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Conserved domains on  [gi|1958799733|ref|XP_038938567|]
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microtubule-associated protein 4 isoform X28 [Rattus norvegicus]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 892-921 6.93e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 66.28  E-value: 6.93e-14
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799733  892 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 921
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 923-952 1.12e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.12e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799733  923 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 952
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 954-984 2.44e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799733  954 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 984
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 831-852 1.53e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 1.53e-07
                           10        20
                   ....*....|....*....|..
gi 1958799733  831 DLKSVRSKVGSTENMKHQPGGG 852
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 547-892 6.84e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 6.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  547 PPSDPALPLETKVAtvqikdketvqtqeELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKStlPVDEGSPLEKLEQK 626
Cdd:PHA03307   119 PTPPPASPPPSPAP--------------DLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAAS--SRQAALPLSSPEET 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  627 ETSGSQPPElCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSS------APALRPG 700
Cdd:PHA03307   183 ARAPSSPPA-EPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpeneCPLPRPA 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  701 PKTTPTISKATSPSTLVSTGSSSRSPSTTlPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSvkrnTTPTGAtP 780
Cdd:PHA03307   262 PITLPTRIWEASGWNGPSSRPGPASSSSS-PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSE-S 335

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  781 PAGMASTRvkpmSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPD----LKSVRSKVGSTENMKH----QPGGG 852
Cdd:PHA03307   336 SRGAAVSP----GPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAgrptRRRARAAVAGRARRRDatgrFPAGR 411

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1958799733  853 RAKVEKKTEAATTAGNPEPNAVTKAASSISSAPKPPAGKV 892
Cdd:PHA03307   412 PRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPPGRV 451
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 892-921 6.93e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 66.28  E-value: 6.93e-14
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799733  892 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 921
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 923-952 1.12e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.12e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799733  923 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 952
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 954-984 2.44e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799733  954 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 984
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 831-852 1.53e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 1.53e-07
                           10        20
                   ....*....|....*....|..
gi 1958799733  831 DLKSVRSKVGSTENMKHQPGGG 852
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 547-892 6.84e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 6.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  547 PPSDPALPLETKVAtvqikdketvqtqeELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKStlPVDEGSPLEKLEQK 626
Cdd:PHA03307   119 PTPPPASPPPSPAP--------------DLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAAS--SRQAALPLSSPEET 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  627 ETSGSQPPElCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSS------APALRPG 700
Cdd:PHA03307   183 ARAPSSPPA-EPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpeneCPLPRPA 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  701 PKTTPTISKATSPSTLVSTGSSSRSPSTTlPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSvkrnTTPTGAtP 780
Cdd:PHA03307   262 PITLPTRIWEASGWNGPSSRPGPASSSSS-PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSE-S 335

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  781 PAGMASTRvkpmSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPD----LKSVRSKVGSTENMKH----QPGGG 852
Cdd:PHA03307   336 SRGAAVSP----GPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAgrptRRRARAAVAGRARRRDatgrFPAGR 411

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1958799733  853 RAKVEKKTEAATTAGNPEPNAVTKAASSISSAPKPPAGKV 892
Cdd:PHA03307   412 PRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPPGRV 451
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 547-887 4.27e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 4.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  547 PPSDPALPLETKVATVQIKDKETVQTQEELSEDSQLESVQLEGQSAVPPctiSPEPvKAADQKSTLPvDEGSPLEKLEQK 626
Cdd:pfam05109  442 PNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTP---SPSP-RDNGTESKAP-DMTSPTSAVTTP 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  627 ETSGSQP-PELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSSAPALRPGPKTTP 705
Cdd:pfam05109  517 TPNATSPtPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVG 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  706 TISKATSPSTLVSTGSSSRSPSTTLPKRPTTTKTEGK----PADVKRMTAKSATADLSRSKTTSASSVKRNTTPTGATPP 781
Cdd:pfam05109  597 ETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPT 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  782 AGMASTRVKPMSA-------------PCRSSVALSVDKKPTSTKP------------SSSAPRVSRLATTvSAPDLKSVR 836
Cdd:pfam05109  677 GGENITQVTPASTsthhvstsspaprPGTTSQASGPGNSSTSTKPgevnvtkgtppkNATSPQAPSGQKT-AVPTVTSTG 755

