and uses an alternate splice splice site in the 3' terminal exon, compared to variant 4. This results in a frameshift and an early stop codon, compared to variant 4. Variants 2 and 6 encode the same isoform (2), which is shorter and has a distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AB035123, AK030648, AK159158, BY072844
      Consensus CDS
      CCDS38105.1
      UniProtKB/TrEMBL
      E9PU98, E9PUI0
      Related
      ENSMUSP00000108915.2, ENSMUST00000113290.8
      Conserved Domains (1) summary
      pfam00777
      Location:68 → 289
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001025311.2 → NP_001020482.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon structure and uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 4. It encodes isoform 3, which is shorter and has distinct N- and C-termini, compared to isoform 4.
      Source sequence(s)
      AB035123, AK030648, AK159158, BY720739
      Consensus CDS
      CCDS15922.1
      UniProtKB/TrEMBL
      Z4YLR0
      Related
      ENSMUSP00000115430.3, ENSMUST00000131229.8
      Conserved Domains (1) summary
      pfam00777
      Location:82 → 303
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001289547.1 → NP_001276476.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AB035123, AK030648, AK159158, BY072844
      UniProtKB/Swiss-Prot
      Q9JM95
      Conserved Domains (1) summary
      pfam00777
      Location:102 → 266
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_001289548.1 → NP_001276477.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 4. It encodes isoform 5, which has a shorter N-terminus, compared to isoform 4.
      Source sequence(s)
      AB035123, AK030648, AK159158, BY072844
      UniProtKB/Swiss-Prot
      Q9JM95
      Conserved Domains (1) summary
      pfam00777
      Location:68 → 232
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. NM_001289549.1 → NP_001276478.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and uses an alternate splice splice site in the 3' terminal exon, compared to variant 4. This results in a frameshift and an early stop codon, compared to variant 4. Variants 2 and 6 encode the same isoform (2), which is shorter and has a distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AB035123, AK030648, AK159158, BY072844, CK617550
      Consensus CDS
      CCDS38105.1
      UniProtKB/TrEMBL
      E9PU98, E9PUI0
      Related
      ENSMUSP00000092655.4, ENSMUST00000095045.9
      Conserved Domains (1) summary
      pfam00777
      Location:68 → 289
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. NM_016973.3 → NP_058669.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 1

      See identical proteins and their annotated locations for NP_058669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, compared to variant 4. This results in a frameshift and an early stop codon, compared to variant 4. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AB035123, AK030648, AK159158, BY072844
      Consensus CDS
      CCDS15923.1
      UniProtKB/Swiss-Prot
      A2AK72, A2AK76, A2AK77, A2AK78, A2AK79, Q05CN1, Q8CDC3, Q9JM95, Q9R0G9
      Related
      ENSMUSP00000092654.4, ENSMUST00000095044.10
      Conserved Domains (1) summary
      pfam00777
      Location:102 → 323
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_110347.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in an internal exon, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB035123, AK030648, AK159158, BY072844
      Related
      ENSMUST00000183538.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32489721..32510821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JM95.1 GenPept UniProtKB/Swiss-Prot:Q9JM95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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