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    Cd226 CD226 antigen [ Mus musculus (house mouse) ]

    Gene ID: 225825, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cd226provided by MGI
    Official Full Name
    CD226 antigenprovided by MGI
    Primary source
    MGI:MGI:3039602
    See related
    Ensembl:ENSMUSG00000034028 AllianceGenome:MGI:3039602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pta1; DNAM1; DNAM-1; TLiSA1
    Summary
    Predicted to enable identical protein binding activity; integrin binding activity; and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Cd226 in Genome Data Viewer
    Location:
    18 E4; 18 59.05 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (89195078..89290356)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (89176954..89272232)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 6 Neighboring gene STARR-positive B cell enhancer mm9_chr18:89141017-89141318 Neighboring gene microRNA 6359 Neighboring gene rotatin Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:89509927-89510110 Neighboring gene docking protein 6 Neighboring gene predicted gene, 18279 Neighboring gene STARR-seq mESC enhancer starr_45304 Neighboring gene predicted gene, 41800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. Sherrington PD, et al. J Biol Chem, 1997 Aug 29. PMID 9268302
    2. Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Guillerey C, et al. J Clin Invest, 2015 May. PMID 25893601, Free PMC Article
    3. Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. Lenac Rovis T, et al. J Exp Med, 2016 Aug 22. PMID 27503073, Free PMC Article
    4. Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity. Ramsbottom KM, et al. J Immunol, 2014 Jan 15. PMID 24337740
    5. Intranodal interaction with dendritic cells dynamically regulates surface expression of the co-stimulatory receptor CD226 protein on murine T cells. Seth S, et al. J Biol Chem, 2011 Nov 11. PMID 21937446, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model.
      Title: Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model.
    2. CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
      Title: CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
    3. Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer.
      Title: Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer.
    4. Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
      Title: Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
    5. CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
      Title: CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
    6. Ablation of CD226 on CD4[+] T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
      Title: Ablation of CD226 on CD4(+) T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
    7. CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes.
      Title: CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes.
    8. [Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine].
      Title: [Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine].
    9. [DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway].
      Title: [DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway].
    10. Loss of CD226 protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
      Title: Loss of CD226 protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of natural killer cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CD226 antigen
    Names
    platelet and T cell activation antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039149.1 → NP_001034238.1  CD226 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_001034238.1

      Status: VALIDATED

      Source sequence(s)
      AC116387, AF421199
      Consensus CDS
      CCDS29391.1
      UniProtKB/TrEMBL
      Q8K4E3
      Related
      ENSMUSP00000095104.3, ENSMUST00000097496.4
      Conserved Domains (2) summary
      smart00410
      Location:26 → 124
      IG_like; Immunoglobulin like
      cl11960
      Location:24 → 113
      Ig; Immunoglobulin domain

    2. NM_178687.2 → NP_848802.2  CD226 antigen isoform a precursor

      See identical proteins and their annotated locations for NP_848802.2

      Status: VALIDATED

      Source sequence(s)
      AC116387, AK140349
      Consensus CDS
      CCDS29392.1
      UniProtKB/Swiss-Prot
      Q8K4F0
      UniProtKB/TrEMBL
      Q5DW69
      Related
      ENSMUSP00000043551.6, ENSMUST00000037142.13
      Conserved Domains (3) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
      cl11960
      Location:137 → 225
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      89195078..89290356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526463.1 → XP_006526526.1  CD226 antigen isoform X4

      Conserved Domains (1) summary
      cl11960
      Location:21 → 110
      Ig; Immunoglobulin domain

    2. XM_006526461.1 → XP_006526524.1  CD226 antigen isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:52 → 149
      Ig; Immunoglobulin domain

    3. XM_017317894.1 → XP_017173383.1  CD226 antigen isoform X3

      Conserved Domains (1) summary
      cl11960
      Location:45 → 134
      Ig; Immunoglobulin domain

    4. XM_036161134.1 → XP_036017027.1  CD226 antigen isoform X2

      UniProtKB/Swiss-Prot
      Q8K4F0
      UniProtKB/TrEMBL
      Q5DW69
      Related
      ENSMUSP00000158324.2, ENSMUST00000236828.2
      Conserved Domains (3) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
      cl11960
      Location:137 → 225
      Ig; Immunoglobulin domain

    5. XM_006526464.5 → XP_006526527.1  CD226 antigen isoform X5

      See identical proteins and their annotated locations for XP_006526527.1

      UniProtKB/TrEMBL
      Q8K4E2
      Related
      ENSMUSP00000158239.2, ENSMUST00000236452.2

    6. XM_006526462.5 → XP_006526525.1  CD226 antigen isoform X2

      See identical proteins and their annotated locations for XP_006526525.1

      UniProtKB/Swiss-Prot
      Q8K4F0
      UniProtKB/TrEMBL
      Q5DW69
      Conserved Domains (3) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cd05889
      Location:17 → 128
      IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
      cl11960
      Location:137 → 225
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039148.1: Suppressed sequence

      Description
      NM_001039148.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4F0.1 GenPept UniProtKB/Swiss-Prot:Q8K4F0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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