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958799733  837 SKVGSTENMKHQPG-GGRAKVEKKTEAATTAGNPEP--NAVTKAASSISSAPKP 887
Cdd:pfam05109  756 GKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTryNATTYLPPSTSSKLRP 809
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 892-921 6.93e-14

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 66.28  E-value: 6.93e-14
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799733  892 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 921
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 923-952 1.12e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.12e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799733  923 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 952
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 954-984 2.44e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799733  954 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 984
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 831-852 1.53e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 1.53e-07
                           10        20
                   ....*....|....*....|..
gi 1958799733  831 DLKSVRSKVGSTENMKHQPGGG 852
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 547-892 6.84e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 6.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  547 PPSDPALPLETKVAtvqikdketvqtqeELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKStlPVDEGSPLEKLEQK 626
Cdd:PHA03307   119 PTPPPASPPPSPAP--------------DLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAAS--SRQAALPLSSPEET 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  627 ETSGSQPPElCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSS------APALRPG 700
Cdd:PHA03307   183 ARAPSSPPA-EPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpeneCPLPRPA 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  701 PKTTPTISKATSPSTLVSTGSSSRSPSTTlPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSvkrnTTPTGAtP 780
Cdd:PHA03307   262 PITLPTRIWEASGWNGPSSRPGPASSSSS-PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSE-S 335

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  781 PAGMASTRvkpmSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPD----LKSVRSKVGSTENMKH----QPGGG 852
Cdd:PHA03307   336 SRGAAVSP----GPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAgrptRRRARAAVAGRARRRDatgrFPAGR 411

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1958799733  853 RAKVEKKTEAATTAGNPEPNAVTKAASSISSAPKPPAGKV 892
Cdd:PHA03307   412 PRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPPGRV 451
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-888 4.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  547 PPSDPA---LPLETKVATVQIKDKETVQTQEELSEDSqlesvqlegqSAVPPCTISPEPVKAA-DQKSTLPVDEGSPLE- 621
Cdd:PHA03247  2511 APSRLApaiLPDEPVGEPVHPRMLTWIRGLEELASDD----------AGDPPPPLPPAAPPAApDRSVPPPRPAPRPSEp 2580

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  622 KLEQKETSGSQPPElcsgvsrQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSSAPAlRPGP 701
Cdd:PHA03247  2581 AVTSRARRPDAPPQ-------SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP-PERP 2652

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  702 KTTPTISKATSPS-TLVSTGSSSRSPSTTLPKRPTTTKTEG------KPADVKRMTAKSATADLSRSKTTSASSVKRNTT 774
Cdd:PHA03247  2653 RDDPAPGRVSRPRrARRLGRAAQASSPPQRPRRRAARPTVGsltslaDPPPPPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  775 PT-----GATPPAGMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENMKHQP 849
Cdd:PHA03247  2733 PAlpaapAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1958799733  850 GGGRAkveKKTEAATTAGNPEPNAVTKAASSISSAPKPP 888
Cdd:PHA03247  2813 APAAA---LPPAASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
PHA03247 PHA03247
large tegument protein UL36; Provisional
 594-830 1.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  594 PPCTISPEPvkaadqkSTLPVDEGSPLEKLEQkETSGSQPPELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKA 673
Cdd:PHA03247  2702 PPPPPTPEP-------APHALVSATPLPPGPA-AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  674 KPIT-------------ETKVAEKRTSPSKPSSAPALRPGPktTPTISKATSPSTLVSTGSSSRSPSTTLPKRP--TTTK 738
Cdd:PHA03247  2774 APAAgpprrltrpavasLSESRESLPSPWDPADPPAAVLAP--AAALPPAASPAGPLPPPTSAQPTAPPPPPGPppPSLP 2851

