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    Map4 microtubule-associated protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367171, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Map4provided by RGD
    Official Full Name
    microtubule-associated protein 4provided by RGD
    Primary source
    RGD:1564359
    See related
    EnsemblRapid:ENSRNOG00000020748 AllianceGenome:RGD:1564359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mtap4
    Summary
    Predicted to enable microtubule binding activity and microtubule stabilizing activity. Predicted to be involved in microtubule polymerization; negative regulation of non-motile cilium assembly; and plasma membrane bounded cell projection organization. Predicted to act upstream of or within cell division; microtubule cytoskeleton organization; and microtubule sliding. Located in axon. Orthologous to human MAP4 (microtubule associated protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 577.6), Heart (RPKM 378.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map4 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118800393..118942805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109925233..110064370)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118013584..118159934)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cathelicidin antimicrobial peptide Neighboring gene cell division cycle 25A Neighboring gene DExH-box helicase 30 Neighboring gene uncharacterized LOC134480238 Neighboring gene small nucleolar RNA SNORA43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes. Hu J, et al. Cell Death Dis, 2014 Sep 18. PMID 25232678, Free PMC Article
    2. MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1. Fang YD, et al. PLoS One, 2011. PMID 22164227, Free PMC Article
    3. MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Samora CP, et al. Nat Cell Biol, 2011 Aug 7. PMID 21822276
    4. Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. Ghossoub R, et al. J Cell Sci, 2013 Jun 15. PMID 23572511, Free PMC Article
    5. Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. Ebneth A, et al. Cell Motil Cytoskeleton, 1999 Nov. PMID 10542369

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When targeted to mitochondria, MAP4 was found to lead to mPTP opening and induce apoptosis.
      Title: Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes.
    2. there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization
      Title: MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule stabilizing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule sliding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein 4
    Names
    MAP-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024278.2 → NP_001019449.1  microtubule-associated protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001019449.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5M7W5, Q75NR5, Q75NR6
      UniProtKB/TrEMBL
      A0A8I6AEN3
      Related
      ENSRNOP00000095245.2, ENSRNOT00000098378.2

    2. NM_001419953.1 → NP_001406882.1  microtubule-associated protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      Related
      ENSRNOP00000053011.6, ENSRNOT00000056166.6

    3. NM_001419954.1 → NP_001406883.1  microtubule-associated protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2QPR2, A6I3D0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118800393..118942805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243813.5 → XP_006243875.1  microtubule-associated protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (1) summary
      pfam00418
      Location:2042 → 2071
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    2. XM_006243815.5 → XP_006243877.1  microtubule-associated protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (1) summary
      pfam00418
      Location:2042 → 2071
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    3. XM_006243814.5 → XP_006243876.1  microtubule-associated protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (1) summary
      pfam00418
      Location:2042 → 2071
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    4. XM_006243816.5 → XP_006243878.1  microtubule-associated protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JW88, A0A8I6ART8
      Related
      ENSRNOP00000096077.1, ENSRNOT00000110699.2
      Conserved Domains (1) summary
      pfam00418
      Location:2042 → 2071
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    5. XM_017595795.3 → XP_017451284.1  microtubule-associated protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ART8

    6. XM_006243818.5 → XP_006243880.1  microtubule-associated protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (1) summary
      pfam00418
      Location:2004 → 2033
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    7. XM_063265908.1 → XP_063121978.1  microtubule-associated protein 4 isoform X7

    8. XM_039082631.2 → XP_038938559.1  microtubule-associated protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (3) summary
      PHA03247
      Location:1686 → 1980
      PHA03247; large tegument protein UL36; Provisional
      TIGR03835
      Location:12 → 440
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam00418
      Location:2004 → 2034
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    9. XM_063265909.1 → XP_063121979.1  microtubule-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZTS3
      Related
      ENSRNOP00000081853.2, ENSRNOT00000099144.2

    10. XM_006243819.5 → XP_006243881.1  microtubule-associated protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (1) summary
      pfam00418
      Location:2004 → 2033
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    11. XM_063265910.1 → XP_063121980.1  microtubule-associated protein 4 isoform X12

    12. XM_039082632.2 → XP_038938560.1  microtubule-associated protein 4 isoform X11

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (2) summary
      PHA03247
      Location:1686 → 1980
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:2004 → 2034
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    13. XM_063265911.1 → XP_063121981.1  microtubule-associated protein 4 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZSY4
      Related
      ENSRNOP00000080376.2, ENSRNOT00000105433.2

    14. XM_006243820.5 → XP_006243882.1  microtubule-associated protein 4 isoform X14

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (1) summary
      pfam00418
      Location:1968 → 1997
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    15. XM_039082633.2 → XP_038938561.1  microtubule-associated protein 4 isoform X15

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (3) summary
      PHA03247
      Location:1687 → 1964
      PHA03247; large tegument protein UL36; Provisional
      TIGR03835
      Location:12 → 440
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam00418
      Location:1968 → 1998
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    16. XM_063265912.1 → XP_063121982.1  microtubule-associated protein 4 isoform X16

