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Conserved domains on  [gi|85540456|ref|NP_848802|]
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CD226 antigen isoform a precursor [Mus musculus]

Protein Classification

Ig1_DNAM-1_like and Ig domain-containing protein( domain architecture ID 10147264)

Ig1_DNAM-1_like and Ig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 17-128 6.64e-60

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


:

Pssm-ID: 409472  Cd Length: 111  Bit Score: 187.76  E-value: 6.64e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  17 LCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKnTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSF 96
Cdd:cd05889   1 LVEEVLWDTSVPLSENMSLECVYPSTGILTQVEWTK-IGGQKDNIAVYHPTHGMHIRKPYAGRVYFLNSTMASNNMSLSF 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 85540456  97 YNASEADIGIYSCLFHAFPNGPWEKKIKVVWS 128
Cdd:cd05889  80 RNASEDDVGYYSCSLYTYPQGSWEKVIQVVQS 111
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 137-225 3.78e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.14  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456   137 SDSYLSAEPGQDVTLTCQLPRTW--PVQQVIWEKVQP---HQVDILASCNLSQETRYTSKYlrqtRSNCSQGSMKSILII 211
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRF----SGRGDPSNGDGSLTI 77

                          90
                  ....*....|....
gi 85540456   212 PNAMAADSGLYRCR 225
Cdd:pfam07686  78 QNLTLSDSGTYTCA 91
 
Name Accession Description Interval E-value
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 17-128 6.64e-60

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 187.76  E-value: 6.64e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  17 LCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKnTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSF 96
Cdd:cd05889   1 LVEEVLWDTSVPLSENMSLECVYPSTGILTQVEWTK-IGGQKDNIAVYHPTHGMHIRKPYAGRVYFLNSTMASNNMSLSF 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 85540456  97 YNASEADIGIYSCLFHAFPNGPWEKKIKVVWS 128
Cdd:cd05889  80 RNASEDDVGYYSCSLYTYPQGSWEKVIQVVQS 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-125 2.01e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456    25 TTVRLSETMTLECVYPLTHNL--TQVEWTKNTGTK--TVSIAVYNPNHNMHIESNylhRVHfLNSTVGFRNMSLSFYNAS 100
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEasTSVYWYRQPPGKgpTFLIAYYSNGSEEGVKKG---RFS-GRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*
gi 85540456   101 EADIGIYSCLFHAFPNGPWEKKIKV 125
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVFGKGTRL 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 137-225 3.78e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.14  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456   137 SDSYLSAEPGQDVTLTCQLPRTW--PVQQVIWEKVQP---HQVDILASCNLSQETRYTSKYlrqtRSNCSQGSMKSILII 211
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRF----SGRGDPSNGDGSLTI 77

                          90
                  ....*....|....
gi 85540456   212 PNAMAADSGLYRCR 225
Cdd:pfam07686  78 QNLTLSDSGTYTCA 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 139-237 3.77e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456    139 SYLSAEPGQDVTLTCQLPRTwPVQQVIWEKVQPHQvdilascnLSQETRYTSkylrqtrsncSQGSMKSILIIPNAMAAD 218
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGS-PPPEVTWYKQGGKL--------LAESGRFSV----------SRSGSTSTLTISNVTPED 62

                           90
                   ....*....|....*....
gi 85540456    219 SGLYRCRSEAITGKNKSFV 237
Cdd:smart00410  63 SGTYTCAATNSSGSASSGT 81
IgI_3_Contactin cd04968
Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) ...
 130-234 1.59e-04

Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409357 [Multi-domain]  Cd Length: 88  Bit Score: 39.84  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456 130 SFEIAAPSDSYlsAEPGQDVTLTCqLPRTWPVQQVIWEKVQPHQVdilascnlSQETRYTSKylrqtrsncsqgsmkSIL 209
Cdd:cd04968   2 SIKVRFPADTY--ALKGQTVTLEC-FALGNPVPQIKWRKVDGSPS--------SQWEITTSE---------------PVL 55

                        90       100
                ....*....|....*....|....*
gi 85540456 210 IIPNAMAADSGLYRCRSEAITGKNK 234
Cdd:cd04968  56 EIPNVQFEDEGTYECEAENSRGKDT 80
 
Name Accession Description Interval E-value
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 17-128 6.64e-60

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 187.76  E-value: 6.64e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  17 LCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKnTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSF 96
Cdd:cd05889   1 LVEEVLWDTSVPLSENMSLECVYPSTGILTQVEWTK-IGGQKDNIAVYHPTHGMHIRKPYAGRVYFLNSTMASNNMSLSF 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 85540456  97 YNASEADIGIYSCLFHAFPNGPWEKKIKVVWS 128
Cdd:cd05889  80 RNASEDDVGYYSCSLYTYPQGSWEKVIQVVQS 111
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 19-126 1.85e-26