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  739 TEGKPA---DVKRM------TAKSATADLSRSKTTSASSVKRNTTPTgATPPAGMASTRVKPMSAPCRSSVALSVDKKPT 809
Cdd:PHA03247  2852 LGGSVApggDVRRRppsrspAAKPAAPARPPVRRLARPAVSRSTESF-ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          250       260
                   ....*....|....*....|.
gi 1958799733  810 STKPSSSAPRVSRLATTVSAP 830
Cdd:PHA03247  2931 PPPPPPPRPQPPLAPTTDPAG 2951
PHA03247 PHA03247
large tegument protein UL36; Provisional
 591-889 3.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  591 SAVPPCTISPEPVKAADQKSTLPVDEGSPLEKLEQKETSGSQPPelcSGVSRQEEGKAAVGLTGNdiATPPNKELPPSPE 670
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP---GRVSRPRRARRLGRAAQA--SSPPQRPRRRAAR 2689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  671 KKAKPITetkvAEKRTSPSKPSSAPALRPGPKTTPTISKATSPSTLVSTGSSSRSPsttlPKRPTTTKTEGKPADVKRMT 750
Cdd:PHA03247  2690 PTVGSLT----SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP----PAVPAGPATPGGPARPARPP 2761

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  751 AKSATADLSRSKTTSASSVKRNTTPTGATPPAGMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSAPRVSrlATTVSAP 830
Cdd:PHA03247  2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT--SAQPTAP 2839

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  831 DLKSVRSKVGSTENMKHQPGGG-RAKVEKKTEAATTAGNPEPNAVTKAASSISSAPKPPA 889
Cdd:PHA03247  2840 PPPPGPPPPSLPLGGSVAPGGDvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 547-887 4.27e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 4.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  547 PPSDPALPLETKVATVQIKDKETVQTQEELSEDSQLESVQLEGQSAVPPctiSPEPvKAADQKSTLPvDEGSPLEKLEQK 626
Cdd:pfam05109  442 PNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTP---SPSP-RDNGTESKAP-DMTSPTSAVTTP 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  627 ETSGSQP-PELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSSAPALRPGPKTTP 705
Cdd:pfam05109  517 TPNATSPtPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVG 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  706 TISKATSPSTLVSTGSSSRSPSTTLPKRPTTTKTEGK----PADVKRMTAKSATADLSRSKTTSASSVKRNTTPTGATPP 781
Cdd:pfam05109  597 ETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPT 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  782 AGMASTRVKPMSA-------------PCRSSVALSVDKKPTSTKP------------SSSAPRVSRLATTvSAPDLKSVR 836
Cdd:pfam05109  677 GGENITQVTPASTsthhvstsspaprPGTTSQASGPGNSSTSTKPgevnvtkgtppkNATSPQAPSGQKT-AVPTVTSTG 755

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958799733  837 SKVGSTENMKHQPG-GGRAKVEKKTEAATTAGNPEP--NAVTKAASSISSAPKP 887
Cdd:pfam05109  756 GKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTryNATTYLPPSTSSKLRP 809
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 565-888 4.97e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  565 KDKETVQTQEELSEDSQLESVQLEGQSAVPPctispepvKAADQKSTLPVDEGSPLEKLEQKEtsGSQPPELCSGVSRQE 644
Cdd:PTZ00449   491 KSKKKLAPIEEEDSDKHDEPPEGPEASGLPP--------KAPGDKEGEEGEHEDSKESDEPKE--GGKPGETKEGEVGKK 560

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  645 EGKAavglTGNDIATPPNKELPPSPEKKAKPITETKVAEKRTSPSKPSSaPALRPGPKtTPTISK----------ATSPS 714
Cdd:PTZ00449   561 PGPA----KEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQR-PTRPKSPK-LPELLDipkspkrpesPKSPK 634

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  715 TLVSTGSSSRSPSTTLPKRPTTTKTEGKPA-----DVKRMTAKSATADLSRSKTT--------SASSVKRNTTPTgaTPP 781
Cdd:PTZ00449   635 RPPPPQRPSSPERPEGPKIIKSPKPPKSPKppfdpKFKEKFYDDYLDAAAKSKETkttvvldeSFESILKETLPE--TPG 712

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799733  782 AGMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSaprvsrlaTTVSAPDLKSVRSKvgstENMKHQPGGGRAKVEKKTE 861
Cdd:PTZ00449   713 TPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDI--------EFFTPPEEERTFFH----ETPADTPLPDILAEEFKEE 780

                          330       340
                   ....*....|....*....|....*..
gi 1958799733  862 AATTAGNPEPNAVTKAASSISSAPKPP 888
Cdd:PTZ00449   781 DIHAETGEPDEAMKRPDSPSEHEDKPP 807
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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