    17. XM_039082634.2 → XP_038938562.1  microtubule-associated protein 4 isoform X17

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (3) summary
      TIGR03835
      Location:12 → 440
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam05109
      Location:1743 → 2031
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:1930 → 1960
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    18. XM_063265914.1 → XP_063121984.1  microtubule-associated protein 4 isoform X19

    19. XM_039082635.2 → XP_038938563.1  microtubule-associated protein 4 isoform X18

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (3) summary
      PHA03247
      Location:1686 → 1894
      PHA03247; large tegument protein UL36; Provisional
      TIGR03835
      Location:12 → 440
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam00418
      Location:1930 → 1960
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    20. XM_063265915.1 → XP_063121985.1  microtubule-associated protein 4 isoform X20

    21. XM_039082636.2 → XP_038938564.1  microtubule-associated protein 4 isoform X21

      UniProtKB/TrEMBL
      A0A8I6ART8
      Conserved Domains (3) summary
      PHA03247
      Location:1686 → 1894
      PHA03247; large tegument protein UL36; Provisional
      TIGR03835
      Location:12 → 440
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam00418
      Location:1930 → 1960
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    22. XM_006243821.5 → XP_006243883.1  microtubule-associated protein 4 isoform X22

      UniProtKB/TrEMBL
      A0A8I6AKJ8
      Related
      ENSRNOP00000095817.2, ENSRNOT00000109752.2
      Conserved Domains (1) summary
      pfam00418
      Location:966 → 995
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    23. XM_063265916.1 → XP_063121986.1  microtubule-associated protein 4 isoform X23

    24. XM_006243823.5 → XP_006243885.1  microtubule-associated protein 4 isoform X24

      UniProtKB/TrEMBL
      A0A8I6AEN3
      Conserved Domains (1) summary
      pfam00418
      Location:928 → 957
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    25. XM_063265917.1 → XP_063121987.1  microtubule-associated protein 4 isoform X25

    26. XM_063265918.1 → XP_063121988.1  microtubule-associated protein 4 isoform X26

    27. XM_063265920.1 → XP_063121990.1  microtubule-associated protein 4 isoform X27

    28. XM_039082639.2 → XP_038938567.1  microtubule-associated protein 4 isoform X28

      UniProtKB/TrEMBL
      A0A8I6AKJ8
      Conserved Domains (2) summary
      PHA03307
      Location:547 → 892
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:892 → 922
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    29. XM_063265921.1 → XP_063121991.1  microtubule-associated protein 4 isoform X29

      Related
      ENSRNOP00000069786.2, ENSRNOT00000056161.6

    30. XM_063265922.1 → XP_063121992.1  microtubule-associated protein 4 isoform X30

    31. XM_063265923.1 → XP_063121993.1  microtubule-associated protein 4 isoform X31

    32. XM_063265935.1 → XP_063122005.1  microtubule-associated protein 4 isoform X46

    33. XM_063265937.1 → XP_063122007.1  microtubule-associated protein 4 isoform X47

    34. XM_063265932.1 → XP_063122002.1  microtubule-associated protein 4 isoform X43

    35. XM_039082641.2 → XP_038938569.1  microtubule-associated protein 4 isoform X39

      Conserved Domains (2) summary
      PHA03247
      Location:478 → 740
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:744 → 774
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    36. XM_063265930.1 → XP_063122000.1  microtubule-associated protein 4 isoform X41

    37. XM_063265933.1 → XP_063122003.1  microtubule-associated protein 4 isoform X44

    38. XM_063265934.1 → XP_063122004.1  microtubule-associated protein 4 isoform X45

    39. XM_063265929.1 → XP_063121999.1  microtubule-associated protein 4 isoform X40

      Related
      ENSRNOP00000081325.2, ENSRNOT00000117109.2

    40. XM_063265931.1 → XP_063122001.1  microtubule-associated protein 4 isoform X42

      UniProtKB/TrEMBL
      A0A8I5ZRQ1

    41. XM_039082640.2 → XP_038938568.1  microtubule-associated protein 4 isoform X32

      Conserved Domains (2) summary
      PHA03247
      Location:508 → 756
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:818 → 848
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    42. XM_017595797.3 → XP_017451286.1  microtubule-associated protein 4 isoform X37

    43. XM_017595796.3 → XP_017451285.1  microtubule-associated protein 4 isoform X35

    44. XM_063265928.1 → XP_063121998.1  microtubule-associated protein 4 isoform X38

    45. XM_063265926.1 → XP_063121996.1  microtubule-associated protein 4 isoform X36

      UniProtKB/TrEMBL
      A0A8I6AL32

    46. XM_063265924.1 → XP_063121994.1  microtubule-associated protein 4 isoform X33

    47. XM_063265925.1 → XP_063121995.1  microtubule-associated protein 4 isoform X34

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M7W5.1 GenPept UniProtKB/Swiss-Prot:Q5M7W5

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