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 100.98  E-value: 1.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  19 EETLWDTTVR--LSETMTLECVY--PLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSL 94
Cdd:cd05718   1 QRVQVPTEVTgfLGGSVTLPCSLtsPGTTKITQVTWMKIGAGSSQNVAVFHPQYGPSVPNPYAERVEFLAARLGLRNATL 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 85540456  95 SFYNASEADIGIYSCLFHAFPNGPWEKKIKVV 126
Cdd:cd05718  81 RIRNLRVEDEGNYICEFATFPQGNRQGTTWLR 112
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 24-118 3.14e-12

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 62.36  E-value: 3.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  24 DTTVRLSETMTLECVYPLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNStvGFRNMSLSFYNASEAD 103
Cdd:cd05846   7 DTRAVLGGNATLSCNLTLPEEVLQVTWQKIKASSPENIVTYSKKYGVKIQPSYVRRISFTSS--GLNSTSITIWNVTLED 84

                        90
                ....*....|....*
gi 85540456 104 IGIYSCLFHAFPNGP 118
Cdd:cd05846  85 EGCYKCLFNTFPDGI 99
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 26-125 1.71e-10

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 57.64  E-value: 1.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  26 TVRLSETMTLECVYPLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVgfRNMSLSFYNASEADIG 105
Cdd:cd05887  10 TAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGISIQGEYQGRVSFKNYSL--NDATITLHNVGFSDSG 87

                        90       100
                ....*....|....*....|
gi 85540456 106 IYSCLFHAFPNGPWEKKIKV 125
Cdd:cd05887  88 KYICKAVTFPLGNAQSSTTV 107
IgV_1_Nectin-1_like cd05886
First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here ...
 45-123 2.99e-08

First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1 (PVRL1) or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. In addition nectins heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls), nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.


Pssm-ID: 409469  Cd Length: 113  Bit Score: 51.12  E-value: 2.99e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85540456  45 LTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTvgFRNMSLSFYNASEADIGIYSCLFHAFPNGPWEKKI 123
Cdd:cd05886  32 ITQVTWQKSTNGSKQNVAIYNPSMGVSVLPPYRERVTFLNPS--FTDGTIRLSRLELEDEGVYICEFATFPTGNRESQL 108
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 22-117 2.82e-07

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 48.34  E-value: 2.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  22 LWDTTVRLSETMTLECVY----PLTHnLTQVEWTKNTGTKTVsiAVYNPNHNMHIESNylHRVHFLNSTVG--FRNMSLS 95
Cdd:cd20989   6 PPEVRGFLGGSVTLPCHLlppnMVTH-VSQVTWQRHDEHGSV--AVFHPKQGPSFPES--ERLSFVAARLGaeLRNASLA 80

                        90       100
                ....*....|....*....|..
gi 85540456  96 FYNASEADIGIYSCLFHAFPNG 117
Cdd:cd20989  81 MFGLRVEDEGNYTCEFATFPQG 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-125 2.01e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456    25 TTVRLSETMTLECVYPLTHNL--TQVEWTKNTGTK--TVSIAVYNPNHNMHIESNylhRVHfLNSTVGFRNMSLSFYNAS 100
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEasTSVYWYRQPPGKgpTFLIAYYSNGSEEGVKKG---RFS-GRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*
gi 85540456   101 EADIGIYSCLFHAFPNGPWEKKIKV 125
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVFGKGTRL 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 137-225 3.78e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.14  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456   137 SDSYLSAEPGQDVTLTCQLPRTW--PVQQVIWEKVQP---HQVDILASCNLSQETRYTSKYlrqtRSNCSQGSMKSILII 211
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRF----SGRGDPSNGDGSLTI 77

                          90
                  ....*....|....
gi 85540456   212 PNAMAADSGLYRCR 225
Cdd:pfam07686  78 QNLTLSDSGTYTCA 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 139-237 3.77e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456    139 SYLSAEPGQDVTLTCQLPRTwPVQQVIWEKVQPHQvdilascnLSQETRYTSkylrqtrsncSQGSMKSILIIPNAMAAD 218
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGS-PPPEVTWYKQGGKL--------LAESGRFSV----------SRSGSTSTLTISNVTPED 62

                           90
                   ....*....|....*....
gi 85540456    219 SGLYRCRSEAITGKNKSFV 237
Cdd:smart00410  63 SGTYTCAATNSSGSASSGT 81
IgI_3_Contactin cd04968
Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) ...
 130-234 1.59e-04

