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    Abca8 ATP binding cassette subfamily A member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303637, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abca8provided by RGD
    Official Full Name
    ATP binding cassette subfamily A member 8provided by RGD
    Primary source
    RGD:1307069
    See related
    EnsemblRapid:ENSRNOG00000004040 AllianceGenome:RGD:1307069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abca8b
    Summary
    Predicted to enable ABC-type xenobiotic transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; positive regulation of cholesterol efflux; and sphingomyelin biosynthetic process. Predicted to be located in basolateral plasma membrane and endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human ABCA8 (ATP binding cassette subfamily A member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 93.7), Lung (RPKM 38.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abca8 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95416984..95490647, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94917520..94991199, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98236919..98308288, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012B07 gene like Neighboring gene ribosomal protein L23a, pseudogene 1 Neighboring gene ATP-binding cassette, subfamily A (ABC1), member 8a Neighboring gene ATP binding cassette subfamily A member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of ABCA8, a new drug transporter. Tsuruoka S, et al. Biochem Biophys Res Commun, 2002 Oct 18. PMID 12379217
    2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingomyelin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ABC-type organic anion transporter ABCA8; ATP binding cassette subfamily A member 8
    Names
    ATP-binding cassette sub-family A member 8-B
    ATP-binding cassette, sub-family A (ABC1), member 8
    ATP-binding cassette, sub-family A (ABC1), member 8b
    ATP-binding cassette, subfamily A (ABC1), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430208.1 → NP_001417137.1  ATP binding cassette subfamily A member 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A3F8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      95416984..95490647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087437.2 → XP_038943365.1  ABC-type organic anion transporter ABCA8 isoform X1

      Related
      ENSRNOP00000099543.1, ENSRNOT00000162872.1
      Conserved Domains (1) summary
      TIGR01257
      Location:261 → 1597
      rim_protein; retinal-specific rim ABC transporter

    2. XM_039087438.1 → XP_038943366.1  ABC-type organic anion transporter ABCA8 isoform X2

      UniProtKB/TrEMBL
      D3ZAE9
      Related
      ENSRNOP00000005489.9, ENSRNOT00000005489.10
      Conserved Domains (1) summary
      TIGR01257
      Location:227 → 1563
      rim_protein; retinal-specific rim ABC transporter
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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