Third immunoglobulin (Ig) domain of contactin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409357 [Multi-domain]  Cd Length: 88  Bit Score: 39.84  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456 130 SFEIAAPSDSYlsAEPGQDVTLTCqLPRTWPVQQVIWEKVQPHQVdilascnlSQETRYTSKylrqtrsncsqgsmkSIL 209
Cdd:cd04968   2 SIKVRFPADTY--ALKGQTVTLEC-FALGNPVPQIKWRKVDGSPS--------SQWEITTSE---------------PVL 55

                        90       100
                ....*....|....*....|....*
gi 85540456 210 IIPNAMAADSGLYRCRSEAITGKNK 234
Cdd:cd04968  56 EIPNVQFEDEGTYECEAENSRGKDT 80
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 139-224 2.52e-04

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 40.02  E-value: 2.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456 139 SYLSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHQVDILASCNLSQETRYTSKYLRqtRSNCSQ-GSMKSILIIPNAMAA 217
Cdd:cd05846   6 GDTRAVLGGNATLSCNLTLPEEVLQVTWQKIKASSPENIVTYSKKYGVKIQPSYVR--RISFTSsGLNSTSITIWNVTLE 83


                ....*..
gi 85540456 218 DSGLYRC 224
Cdd:cd05846  84 DEGCYKC 90
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 137-224 3.63e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 39.62  E-value: 3.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456 137 SDSYLSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHQ--------VDILASCNLSQETRYTSKylrqtrsncSQGSMKSI 208
Cdd:cd00099   4 SPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQgpefliylSSSKGKTKGGVPGRFSGS---------RDGTSSFS 74

                        90
                ....*....|....*.
gi 85540456 209 LIIPNAMAADSGLYRC 224
Cdd:cd00099  75 LTISNLQPEDSGTYYC 90
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 141-224 6.71e-04

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 38.53  E-value: 6.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456 141 LSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHqvdilaSCNLSQETRYTSKYLRQT-RSNCSQGSMKSILIipNAMAADS 219
Cdd:cd05716   7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWGSE------GCQTLVSSEGVVPGGRISlTDDPDNGVFTVTLN--QLRKEDA 78


                ....*
gi 85540456 220 GLYRC 224
Cdd:cd05716  79 GWYWC 83
IgV_1_Nectin-4_like cd05888
First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are ...
 26-127 6.94e-04

First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4 or LNIR receptor). Nectin-4 belongs to the nectin family, which is comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example nectin-4 trans-interacts with nectin-1. Nectin-4 has also been shown to interact with the actin filament-binding protein, afadin. Unlike the other nectins, which are widely expressed in adult tissues, nectin-4 is mainly expressed during embryogenesis, and is not detected in normal adult tissue or in serum. Nectin-4 is re-expressed in breast carcinoma, and patients having metastatic breast cancer have a circulating form of nectin-4 formed from the ectodomain


Pssm-ID: 409471  Cd Length: 108  Bit Score: 38.73  E-value: 6.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456  26 TVRLSETMTLECVYPLTHNLT--QVEWTK-NTGTKTVSIAVYNPNHNMHIESNYLHRVHFlNSTVGFRNMSLSFYNASEA 102
Cdd:cd05888   4 TVVLGQDAKLPCFYRGDSGEQvgQVAWARvDAGEGAQEIALLHSKYGLHVFPAYEGRVEQ-PPPPRPADGSVLLRNAVQA 82

                        90       100
                ....*....|....*....|....*.
gi 85540456 103 DIGIYSCLFHAFPNGPWEKKIKV-VW 127
Cdd:cd05888  83 DEGEYECRVSTFPAGNFQAELRLrVL 108
IgI_2_Robo cd05724
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 146-242 1.46e-03

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409389 [Multi-domain]  Cd Length: 87  Bit Score: 37.00  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456 146 GQDVTLTCQLPRTWPVQQVIWEKV-QPhqvdilasCNLSQETRYTskylrqtrsnCSQGSmksiLIIPNAMAADSGLYRC 224
Cdd:cd05724  12 GEMAVLECSPPRGHPEPTVSWRKDgQP--------LNLDNERVRI----------VDDGN----LLIAEARKSDEGTYKC 69

                        90
                ....*....|....*...
gi 85540456 225 RSEAITGKNKSFVIRLII 242
Cdd:cd05724  70 VATNMVGERESRAARLSV 87
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 142-225 8.57e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.85  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85540456   142 SAEPGQDVTLTCQLpRTWPVQQVIWEKVQPHQVDilascnlsqetrytskylrQTRSNCSQGSMKSILIIPNAMAADSGL 221
Cdd:pfam13927  12 TVREGETVTLTCEA-TGSPPPTITWYKNGEPISS-------------------GSTRSRSLSGSNSTLTISNVTRSDAGT 71


                  ....
gi 85540456   222 YRCR 225
Cdd:pfam13927  72 YTCV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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